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    Nucleotide sequences which code for the msiK gene
    2.
    发明授权
    Nucleotide sequences which code for the msiK gene 有权
    编码msiK基因的核苷酸序列

    公开(公告)号：US07252977B2

    公开(公告)日：2007-08-07

    申请号：US09962618

    申请日：2001-09-26

    申请人： Brigitte Bathe ,  Natalie Schischka ,  Mike Farwick ,  Walter Pfefferle

    发明人： Brigitte Bathe ,  Natalie Schischka ,  Mike Farwick ,  Walter Pfefferle

    IPC分类号： C12P13/04 ,  C12P13/10 ,  C12N15/00 ,  C12N1/20 ,  C07H21/02 ,  C07K1/00

    CPC分类号： C12P13/08 ,  C07K14/34

    摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which encodes the sugar import protein K (msiK) gene, and a host-vector system having a coryneform host bacterium in which the msiK gene is present in enhanced form and a vector which carries at least the msiK gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

    摘要翻译： 本发明涉及具有编码糖进入蛋白K（msiK）基因的多核苷酸序列的谷氨酸棒杆菌的分离的多核苷酸，以及具有其中以增强形式存在msiK基因的棒状细胞宿主细菌的宿主 - 载体系统和载体 其至少携带根据SEQ ID No 1的msiK基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

    Nucleotide sequences coding for the sigM gene
    6.
    发明授权
    Nucleotide sequences coding for the sigM gene 失效
    编码sigM基因的核苷酸序列

    公开(公告)号：US06995000B2

    公开(公告)日：2006-02-07

    申请号：US09942935

    申请日：2001-08-31

    申请人： Brigitte Bathe ,  Christine Bastuck ,  Mike Farwick ,  Thomas Hermann ,  Walter Pfefferle

    发明人： Brigitte Bathe ,  Christine Bastuck ,  Mike Farwick ,  Thomas Hermann ,  Walter Pfefferle

    IPC分类号： C12P13/04

    CPC分类号： C07K14/34 ,  C12P13/08

    摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which encodes the sigma factor M (sigM) gene, and a host-vector system having a coryneform host bacterium in which the sigM gene is present in enhanced form and a vector which carries at least the sigM gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

    摘要翻译： 本发明涉及具有编码σ因子M（sigM）基因的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中sigM基因以增强形式存在的棒状细胞宿主细菌的宿主 - 载体系统和载体， 至少携带根据SEQ ID No 1的sigM基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

    Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene
    7.
    发明授权
    Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene 有权
    使用具有减毒mqo基因的棒状细菌通过发酵生产L-氨基酸的方法

    公开(公告)号：US07049106B2

    公开(公告)日：2006-05-23

    申请号：US10118325

    申请日：2002-04-09

    申请人： Mike Farwick ,  Brigitte Bathe ,  Thomas Hermann ,  Achim Marx ,  Walter Pfefferle

    发明人： Mike Farwick ,  Brigitte Bathe ,  Thomas Hermann ,  Achim Marx ,  Walter Pfefferle

    IPC分类号： C12P13/04

    CPC分类号： C12N9/0036 ,  C12P13/08

    摘要： A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.

    摘要翻译： 其中生产L-氨基酸的方法，其中将其中编码苹果酸醌氧化还原酶的mqo基因的表达减弱的棒状细菌（例如谷氨酸棒杆菌）被发酵以产生所需的氨基酸，并且氨基酸浓缩在 培养基或细胞分离。 任选地，所需氨基酸的生物合成途径中的其它基因被增强，和/或减少氨基酸形成的代谢途径被抑制。

    Nucleotide sequences coding for the citE gene
    10.
    发明授权
    Nucleotide sequences coding for the citE gene 失效
    编码citE基因的核苷酸序列

    公开(公告)号：US07129066B2

    公开(公告)日：2006-10-31

    申请号：US10375355

    申请日：2003-02-28

    申请人： Mike Farwick ,  Klaus Huthmacher ,  Achim Marx ,  Brigitte Bathe ,  Walter Pfefferle

    发明人： Mike Farwick ,  Klaus Huthmacher ,  Achim Marx ,  Brigitte Bathe ,  Walter Pfefferle

    IPC分类号： C12P13/08 ,  C12P13/04 ,  C12N9/88 ,  C07H21/04

    CPC分类号： C12Y401/03006 ,  C12N9/88

    摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing the amino acid sequence of SEQ ID No. 2, b) polynucleotide that codes for a polypeptide containing an amino acid sequence that is at least 70% identical with the amino acid sequence of SEQ ID No. 2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b) or c), and to a process for the production of L-amino acids by fermentation using coryneform bacteria in which at least the citE gene is present in attenuated form, and to the use of polynucleotides containing the sequences of the invention as hybridization probes.

    摘要翻译： 本发明涉及含有多核苷酸序列的多核苷酸序列，该多核苷酸序列选自a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 对于含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少含有 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及通过发酵使用其中至少有citE基因以减毒形式存在的棒状细菌产生L-氨基酸的方法， 使用含有本发明序列的多核苷酸作为杂交探针。