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    DETECTION OF LCAT ACTIVITY
    5.
    发明申请
    DETECTION OF LCAT ACTIVITY 有权
    检测LCAT活动

    公开(公告)号：US20140024061A1

    公开(公告)日：2014-01-23

    申请号：US13977161

    申请日：2011-12-28

    申请人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    发明人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    IPC分类号： C12Q1/48

    CPC分类号： C12Q1/48

    摘要： The present disclosure relates to methods for detecting and measuring the activity of lecithin:cholesterol acyltransferase (LCAT) in solution (e.g. serum, plasma, cell culture media, aqueous solution) with fluorescent sterol substrates. The present disclosure also relates to a method for evaluating efficacy of a therapeutic agent for stimulating LCAT and for determining endogenous LCAT activity in a patient. Also disclosed are kits that are used to carry out the aforementioned methods and methods.

    摘要翻译： 本公开涉及用荧光甾醇底物检测和测量溶液（例如血清，血浆，细胞培养基，水溶液）中卵磷脂：胆固醇酰基转移酶（LCAT）的活性的方法。 本公开还涉及用于评估用于刺激LCAT并用于确定患者中内源性LCAT活性的治疗剂的功效的方法。 还公开了用于实施上述方法和方法的试剂盒。

    Detection of LCAT activity
    6.
    发明授权
    Detection of LCAT activity 有权
    检测LCAT活动

    公开(公告)号：US08728749B2

    公开(公告)日：2014-05-20

    申请号：US13977161

    申请日：2011-12-28

    申请人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    发明人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    IPC分类号： C12Q1/48

    CPC分类号： C12Q1/48

    摘要： The present disclosure relates to methods for detecting and measuring the activity of lecithin:cholesterol acyltransferase (LCAT) in solution (e.g. serum, plasma, cell culture media, aqueous solution) with fluorescent sterol substrates. The present disclosure also relates to a method for evaluating efficacy of a therapeutic agent for stimulating LCAT and for determining endogenous LCAT activity in a patient. Also disclosed are kits that are used to carry out the aforementioned methods and methods.

    摘要翻译： 本公开涉及用荧光甾醇底物检测和测量溶液（例如血清，血浆，细胞培养基，水溶液）中卵磷脂：胆固醇酰基转移酶（LCAT）的活性的方法。 本公开还涉及用于评估用于刺激LCAT并用于确定患者中内源性LCAT活性的治疗剂的功效的方法。 还公开了用于实施上述方法和方法的试剂盒。

    Methods of treating anemia and red blood cell dysfunction with lecithin cholesterol acyltransferase
    7.
    发明授权
    Methods of treating anemia and red blood cell dysfunction with lecithin cholesterol acyltransferase 有权
    用卵磷脂胆固醇酰基转移酶治疗贫血和红细胞功能障碍的方法

    公开(公告)号：US08492108B2

    公开(公告)日：2013-07-23

    申请号：US13377586

    申请日：2010-06-14

    申请人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    发明人： Bruce J. Auerbach ,  Reynold Homan ,  Brian Krause

    IPC分类号： C12Q1/48

    CPC分类号： A61K38/45 ,  A61K48/00 ,  C12N9/1029 ,  C12Y203/01043 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/415

    摘要： Disclosed are methods for treating conditions characterized by anemia or red blood cells dysfunction by administering an agent that increases the level of endogenous LCAT or LCAT activity. Additionally disclosed are methods of treating conditions wherein red blood cells have reduced function in relation to deformability, oxygenation, increased adhesion and aggregability, reduced nitric oxide function, or decreased life-span, increased free cholesterol, or abnormal phospholipid content. Also disclosed are methods for treating conditions characterized by an abnormal concentration of free cholesterol in red blood cells and methods of normalizing the free cholesterol content of red blood cells.

    摘要翻译： 公开了通过施用增加内源性LCAT或LCAT活性水平的试剂来治疗特征在于贫血或红细胞功能障碍的病症的方法。 另外公开了治疗条件的方法，其中红细胞相对于变形性，氧合，增加的粘附性和聚集性，降低的一氧化氮功能或降低的寿命，增加的游离胆固醇或异常磷脂含量具有降低的功能。 还公开了用于治疗以红细胞中游离胆固醇异常浓度为特征的病症的方法和使血红细胞游离胆固醇含量正常化的方法。