公开(公告)号：US10344059B2

公开(公告)日：2019-07-09

申请号：US15679671

申请日：2017-08-17

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Hye Won Kim ,  Jin Sook Chang ,  In Hwa Yoo

IPC: C12N15/63 ,  C12N15/52 ,  C12N9/16 ,  C12N9/00 ,  C07K14/245 ,  C12P13/12 ,  C12P13/06 ,  C12N9/04 ,  C12N9/10 ,  C12P13/00

Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.

公开(公告)号：US09243268B2

公开(公告)日：2016-01-26

申请号：US14365571

申请日：2012-12-14

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Byeong Cheol Song ,  Jin Sook Chang ,  Jae Hyun Jo ,  Hye Won Kim

IPC: C12P13/12 ,  C12N9/10

CPC classification number: C12P13/12 ,  C12N9/1085 ,  C12Y205/01065

Abstract: The present invention relates to a method for producing cysteine or derivatives thereof using novel O-phosphoserine sulfhydrylase. According to the present invention, a method for producing cysteine by novel O-phosphoserine sulfhydrylase (OPSS) using O-phosphoserine as a substrate is provided, and this method is advantageous in that cysteine can be simply and environmental-friendly produced in a high yield.

Abstract translation: 本发明涉及使用新型O-磷酸丝氨酸巯基酸酶制备半胱氨酸或其衍生物的方法。 根据本发明，提供了使用O-磷酸丝氨酸作为底物的新型O-磷酸丝氨酸巯基化酶（OPSS）制备半胱氨酸的方法，该方法的优点在于半胱氨酸可以以高产率制备简单且环保 。

公开(公告)号：US20150004657A1

公开(公告)日：2015-01-01

申请号：US14365571

申请日：2012-12-14

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Byeong Cheol Song ,  Jin Sook Chang ,  Jae Hyun Jo ,  Hye Won Kim

IPC: C12P13/12

CPC classification number: C12P13/12 ,  C12N9/1085 ,  C12Y205/01065

Abstract: The present invention relates to a method for producing cysteine or derivatives thereof using novel O-phosphoserine sulfhydrylase. According to the present invention, a method for producing cysteine by novel O-phosphoserine sulfhydrylase (OPSS) using O-phosphoserine as a substrate is provided, and this method is advantageous in that cysteine can be simply and environmental-friendly produced in a high yield.

Abstract translation: 本发明涉及使用新型O-磷酸丝氨酸巯基酸酶制备半胱氨酸或其衍生物的方法。 根据本发明，提供了使用O-磷酸丝氨酸作为底物的新型O-磷酸丝氨酸巯基化酶（OPSS）制备半胱氨酸的方法，该方法的优点在于半胱氨酸可以以高产率制备简单且环保 。

公开(公告)号：US20190284247A1

公开(公告)日：2019-09-19

申请号：US16423986

申请日：2019-05-28

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Hye Won Kim ,  Jin Sook Chang ,  In Hwa Yoo

IPC: C07K14/245 ,  C12P13/00 ,  C12P13/06 ,  C12N15/63 ,  C12N9/04 ,  C12N15/52 ,  C12N9/16 ,  C12N9/10 ,  C12P13/12

Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.

公开(公告)号：US10378031B2

公开(公告)日：2019-08-13

申请号：US15765577

申请日：2016-10-13

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Imsang Lee ,  Sung Kwang Son ,  Hyeryun Yoo ,  Jae Hee Lee ,  Joo Hee Lee ,  Jin Sook Chang ,  Jin-Geun Choi ,  So Young Kim ,  Yong Uk Shin

IPC: C12N9/10 ,  C12N15/70 ,  C12P13/12

Abstract: The present disclosure relates to a novel O-acetylhomoserine sulfhydrylase variant, a polynucleotide encoding the same, a vector comprising the polynucleotide, a strain capable of expressing the variant, and a method for producing L-methionine using the variant.

公开(公告)号：US09834491B2

公开(公告)日：2017-12-05

申请号：US14219307

申请日：2014-03-19

Applicant: CJ Cheiljedang Corporation

Inventor： Han Won Lee ,  Young Lyeol Yang ,  So Young Kim ,  Yong Uk Shin ,  Jin Sook Chang ,  Hye Won Um ,  Young Hyoung Goh ,  Sung Hoo Jhon

IPC: C07C1/24 ,  C07D307/22 ,  C07D307/20 ,  C07D307/08 ,  C07D207/12 ,  C07C29/09 ,  C07C29/149 ,  C07C29/48

CPC classification number: C07C1/24 ,  C07C29/09 ,  C07C29/149 ,  C07C29/48 ,  C07C2529/40 ,  C07D207/12 ,  C07D307/08 ,  C07D307/20 ,  C07D307/22 ,  C07C11/04 ,  C07C31/12 ,  C07C31/08 ,  C07C31/202

Abstract: The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.

公开(公告)号：US11773417B2

公开(公告)日：2023-10-03

申请号：US16971713

申请日：2019-06-26

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ji Young Kim ,  Myung Geun Park ,  Hye Min Park ,  Jung Woon Choi ,  Sang Min Park ,  Sang Young Bae ,  Jin Sook Chang

IPC: C12P7/64 ,  C12N1/12 ,  C12R1/89

CPC classification number: C12P7/64 ,  C12N1/12 ,  C12N1/125 ,  C12R2001/89

Abstract: The present disclosure relates to strains of Thraustochytrium genus, including a high content of polyunsaturated fatty acids, and a method of producing a biomass using the same. According to the novel CJM01 microalgae of Thraustochytrium genus of the present disclosure, the content of lipids in the biomass and the content of unsaturated fatty acid such as docosahexaenoic acid in the biomass are high, so that the microalgae itself, a biomass produced by the culturing and fermentation of microalgae, a condensate of the biomass, and a dried product of the biomass are very useful as a feed composition.

公开(公告)号：US11180784B2

公开(公告)日：2021-11-23

申请号：US16344205

申请日：2019-01-25

Applicant: CJ Cheiljedang Corporation

Inventor： Seung-ju Son ,  Byoung Hoon Yoon ,  Kwang Woo Lee ,  Seon Hye Kim ,  Hyo Jeong Byun ,  Jin Sook Chang ,  Hyung Joon Kim ,  Yong Uk Shin

IPC: C12P13/08 ,  C07K14/34

Abstract: A microorganism of the genus Corynebacterium producing L-amino acids, and a method of producing L-amino acids using the same.

公开(公告)号：US10961554B2

公开(公告)日：2021-03-30

申请号：US16639364

申请日：2019-03-27

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ji Yeon Lee ,  Jin Sook Chang ,  Hyung Joon Kim ,  Byoung Hoon Yoon ,  Sun Hyoung Choi ,  Yunjung Choi

IPC: C12P13/04 ,  C12N9/10 ,  C12N9/14 ,  C12N15/77 ,  C12N1/21 ,  C12P13/14

Abstract: The present disclosure relates to a novel promoter and a method for producing L-amino acids using the promoter, and more specifically, to a novel polynucleotide having promoter activity, a vector and a microorganism of the genus Corynebacterium comprising the polynucleotide, a method for producing L-amino acids and a fermented composition using the microorganism, and a fermented composition.

公开(公告)号：US10752659B2

公开(公告)日：2020-08-25

申请号：US16423986

申请日：2019-05-28

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Hye Won Kim ,  Jin Sook Chang ,  In Hwa Yoo

IPC: C12N15/63 ,  C12N15/52 ,  C12N9/16 ,  C12N9/00 ,  C07K14/245 ,  C12P13/12 ,  C12P13/06 ,  C12N9/04 ,  C12N9/10 ,  C12P13/00

Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.