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公开(公告)号：US07481212B2
公开(公告)日：2009-01-27
申请号：US10698025
申请日：2003-10-30
IPC分类号： A61M11/00
CPC分类号： B65D83/54 , A61M15/009
摘要： An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.
摘要翻译： 雾化装置包括容纳药物制剂的容器，药物制剂包含活性剂和推进剂。 雾化装置还包括与容器连通的计量室，计量室适于容纳计量量的药物制剂，阀，以允许计量量的药物制剂在计量室内从计量腔室释放时，阀门为 以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。 在一个版本中，计量室的尺寸设定为使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。
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公开(公告)号：US08079361B2
公开(公告)日：2011-12-20
申请号：US12337584
申请日：2008-12-17
IPC分类号： A61M11/00
CPC分类号： B65D83/54 , A61M15/009
摘要： An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.
摘要翻译： 雾化装置包括容纳药物制剂的容器，药物制剂包含活性剂和推进剂。 雾化装置还包括与容器连通的计量室，计量室适于容纳计量量的药物制剂，阀，以允许计量量的药物制剂在计量室内从计量腔室释放时，阀门为 以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。 在一个版本中，计量室的尺寸设定为使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。
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公开(公告)号：US20090095289A1
公开(公告)日：2009-04-16
申请号：US12337584
申请日：2008-12-17
CPC分类号： B65D83/54 , A61M15/009
摘要： An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.
摘要翻译： 雾化装置包括容纳药物制剂的容器，药物制剂包含活性剂和推进剂。 雾化装置还包括与容器连通的计量室，计量室适于容纳计量量的药物制剂，阀，以允许计量量的药物制剂在计量室内从计量腔室释放时，阀门为 以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。 在一个版本中，计量室的尺寸设定为使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。
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公开(公告)号：US20050016533A1
公开(公告)日：2005-01-27
申请号：US10601127
申请日：2003-06-19
申请人： Carlos Schuler , Steve Paboojian , Derrick Tuttle , Adrian Smith , Dennis Rasmussen , Aneesh Bakshi , Andrew Clark , Brian Ward , William Alston , Kevin Nason
发明人： Carlos Schuler , Steve Paboojian , Derrick Tuttle , Adrian Smith , Dennis Rasmussen , Aneesh Bakshi , Andrew Clark , Brian Ward , William Alston , Kevin Nason
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.
摘要翻译： 提供了用于雾化药物制剂的系统和方法。 根据一种方法，当试图吸气时，防止呼吸气体流向肺部。 然后，呼吸道气体突然被允许流向肺部。 呼吸气体的流动然后可用于从容器中提取药物制剂并将药物制剂置于呼吸气体流中以形成气溶胶。
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公开(公告)号：US20050056276A1
公开(公告)日：2005-03-17
申请号：US10734076
申请日：2003-12-10
申请人： Carlos Schuler , William Alston
发明人： Carlos Schuler , William Alston
CPC分类号： A61M15/00 , A61M15/0096 , A61M2205/3306
摘要： An aerosolization device comprises a housing, a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant, and a metering valve. The metering valve is in communication with the reservoir and is moveable into the container to an actuated position where a predetermined amount of the pharmaceutical formulation is released. A contact member is provided in the housing. In one version, the contact member is moveable between a first position and a second position to allow for selective actuation of the metering valve. In another version, the contact member's configuration may be changed to allow for selective actuation of the metering valve.
摘要翻译： 雾化装置包括壳体，容器，其包含储存包含推进剂的药物制剂的储存器和计量阀。 计量阀与储存器连通并且可移动到容器中到达预定量的药物制剂被释放的致动位置。 接触构件设置在壳体中。 在一个版本中，接触构件可在第一位置和第二位置之间移动，以允许选择性地致动计量阀。 在另一个版本中，可以改变接触构件的构造以允许选择性地致动计量阀。
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公开(公告)号：US20050051162A1
公开(公告)日：2005-03-10
申请号：US10698025
申请日：2003-10-30
申请人： Carlos Schuler , Andrew Clark , Kevin Walsh , William Alston
发明人： Carlos Schuler , Andrew Clark , Kevin Walsh , William Alston
CPC分类号： B65D83/54 , A61M15/009
摘要： An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.
摘要翻译： 雾化装置包括容纳药物制剂的容器，药物制剂包含活性剂和推进剂。 雾化装置还包括与容器连通的计量室，计量室适于容纳计量量的药物制剂，阀，以允许计量量的药物制剂在计量室内从计量腔室释放时，阀门为 以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。 在一个版本中，计量室的尺寸设定为使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。
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7.发明申请Systems devices and methods for opening receptacles having a powder to be fluidized 有权用于打开具有要流化的粉末的容器的系统装置和方法公开(公告)号：US20050161041A1
公开(公告)日：2005-07-28
申请号：US10675602
申请日：2003-09-29
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0038 , A61M2202/064 , B67B7/30 , Y10T408/03 , Y10T408/895 , Y10T408/896 , Y10T408/909 , Y10T408/9097
摘要： A method for forming at least one opening in a receptacle comprises the steps of providing a receptacle having a cover with an exterior surface and an interior surface covering a cavity. A cutting mechanism is also provided having at least one blade. The cover is pierced with the blade, and the blade is moved through the cover to cut a portion of the cover and create an opening in the cover to provide access into the cavity. Further, the cut portion curls on top of the exterior surface as the opening is created.
摘要翻译： 一种用于在容器中形成至少一个开口的方法包括以下步骤：提供具有覆盖有外表面和覆盖空腔的内表面的盖的插座。 还提供了具有至少一个叶片的切割机构。 盖子被刀片刺穿，并且刀片移动通过盖子以切割盖子的一部分并且在盖子中形成开口以提供进入腔室的通路。 此外，当产生开口时，切割部分在外表面的顶部卷曲。
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公开(公告)号：US20050051453A1
公开(公告)日：2005-03-10
申请号：US10301820
申请日：2002-11-20
申请人： Carlos Schuler , William Alston , Dennis Rasmussen
发明人： Carlos Schuler , William Alston , Dennis Rasmussen
CPC分类号： B65B7/2878 , B65B7/164 , B65B51/16
摘要： An apparatus is provided for sealing a first layer to a second layer, the second layer comprising one or more cavities adapted to contain a pharmaceutical formulation. The apparatus comprises a roller comprising a heating element, and a surface adapted to support the first and second layers, the surface being translatable relative to the roller. The first layer may be heat sealed to the second layer when contacted by the roller to contain the pharmaceutical formulation within the one or more cavities.
摘要翻译： 提供了用于将第一层密封到第二层的设备，第二层包括适于容纳药物制剂的一个或多个空腔。 该装置包括一个包括加热元件的滚子和适于支撑第一和第二层的表面，该表面可相对于滚子平移。 当与辊接触时，第一层可以热密封到第二层，以在一个或多个空腔内容纳药物制剂。
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公开(公告)号：US20050056275A1
公开(公告)日：2005-03-17
申请号：US10727077
申请日：2003-12-02
申请人： Frank Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
发明人： Frank Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
CPC分类号： B05B11/062 , A61M11/001 , A61M15/002 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M2202/064 , A61M2205/073 , B05B7/1413 , B65D75/366 , B65D2575/362
摘要： A method for aerosolizing a powder utilizes a receptacle having a cavity containing a powder. An access end of an extraction tube is inserted into the cavity, and an inlet opening is formed in the receptacle. A pressurized gas is flowed through the inlet opening, through the cavity and through the extraction tube to move the powder in the cavity into the extraction tube where the powder is entrained in the gas to form an aerosol.
摘要翻译： 用于雾化粉末的方法利用具有包含粉末的空腔的容器。 抽吸管的入口端插入空腔中，并且在容器中形成入口。 加压气体通过入口开口流过空腔并通过抽出管，将空腔中的粉末移动到提取管中，将粉末夹带在气体中形成气溶胶。
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公开(公告)号：US06606992B1
公开(公告)日：2003-08-19
申请号：US09583312
申请日：2000-05-30
申请人： Carlos Schuler , Steve Paboojian , Derrick J. Tuttle , Adrian E. Smith , Dennis R. Rasmussen , Aneesh Bakshi , Andrew Clark , Brian R. S. Ward , William W. Alston, Jr. , Kevin S. Nason
发明人： Carlos Schuler , Steve Paboojian , Derrick J. Tuttle , Adrian E. Smith , Dennis R. Rasmussen , Aneesh Bakshi , Andrew Clark , Brian R. S. Ward , William W. Alston, Jr. , Kevin S. Nason
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.
摘要翻译： 提供了用于雾化药物制剂的系统和方法。 根据一种方法，当试图吸气时，防止呼吸气体流向肺部。 然后，呼吸道气体突然被允许流向肺部。 呼吸气体的流动然后可用于从容器中提取药物制剂并将药物制剂置于呼吸气体流中以形成气溶胶。
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