公开(公告)号：US20130338479A1

公开(公告)日：2013-12-19

申请号：US13140748

申请日：2009-12-18

申请人： Brian William Pogue ,  Venkataramanan Krishnaswamy ,  Keith D. Paulsen ,  Pilar Beatriz Garcia Allende ,  Olga Maria Conde ,  José Miguel Lopez-Higuera

发明人： Brian William Pogue ,  Venkataramanan Krishnaswamy ,  Keith D. Paulsen ,  Pilar Beatriz Garcia Allende ,  Olga Maria Conde ,  José Miguel Lopez-Higuera

IPC分类号： A61B5/00 ,  A61B5/145

CPC分类号： A61B5/0068 ,  A61B5/0059 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/14546 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/742 ,  A61B2576/00 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/06 ,  G01J3/10 ,  G01J3/2823 ,  G01N21/4795 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0618 ,  G01N2201/1296 ,  G06F19/3481 ,  G16H40/63

摘要： A method and apparatus is described for optically scanning a field of view, the field of view including at least part of an organ as exposed during surgery, and for identifying and classifying areas of tumor within the field of view. The apparatus obtains a spectrum at each pixel of the field of view, and classifies pixels with a kNN-type or neural network classifier previously trained on samples of tumor and organ classified by a pathologist. Embodiments use statistical parameters extracted from each pixel and neighboring pixels. Results are displayed as a color-encoded map of tissue types to the surgeon. In variations, the apparatus provides light at one or more fluorescence stimulus wavelengths and measures the fluorescence light spectrum emitted from tissue corresponding to each stimulus wavelength. The measured emitted fluorescence light spectra are further used by the classifier to identify tissue types in the field of view.

摘要翻译： 描述了用于光学扫描视野的方法和装置，视野包括在外科手术期间暴露的器官的至少一部分，以及用于识别和分类视野内的肿瘤区域。 该装置在视场的每个像素处获得光谱，并且使用先前已经由病理学家分类的肿瘤和器官样本训练的kNN型或神经网络分类器对像素进行分类。 实施例使用从每个像素和相邻像素提取的统计参数。 结果显示为外科医生的组织类型的颜色编码图。 在变型中，该装置在一个或多个荧光刺激波长处提供光，并测量从对应于每个刺激波长的组织发射的荧光光谱。 测量的发射荧光光谱被分类器进一步用于鉴定视野中的组织类型。