专利检索 ap:("Bristol-Myers Squibb Company" OR "The Scripps Research Institute") AND inv:"Michael Anthony Schmidt" 第 1 页

1.

发明授权
Phosphorus (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophosphorus (V) compounds 有权

公开(公告)号：US12077558B2

公开(公告)日：2024-09-03

申请号：US18167772

申请日：2023-02-10

申请人： Bristol-Myers Squibb Company , The Scripps Research Institute

发明人： Michael Anthony Schmidt , Bin Zheng , Kyle Knouse , Justine deGruyter , Martin D. Eastgate , Phil Baran , William R. Ewing , Richard E. Olson , Ivar M. McDonald

IPC分类号： C07H21/00 , C07H19/11 , C07H19/213

CPC分类号： C07H21/00

摘要： The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

2.

发明授权
Phosphorous (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (V) compounds 有权

公开(公告)号：US11613554B2

公开(公告)日：2023-03-28

申请号：US16382692

申请日：2019-04-12

申请人： Bristol-Myers Squibb Company , The Scripps Research Institute

发明人： Michael Anthony Schmidt , Bin Zheng , Kyle Knouse , Justine deGruyter , Martin D. Eastgate , Phil Baran , William R. Ewing , Richard E. Olson , Ivar M. McDonald

IPC分类号： C07H21/00

摘要： The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

3.

发明申请
USE OF FUCOSYLATION INHIBITOR FOR PRODUCING AFUCOSYLATED ANTIBODY 有权

公开(公告)号：US20230075422A1

公开(公告)日：2023-03-09

申请号：US17787461

申请日：2020-12-18

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Ping XU , Anurag Khetan , Rodney Lawrence Parsons , Michael J. Smith , Michael Anthony Schmidt

IPC分类号： C07K16/00 , C12N5/07 , A61P35/00

摘要： The present invention provides inhibitors of fucosylation during protein expression from mammalian cells. The inhibitors are derived from rhamnose and act by inhibition of GDP-mannose 4,6-dehydratase (GMD). The invention further provides methods of making proteins with reduced level of fucosylation, such as antibodies and antibodies made by the methods of the present invention. Such hypofucosylated or nonfucosylated antibodies may find use, for example, in treatment of human disease in which is it therapeutically eneficial to direct antibody dependent cellular cytotoxicity (ADCC) mediated killing of cells expressing the antibody target on their surface, for example in depletion of Tregs in cancer patients using a hypofucosylated or nonfucosylated anti-CTLA-4 antibody.

4.

发明授权
Enantioselective synthesis of pyrroloindole compounds 有权

公开(公告)号：US09969685B2

公开(公告)日：2018-05-15

申请号：US15718453

申请日：2017-09-28

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Michael Anthony Schmidt

IPC分类号： C07D209/10 , C07D209/12 , C07F7/18

CPC分类号： C07D209/10 , C07D209/12 , C07F7/1804

摘要： Compounds according to formula (I) or (II), wherein R1, R2, and R3 are as defined in the specification, are versatile intermediates for the synthesis of DNA minor groove binder-alkylators having a cyclopropapyrroloindole (CPI) or seco-CPI alkylating subunit.

5.

发明公开
SYNTHESIS OF 1,2,5-TRI-O-BENZOYL-3-DIBENZYLAMINO-3-DEOXYRIBOSE AS INTERMEDIATE FOR PRODUCING 3'-AMINO-3'-DEOXYADENOSINE AND 3'-AMINO-3'-DEOXYGUANOSINE AND THE PROTECTED DERIVATIVES THEREOF 审中-公开

公开(公告)号：US20230357306A1

公开(公告)日：2023-11-09

申请号：US17428548

申请日：2020-02-05

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Changxia Yuan , Michael Anthony Schmidt , Adrian Ortiz , Amanda J. Rogers , Jason J. Zhu , Zhongmin Xu , Miao Yu , Eric M. Simmons , Shulin Wu

IPC分类号： C07H19/167 , C07H5/06

CPC分类号： C07H19/167 , C07H5/06

摘要： The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.

6.

发明授权
Synthesis of 1,2,5-tri-o-benzoyl-3-dibenzylamino-3-deoxyribose as intermediate for producing 3′-amino-3′-deoxyadenosine and 3′-amino-3′-deoxyguanosine and the protected derivatives thereof 有权

公开(公告)号：US12060384B2

公开(公告)日：2024-08-13

申请号：US17428548

申请日：2020-02-05

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Changxia Yuan , Michael Anthony Schmidt , Adrian Ortiz , Amanda J. Rogers , Jason J. Zhu , Zhongmin Xu , Miao Yu , Eric M. Simmons , Shulin Wu

IPC分类号： C07H19/167 , C07H5/06

CPC分类号： C07H19/167 , C07H5/06

摘要： The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.

7.

发明授权
Process and intermediates for making tubulysin analogs 有权

公开(公告)号：US10106560B2

公开(公告)日：2018-10-23

申请号：US15623570

申请日：2017-06-15

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Adrian Ortiz , Carlos A. Guerrero , Bin Zheng , Jason J. Zhu , Michael Anthony Schmidt , Michael R. Luzung , Martin D. Eastgate

IPC分类号： C07D417/12 , C07F7/18 , C07D211/28 , C07F7/08

摘要： An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.

8.

发明申请
PROCESS FOR THE PREPARATION OF A CYCLIC DINUCLEOTIDE 有权

公开(公告)号：US20220064205A1

公开(公告)日：2022-03-03

申请号：US17299087

申请日：2019-12-03

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Michael Anthony Schmidt , Bin Zheng Kendall Park , Benjamin M. Cohen , Amanda J. Rogers , Changxia Yuan Warren , Jason J. Zhu , Chao Hang , Daniel S. Treitler , Adam Josep Freitag , Geoffrey Eugene Purdum , Miao Yu , Melda Sezen Edmonds , Siwei Guo

IPC分类号： C07H21/00 , C07H1/00 , C07H19/16 , C07H19/20

摘要： The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.