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1.发明授权公开(公告)号：US11053524B2
公开(公告)日：2021-07-06
申请号：US16246082
申请日：2019-01-11
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Kyoung Min Lee , Hee Kyoung Jung , Young Lyeol Yang , Hye Won Um , Chang Gyeom Kim , Hong Xian Li , Su Jin Park , Jong Hyun Yoon , Baek Seok Lee , Sun Young Lee
Abstract: The present invention relates to a recombinant microorganism capable of producing putrescine, in which the microorganism is modified to have enhanced NCgl2522 activity, thereby producing putrescine in a high yield, and a method for producing putrescine using the microorganism.
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公开(公告)号：US09834491B2
公开(公告)日：2017-12-05
申请号：US14219307
申请日：2014-03-19
Applicant: CJ Cheiljedang Corporation
Inventor： Han Won Lee , Young Lyeol Yang , So Young Kim , Yong Uk Shin , Jin Sook Chang , Hye Won Um , Young Hyoung Goh , Sung Hoo Jhon
IPC: C07C1/24 , C07D307/22 , C07D307/20 , C07D307/08 , C07D207/12 , C07C29/09 , C07C29/149 , C07C29/48
CPC classification number: C07C1/24 , C07C29/09 , C07C29/149 , C07C29/48 , C07C2529/40 , C07D207/12 , C07D307/08 , C07D307/20 , C07D307/22 , C07C11/04 , C07C31/12 , C07C31/08 , C07C31/202
Abstract: The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.
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3.发明申请RECOMBINANT MICROORGANISM HAVING IMPROVED PUTRESCINE PRODUCING ABILITY AND METHOD FOR PRODUCING PUTRESCINE BY USING SAME 有权具有改进的PUTRESCINE生产能力的重组微生物和使用它们生产PUTRESCINE的方法公开(公告)号：US20140363859A1
公开(公告)日：2014-12-11
申请号：US14373265
申请日：2013-01-21
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Kyoung Min Lee , Seon Hye Kim , Hye Won Um , Min Sun Kang , Su Jin Choi , Hee Kyoung Jung , Sung Hoo Jhon , Hongxian Li , Won Sik Gwak , Chong Ho Lee , Young Lyeol Yang
CPC classification number: C12N15/77 , C12N15/52 , C12P13/001
Abstract: The present invention relates to a recombinant microorganism having enhanced ability to produce putrescine at high yield, wherein the activity of NCgl0101 is weakened in a microorganism of genus Corynebacterium that has been modified to produce putrescine, and a method for producing putrescine using the same.
Abstract translation: 本发明涉及一种能够以高产率产生腐胺的能力增强的重组微生物，其中在已经被修饰以产生腐胺的棒状杆菌属的微生物中，NCgl0101的活性被削弱，以及使用其的腐胺的制备方法。
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公开(公告)号：US11053525B2
公开(公告)日：2021-07-06
申请号：US15739699
申请日：2016-03-29
Applicant: CJ Cheiljedang Corporation
Inventor： Hee Kyoung Jung , Hye Won Um , Hong Xian Li , Su Jin Park , Young Lyeol Yang , Kyoung Min Lee , Hyo Hyoung Lee
Abstract: The present invention relates to a recombinant microorganism for producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same. Specifically, the present invention relates to a microorganism of the genus Corynebacterium capable of producing putrescine or ornithine, in which an activity of the transcriptional regulator of sugar metabolism (SugR) is weakened, an activity of the citrate synthase (GltA) is enhanced, or both are applied; and a method for producing putrescine or ornithine using the same.
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公开(公告)号：US10801047B2
公开(公告)日：2020-10-13
申请号：US16632084
申请日：2018-07-19
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Kyoung Min Lee , Sung Gun Lee , Seon Hye Kim , Kyungsu Na , Hong Xian Li , Hyun-jung Bae , Young Lyeol Yang , Hye Won Um , Hyo Hyoung Lee
IPC: C12P13/00
Abstract: The present disclosure relates to a putrescine-producing microorganism of the genus Corynebacterium, and a method of producing putrescine using the same.
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Patent Agency Ranking
6.发明申请Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms 有权由微生物生产的O-酰基高丝氨酸生产生物基高丝氨酸内酯和生物有机酸的方法公开(公告)号：US20140296466A1
公开(公告)日：2014-10-02
申请号：US14219307
申请日：2014-03-19
Applicant: CJ Cheiljedang Corporation
Inventor： Han Won Lee , Young Lyeol Yang , So Young Kim , Yong Uk Shin , Jin Sook Chang , Hye Won Um , Young Hyoung Goh , Sung Hoo Jhon
IPC: C07C29/147 , C07D307/20 , C07C1/24 , C07D207/12 , C08F110/02 , C07C29/09 , C07D307/22 , C07D307/08
CPC classification number: C07C1/24 , C07C29/09 , C07C29/149 , C07C29/48 , C07C2529/40 , C07D207/12 , C07D307/08 , C07D307/20 , C07D307/22 , C07C11/04 , C07C31/12 , C07C31/08 , C07C31/202
Abstract: The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.
Abstract translation: 本发明涉及通过在酸催化剂存在下由微生物产生的O-酰基高丝氨酸的水解生产生物基高丝氨酸内酯和生物基有机酸的方法。 根据本发明，由微生物生产的O-酰基高丝氨酸用作生产1,4-丁二醇，γ-丁内酯，四氢呋喃等的工业用高原料。 由微生物生产的O-酰基高丝氨酸可代替常规的石化产品，可以解决环境问题，包括污染物的排放和自然资源的枯竭，并可以不断更新，以免自然资源枯竭。
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公开(公告)号：US11365400B2
公开(公告)日：2022-06-21
申请号：US17074203
申请日：2020-10-19
Applicant: CJ Cheiljedang Corporation
Inventor： Su Jin Park , Young Lyeol Yang , Hye Won Um , Hong Xian Li , Kyoung Min Lee , Baek Seok Lee , Hyo Hyoung Lee , Hee Kyoung Jung
IPC: C12N9/10 , C12N9/80 , C12P13/00 , C12N15/52 , C12N1/00 , C12N15/00 , C12N9/12 , C12N9/88 , C12N9/00 , C12P13/10
Abstract: Disclosed is a modified microorganism producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same.
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公开(公告)号：US10316339B2
公开(公告)日：2019-06-11
申请号：US15031706
申请日：2014-10-22
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Su Jin Choi , So Young Kim , Chang Il Seo , Yong Uk Shin , Young Lyeol Yang , Hye Won Um , Hye Min Park , Sung Hoo Jhon , Byung Hoon Jung
Abstract: The present invention relates to a polypeptide having a resistant to feedback inhibition by methionine and an activity of homoserine O-succinyltransferase, a O-succinyl homoserine-producing microorganism expressing the polypeptide, and a method for producing O-succinyl homoserine using the same.
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9.发明授权Recombinant microorganism having an enhanced ability to produce putrescine and a method for producing putrescine using the same 有权具有增强的腐胺生产能力的重组微生物和使用该腐胺的腐胺的制备方法公开(公告)号：US09290771B2
公开(公告)日：2016-03-22
申请号：US14373265
申请日：2013-01-21
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Kyoung Min Lee , Seon Hye Kim , Hye Won Um , Min Sun Kang , Su Jin Choi , Hee Kyoung Jung , Sung Hoo Jhon , Hongxian Li , Won Sik Gwak , Chong Ho Lee , Young Lyeol Yang
CPC classification number: C12N15/77 , C12N15/52 , C12P13/001
Abstract: The present invention relates to a recombinant microorganism having enhanced ability to produce putrescine at high yield, wherein the activity of NCg10101 is weakened in a microorganism of genus Corynebacterium that has been modified to produce putrescine, and a method for producing putrescine using the same.
Abstract translation: 本发明涉及一种能够以高产率产生腐胺的能力增强的重组微生物，其中NCg10101的活性在经过改良以产生腐胺的棒状杆菌属的微生物中被削弱，以及使用其的腐胺的制备方法。
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公开(公告)号：US10450262B2
公开(公告)日：2019-10-22
申请号：US15572381
申请日：2016-05-04
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Won Sik Gwak , Hong Xian Li , Hyun Ju Won , Hyo Hyoung Lee , Kyung Su Na , Su Jin Park , Young Lyeol Yang , Hye Won Um , Chang Yub Oh , Kyoung Min Lee
IPC: C07C209/86 , C07C211/09 , B01D3/14 , C07C209/84 , C12P13/00
Abstract: A method for purifying 1,4-diaminobutane comprising the steps of: separating a second composition including carbonate salt of 1,4-diaminobutane from a first composition including carbonate salt of 1,4-diaminobutane by distillation; and removing carbonate from carbonate salt of 1,4-diaminobutane included in the second composition to recover 1,4-diaminobutane.
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