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公开(公告)号：US07438910B2
公开(公告)日：2008-10-21
申请号：US10656769
申请日：2003-09-05
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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公开(公告)号：US08236559B2
公开(公告)日：2012-08-07
申请号：US12210313
申请日：2008-09-15
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
IPC分类号： C12N5/16
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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公开(公告)号：US08518407B2
公开(公告)日：2013-08-27
申请号：US13450126
申请日：2012-04-18
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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公开(公告)号：US20120269824A1
公开(公告)日：2012-10-25
申请号：US13450126
申请日：2012-04-18
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
IPC分类号： A61K39/395 , A61P19/02 , A61P29/00 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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公开(公告)号：US20090214559A1
公开(公告)日：2009-08-27
申请号：US12210313
申请日：2008-09-15
申请人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
发明人： Brian Varnum , Chris Vezina , Alison Witte , Xueming Qian , Francis Hall Martin , Haichun Huang , Gary Elliott
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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公开(公告)号：US08609816B2
公开(公告)日：2013-12-17
申请号：US12092866
申请日：2006-12-08
申请人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合O8E的人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症的方法。
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公开(公告)号：US20090074660A1
公开(公告)日：2009-03-19
申请号：US12092866
申请日：2006-12-08
申请人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
IPC分类号： A61K51/10 , C07K16/00 , C07H21/00 , C12N5/00 , A61P35/00 , C12P21/00 , C12N15/63 , A61K39/395
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合O8E的人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了治疗癌症的方法。
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公开(公告)号：US08399647B2
公开(公告)日：2013-03-19
申请号：US13237502
申请日：2011-09-20
申请人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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公开(公告)号：US08367063B2
公开(公告)日：2013-02-05
申请号：US12782376
申请日：2010-05-18
申请人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
IPC分类号： A61K39/395 , A61K39/00 , C07K16/24 , C07K16/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
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公开(公告)号：US20120093826A1
公开(公告)日：2012-04-19
申请号：US13254752
申请日：2010-03-05
申请人： Jonathan Alexander Terrett , Heidi Leblanc , Haichun Huang , Erika Meaddough , Chin Pan , Bingliang Chen , Chetana Rao-Naik
发明人： Jonathan Alexander Terrett , Heidi Leblanc , Haichun Huang , Erika Meaddough , Chin Pan , Bingliang Chen , Chetana Rao-Naik
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , A61P35/02 , C12P21/08 , C12N5/16 , A61P35/00 , C07K16/28 , C12N5/10
CPC分类号： C07K16/3007 , A61K33/24 , A61K39/39558 , A61K2039/505 , C07K16/3023 , C07K2317/24 , C07K2317/41 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.
摘要翻译： 本公开内容提供分离的单克隆抗体，特别是人单克隆抗体，更特别是工程化的抗体，其导致与Fc受体的增加的结合和/或增加对具有高亲和力特异性结合CADM1的ADCC或免疫偶联物的效力。 还提供编码CADM1抗体的核酸分子，表达载体，宿主细胞和用于表达CADM1抗体的方法。 还提供了包含CADM1抗体的双特异性分子和药物组合物。 公开了用于检测CADM1的方法，以及用于治疗各种癌症的方法，包括肺癌和胰腺癌。
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