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公开(公告)号：US11407983B2
公开(公告)日：2022-08-09
申请号：US16534130
申请日：2019-08-07
Applicant: CJ CheilJedang Corporation
Inventor： Ji Sun Lee , Dong Eun Chang , So Young Kim
Abstract: A nucleic acid molecule comprising a variant rpoC coding sequence is disclosed. The variant rpoC coding sequence encodes a variant RpoC which regulates copy number of a plasmid. Also disclosed are a recombinant microorganism comprising the nucleic acid molecule, a method for regulating copy number of a subject vector in the recombinant microorganism, and a method for making a target product by use of the recombinant microorganism.
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公开(公告)号：US10221434B2
公开(公告)日：2019-03-05
申请号：US15031707
申请日：2014-10-22
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Chang Il Seo , So Young Kim , Yong Uk Shin , Kwang Ho Na , Hye Won Um , In Kyung Heo
Abstract: The present invention relates to a polypeptide which is resistant to feedback inhibition by methionine and has an activity of homoserine O-succinyltransferase, a microorganism for producing O-succinylhomoserine which expresses the polypeptide, and a method for producing O-succinylhomoserine using the same.
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3.发明授权Microorganisms for production of O-succinylhomoserine and method for production of O-succinylhomoserine using the same 有权用于生产O-琥珀酰高丝氨酸的微生物及使用其的O-琥珀酰高丝氨酸的生产方法公开(公告)号：US09593353B2
公开(公告)日：2017-03-14
申请号：US15031703
申请日：2014-10-22
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Su Jin Choi , So Young Kim , Chang Il Seo , Yong Uk Shin , Young Lyeol Yang , Hye Won Um , Hye Min Park , Sung Hoo Jhon , Byung Hoon Jung
CPC classification number: C12P13/06 , C12N9/1029 , C12Y203/01046 , Y02P20/52
Abstract: The present invention relates to a polypeptide having a resistant to feedback inhibition by methionine and an activity of homoserine O-succinyltransferase, a O-succinyl homoserine-producing microorganism expressing the polypeptide, and a method for producing O-succinyl homoserine using the same.
Abstract translation: 本发明涉及具有抗甲硫氨酸反馈抑制和高丝氨酸O-琥珀酰基转移酶的活性的多肽，表达该多肽的产生O-琥珀酰高丝氨酸的微生物的活性，以及使用该多肽产生O-琥珀酰高丝氨酸的方法。
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公开(公告)号：US10597686B2
公开(公告)日：2020-03-24
申请号：US16514777
申请日：2019-07-17
Applicant: CJ Cheiljedang Corporation
Inventor： Jee Yeon Bae , Ji Hyun Shim , Hyun Ah Kim , Juhee Seo , Yong Uk Shin , Jae Hee Lee , Sang Kyoum Kim , So Young Kim
IPC: C12P13/06 , C12P13/12 , C12N15/70 , C07K14/245
Abstract: The present disclosure relates to a protein having the activity of exporting O-acetylhomoserine and a novel modified protein thereof, a microorganism capable of producing O-acetylhomoserine with enhanced expression of the protein, and a method for producing O-acetylhomoserine using the microorganism.
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公开(公告)号：US10344287B2
公开(公告)日：2019-07-09
申请号：US15323429
申请日：2015-06-30
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Jin Sook Chang , Ju Eun Kim , So Young Kim , Kwang Ho Na , Yong Uk Shin , Jae Min Lee , Jae Hee Lee , In Kyung Heo
IPC: C12N1/20 , C12N9/10 , C12Q1/68 , C12P17/12 , C07H21/04 , C07H21/02 , C07K1/00 , C12N15/70 , C12N15/09 , C12P17/10 , C12N9/06 , C12N15/52
Abstract: The present invention relates to a recombinant microorganism producing quinolinic acid, more particularly, a microorganism producing quinolinic acid and having attenuated activity or eliminated activity of a protein having a sequence of SEQ ID NO: 1 and a method of producing quinolinic acid by using the recombinant microorganism.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20180355389A1
公开(公告)日：2018-12-13
申请号：US15765577
申请日：2016-10-13
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Imsang Lee , Sung Kwang Son , Hyeryun Yoo , Jae Hee Lee , Joo Hee Lee , Jin Sook Chang , Jin-Geun Choi , So Young Kim , Yong Uk Shin
Abstract: The present disclosure relates to a novel O-acetylhomoserine sulfhydrylase variant, a polynucleotide encoding the same, a vector comprising the polynucleotide, a strain capable of expressing the variant, and a method for producing L-methionine using the variant.
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7.发明授权公开(公告)号：US09534240B2
公开(公告)日：2017-01-03
申请号：US14370721
申请日：2013-01-03
Applicant: CJ Cheiljedang Corporation
Inventor： Yong Uk Shin , So Young Kim , In Kyung Heo , Ju Eun Kim , Sung Kwang Son , Jae Hee Lee , Ji Hyun Lee , Chang Gyeom Kim
CPC classification number: C12P17/12 , C12N9/0022 , C12N9/1085 , C12N15/52 , C12N15/62 , C12N15/70 , C12Y104/03016 , C12Y205/01072 , Y02P20/52
Abstract: The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.
Abstract translation: 本发明涉及表达通过接头连接的L-天冬氨酸氧化酶和喹啉酸合成酶的融合蛋白的喹啉酸生产重组微生物及使用其的喹啉酸的制备方法。
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8.发明申请Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms 有权由微生物生产的O-酰基高丝氨酸生产生物基高丝氨酸内酯和生物有机酸的方法公开(公告)号：US20140296466A1
公开(公告)日：2014-10-02
申请号：US14219307
申请日：2014-03-19
Applicant: CJ Cheiljedang Corporation
Inventor： Han Won Lee , Young Lyeol Yang , So Young Kim , Yong Uk Shin , Jin Sook Chang , Hye Won Um , Young Hyoung Goh , Sung Hoo Jhon
IPC: C07C29/147 , C07D307/20 , C07C1/24 , C07D207/12 , C08F110/02 , C07C29/09 , C07D307/22 , C07D307/08
CPC classification number: C07C1/24 , C07C29/09 , C07C29/149 , C07C29/48 , C07C2529/40 , C07D207/12 , C07D307/08 , C07D307/20 , C07D307/22 , C07C11/04 , C07C31/12 , C07C31/08 , C07C31/202
Abstract: The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.
Abstract translation: 本发明涉及通过在酸催化剂存在下由微生物产生的O-酰基高丝氨酸的水解生产生物基高丝氨酸内酯和生物基有机酸的方法。 根据本发明，由微生物生产的O-酰基高丝氨酸用作生产1,4-丁二醇，γ-丁内酯，四氢呋喃等的工业用高原料。 由微生物生产的O-酰基高丝氨酸可代替常规的石化产品，可以解决环境问题，包括污染物的排放和自然资源的枯竭，并可以不断更新，以免自然资源枯竭。
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公开(公告)号：US10316339B2
公开(公告)日：2019-06-11
申请号：US15031706
申请日：2014-10-22
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Su Jin Choi , So Young Kim , Chang Il Seo , Yong Uk Shin , Young Lyeol Yang , Hye Won Um , Hye Min Park , Sung Hoo Jhon , Byung Hoon Jung
Abstract: The present invention relates to a polypeptide having a resistant to feedback inhibition by methionine and an activity of homoserine O-succinyltransferase, a O-succinyl homoserine-producing microorganism expressing the polypeptide, and a method for producing O-succinyl homoserine using the same.
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10.发明申请公开(公告)号：US20150037850A1
公开(公告)日：2015-02-05
申请号：US14370721
申请日：2013-01-03
Applicant: CJ Cheiljedang Corporation
Inventor： Yong Uk Shin , So Young Kim , In Kyung Heo , Ju Eun Kim , Sung Kwang Son , Jae Hee Lee , Ji Hyun Lee , Chang Gyeom Kim
CPC classification number: C12P17/12 , C12N9/0022 , C12N9/1085 , C12N15/52 , C12N15/62 , C12N15/70 , C12Y104/03016 , C12Y205/01072 , Y02P20/52
Abstract: The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.
Abstract translation: 本发明涉及表达通过接头连接的L-天冬氨酸氧化酶和喹啉酸合成酶的融合蛋白的喹啉酸生产重组微生物及使用其的喹啉酸的制备方法。
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