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1.发明申请Pharmaceutical composition for treating and preventing cancer comprising cinnamoni cortex extract and zizyphi fructus extract 审中-公开用于治疗和预防癌症的药物组合物，包括肉桂醛皮质提取物和枸杞子提取物公开(公告)号：US20070160691A1
公开(公告)日：2007-07-12
申请号：US10580166
申请日：2004-12-23
申请人： Byoung-Mog Kwon , Kwang-Hee Son , Dong Han , Yung-Hee Kho , Hyo-Kon Chun , Hwan Kim , Chang-Woo Lee
发明人： Byoung-Mog Kwon , Kwang-Hee Son , Dong Han , Yung-Hee Kho , Hyo-Kon Chun , Hwan Kim , Chang-Woo Lee
CPC分类号： A61K36/54 , A23L33/105 , A23V2002/00 , A61K31/12 , A61K31/19 , A61K31/56 , A61K36/725 , A61K2300/00 , A23V2200/308 , A23V2250/21
摘要： Disclosed is a pharmaceutical composition for treating and preventing cancer, comprising a Cinnamoni Cortex extract and a Zizyphi Fructus extract. The pharmaceutical composition has effects of inducing apoptosis of cancer cells and inhibiting metastasis of cancer cells, as well as having a synergistic effect in inhibiting the growth of cancer cells compared to the separate use of the two extracts. Also, because the two extracts are extracted from natural origins, the pharmaceutical composition has no toxicity and is thus able to be used as a safe anticancer agent having excellent therapeutic efficacy. Further, the pharmaceutical composition is capable of being used as a functional food for preventing and treating cancer.
摘要翻译： 公开了一种用于治疗和预防癌症的药物组合物，其包含肉桂醛皮质提取物和Zizyphi Fructus提取物。 药物组合物具有诱导癌细胞凋亡和抑制癌细胞转移的作用，并且与单独使用两种提取物相比，具有抑制癌细胞生长的协同作用。 此外，由于两种提取物是从天然来源提取的，所以药物组合物没有毒性，因此能够作为具有优异疗效的安全抗癌剂使用。 此外，药物组合物能够用作预防和治疗癌症的功能性食品。
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2.发明申请Pharmaceutical composition containing obovatol as an active ingredient for the prevention and treatment of neurodegenerative diseases 审中-公开含有挥发酚作为预防和治疗神经变性疾病的有效成分的药物组合物公开(公告)号：US20070185215A1
公开(公告)日：2007-08-09
申请号：US11401341
申请日：2006-04-10
申请人： Byoung-Mog Kwon , Kwang-Hee Son , Dong Han , Ji-Min Lee , Kyoungho Suk , Su Hong , Jiyeon Ock
发明人： Byoung-Mog Kwon , Kwang-Hee Son , Dong Han , Ji-Min Lee , Kyoungho Suk , Su Hong , Jiyeon Ock
IPC分类号： A61K31/075
CPC分类号： A61K31/075 , A61K36/57
摘要： Disclosed herein a pharmaceutical composition, comprising obovatol as an active ingredient, for the prevention and treatment of neurodegenerative diseases. Having superior inhibitory activity against the production of neurotoxic nitric oxides, the obovatol isolated and purified from Magnoliaceae can be used as active ingredient for a pharmaceutical composition or a neuroprotective agent for the prevention and treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
摘要翻译： 本文公开了一种药物组合物，其包含用作预防和治疗神经退行性疾病的作为活性成分的高效醇。 对于神经毒性一氧化氮的生产具有优异的抑制活性，从木兰科分离和纯化的浮游动物可以用作药物组合物或神经保护剂的有效成分，用于预防和治疗神经变性疾病，例如阿尔茨海默病，帕金森氏病， 和多发性硬化症。
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公开(公告)号：US20160173993A1
公开(公告)日：2016-06-16
申请号：US14832535
申请日：2015-08-21
申请人： Dong Han , Chua TiongKee , Roger Tay , Tan Siew Seong
发明人： Dong Han , Chua TiongKee , Roger Tay , Tan Siew Seong
CPC分类号： H04R19/04 , H04R3/00 , H04R3/02 , H04R19/005 , H04R2410/03
摘要： A circuit module for a silicon condenser microphone of the present disclosure includes a transducer, a charge pump, an isolator, a first amplifier, a second amplifier, a reaction circuit, a first bias circuit, and a second bias circuit. The charge pump electrically connects to an input port of the transducer, and an output port of the transducer electrically connects to an input port of the first amplifier via the isolator. An output port of the first amplifier electrically connects to an input port of the second amplifier. The reaction circuit is arranged between the output port of the first amplifier and the input port of the transducer. The isolator isolates the direct-current components of the first electrical signal, and therefore, the oscillations of the direct-current components will not affect the performance of the first amplifier.
摘要翻译： 本公开的用于硅电容式麦克风的电路模块包括换能器，电荷泵，隔离器，第一放大器，第二放大器，反应电路，第一偏置电路和第二偏置电路。 电荷泵电连接到换能器的输入端口，并且换能器的输出端口通过隔离器电连接到第一放大器的输入端口。 第一放大器的输出端口电连接到第二放大器的输入端口。 反应电路设置在第一放大器的输出端口和换能器的输入端口之间。 隔离器隔离第一电信号的直流分量，因此直流分量的振荡不会影响第一放大器的性能。
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公开(公告)号：US08507491B2
公开(公告)日：2013-08-13
申请号：US13060426
申请日：2009-08-24
申请人： Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
发明人： Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
IPC分类号： A61K31/501 , A61K31/4725 , A61K31/4439 , A61K31/497 , A61K31/472 , A61K31/4427 , A61P35/00
CPC分类号： C07D401/12 , A61K31/47 , C07D217/04 , C07D217/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07D513/04
摘要： The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要翻译： 本发明提供了调节刺猬蛋白信号通路活性的方法，化合物和组合物。 特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或GIi功能增益等表型引起的异常生长状态的方法，包括使细胞接触 与足量的式（I）化合物反应。
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公开(公告)号：US20130079328A1
公开(公告)日：2013-03-28
申请号：US13701982
申请日：2011-06-28
申请人： Dai Cheng , Guobao Zhang , Dong Han , Wenqi Gao , Shifeng Pan , Lichun Shen , Rajender Reddy Leleti
发明人： Dai Cheng , Guobao Zhang , Dong Han , Wenqi Gao , Shifeng Pan , Lichun Shen , Rajender Reddy Leleti
IPC分类号： C07D417/14 , A61K45/06 , A61K31/541 , C07D237/08 , A61K31/50
CPC分类号： C07D417/14 , A61K31/50 , A61K31/541 , A61K45/06 , C07D213/56 , C07D237/08 , C07D279/12 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1, R2, R3 are as defined herein.
摘要翻译： 本发明涉及使用具有式（1）和（3）的化合物调节Wnt信号通路的组合物和方法：其中A，B，Y和Z均表示环，并且R 1，R 2，R 3如本文所定义。
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7.发明申请公开(公告)号：US20120196849A1
公开(公告)日：2012-08-02
申请号：US13443631
申请日：2012-04-10
申请人： Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
发明人： Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
IPC分类号： A61K31/553 , C07D295/26 , C07D295/155 , C07D401/14 , C07D401/04 , A61K31/5375 , A61K31/5377 , A61K31/551 , A61K31/55 , A61K31/496 , A61P1/18 , A61P13/08 , A61P35/00 , C12N5/09 , C07D413/04
CPC分类号： C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译： 本发明提供了一种调节刺猬蛋白信号通路活性的方法。 特别地，本发明提供了一种抑制由诸如Ptc功能丧失，hedgehog功能增益，平滑增益功能或Gli功能增益等表现形成的异常生长状态的方法，包括使细胞接触 与足量的式I化合物反应。
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8.发明申请N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS 有权用作WNT信号调节剂的N-（异氟烷基）亚甲基，2-（异丁基）亚芳基取代的乙酰胺公开(公告)号：US20110237573A1
公开(公告)日：2011-09-29
申请号：US13132294
申请日：2010-03-01
申请人： Dai Cheng , Guobao Zhang , Dong Han , Wenqi Gao , Shifeng Pan
发明人： Dai Cheng , Guobao Zhang , Dong Han , Wenqi Gao , Shifeng Pan
IPC分类号： A61K31/541 , C07D417/12 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/4439 , A61K31/444 , A61K31/501 , A61K31/5377 , A61K31/497 , C12N5/071 , A61P19/02 , A61P25/16 , A61P27/02 , A61P7/10 , A61P35/00 , A61P17/02 , A61P3/00 , A61P35/02
CPC分类号： A61K31/541 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A1, A2, B, Y and Z all represent rings.
摘要翻译： 本发明涉及式1和化合物2以及使用这些化合物调节Wnt信号通路的方法，其中A1，A2，B，Y和Z都代表环。
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公开(公告)号：US20110152282A1
公开(公告)日：2011-06-23
申请号：US13060426
申请日：2009-08-24
申请人： Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
发明人： Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
IPC分类号： A61K31/501 , C07D401/12 , C07D409/14 , C07D471/04 , C07D401/14 , C07D473/00 , A61K31/4725 , A61K31/519 , A61K31/4375 , A61K31/52 , A61P35/00 , A61P17/06
CPC分类号： C07D401/12 , A61K31/47 , C07D217/04 , C07D217/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07D513/04
摘要： The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要翻译： 本发明提供了调节刺猬蛋白信号通路活性的方法，化合物和组合物。 特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或GIi功能增益等表型引起的异常生长状态的方法，包括使细胞接触 与足量的式（I）化合物反应。
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