公开(公告)号：US06932939B2

公开(公告)日：2005-08-23

申请号：US10855198

申请日：2004-05-27

申请人： Can Özbal ,  Ian W. Hunter ,  John Linton

发明人： Can Özbal ,  Ian W. Hunter ,  John Linton

IPC分类号： G01N27/62 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C40B60/14 ,  G01N1/00 ,  G01N1/36 ,  G01N21/33 ,  G01N21/64 ,  G01N21/65 ,  G01N21/77 ,  G01N21/78 ,  G01N30/16 ,  G01N30/24 ,  G01N30/46 ,  G01N30/62 ,  G01N30/72 ,  G01N30/84 ,  G01N35/00 ,  G01N35/10 ,  B01D15/08

CPC分类号： G01N30/466 ,  B01F5/0085 ,  B01F13/0059 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00387 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00515 ,  B01J2219/00518 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01L3/0262 ,  B01L3/0268 ,  B01L3/505 ,  B01L3/5085 ,  B01L2300/0812 ,  B01L2300/0845 ,  C40B60/14 ,  G01N30/24 ,  G01N30/7233 ,  G01N30/7266 ,  G01N30/84 ,  G01N35/00009 ,  G01N35/1095 ,  G01N2030/628 ,  G01N2030/8417 ,  G01N2035/1037 ,  G01N2035/1046 ,  Y10T436/115831 ,  G01N30/18

摘要： A system and method high throughput sample preparation and analysis using column chromatography. Each port in a plurality of ports has a port input that interfaces with a first fluid source and a port output. A fluidic circuit is coupled to each port output and to a second fluid source, the fluidic circuit for controlling fluid flow from the plurality of ports and the second fluid source. The fluidic circuit is also coupled to a plurality of chromatography columns. An interface to an analyzer receives output from at least one of the plurality of chromatography columns. The plurality of chromatography columns is moved relative to the analyzer via a translation stage, such that sample output from one of the plurality of chromatography columns can be selectively presented to the analyzer.

摘要翻译： 一种使用柱色谱法的高通量样品制备和分析的系统和方法。 多个端口中的每个端口具有与第一流体源和端口输出接口的端口输入。 流体回路耦合到每个端口输出端和第二流体源，流体回路用于控制来自多个端口和第二流体源的流体流。 流体回路还耦合到多个色谱柱。 分析仪的界面接收至少一个色谱柱的输出。 多个色谱柱经由平移台相对于分析器移动，使得从多个色谱柱中的一个色谱柱输出的样品可以选择性地呈现给分析器。

公开(公告)号：US07100460B2

公开(公告)日：2006-09-05

申请号：US10821124

申请日：2004-04-08

申请人： Can Özbal

发明人： Can Özbal

IPC分类号： B01L3/02

CPC分类号： G01N35/1079

摘要： In accordance with an illustrative embodiment of the invention, a system for obtaining a fluidic sample from a container is presented. The container defines a volume for holding the sample, the volume being closed by a seal. An outer tube has a proximal end and a distal end, the proximal end shaped to permit piercing the seal. An inner tube has an end region axially movable within the outer tube between a piercing position, wherein an end of the inner tube in the end region is retracted from the proximal end of the outer tube, and a transmission position, wherein the end of the inner tube extends axially beyond the proximal end of the outer tube. The outer tube and the inner tube form a tube assembly. At least one of the tube assembly and the container can be moved to cause the outer tube to pierce the seal and, after the seal is pierced, the inner tube can be used in the transmission position to permit fluid transfer with respect to the volume.

摘要翻译： 根据本发明的说明性实施例，提出了一种用于从容器获得流体样品的系统。 容器限定用于保持样品的体积，体积被密封封闭。 外管具有近端和远端，近端成形为允许刺穿密封。 内管具有端部区域，该端部区域可在外管内在刺穿位置之间轴向移动，其中端部区域中的内管的端部从外管的近端缩回，并且传输位置， 内管轴向延伸超出外管的近端。 外管和内管形成管组件。 管组件和容器中的至少一个可以移动以使外管刺穿密封件，并且在密封件被刺穿之后，内管可用于变速器位置以允许流体相对于体积传递。