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18 条记录 (耗时 0.04 秒)

    Flow resistance modulated aerosolized active agent delivery
    3.
    发明授权
    Flow resistance modulated aerosolized active agent delivery 失效
    阻流调制气雾剂活性剂输送

    公开(公告)号：US08408200B2

    公开(公告)日：2013-04-02

    申请号：US09414384

    申请日：1999-10-07

    申请人： Andrew Clark ,  Carlos Schuler ,  Steve Paboojian

    发明人： Andrew Clark ,  Carlos Schuler ,  Steve Paboojian

    IPC分类号： A61M16/00 ,  A61M15/00 ,  A62B9/02

    CPC分类号： A61M15/00 ,  A61M2016/0021 ,  A61M2202/064

    摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.

    摘要翻译： 本发明涉及用于将活性剂制剂递送到人类患者的肺的方法和装置。 活性剂制剂可以是干粉形式，它可以是雾化的，或者它可以与推进剂混合。 活性剂制剂以低吸入流速在初始时期递送给患者，以提高活性剂的生物利用度。

    Dry powder dispersing apparatus and methods for their use
    6.
    发明授权
    Dry powder dispersing apparatus and methods for their use 有权
    干粉分散装置及其使用方法

    公开(公告)号：US06257233B1

    公开(公告)日：2001-07-10

    申请号：US09312434

    申请日：1999-05-14

    申请人： John D. Burr ,  Adrian E. Smith ,  Randy K. Hall ,  Herman Snyder ,  Carlos Schuler ,  George S. Axford ,  Charles Ray

    发明人： John D. Burr ,  Adrian E. Smith ,  Randy K. Hall ,  Herman Snyder ,  Carlos Schuler ,  George S. Axford ,  Charles Ray

    IPC分类号： A61M1500

    CPC分类号： A61M15/0028 ,  A61M15/0036 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/073 ,  B05B11/062

    摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

    摘要翻译： 本发明提供了用于使粉末状药物雾化的各种装置和方法。 在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。 手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。 包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。 包括支架组件以接收容器并将容器连接到雾化机构。 第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。 第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。 如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

    Dry powder dispersing apparatus and methods for their use
    7.
    发明授权
    Dry powder dispersing apparatus and methods for their use 失效
    干粉分散装置及其使用方法

    公开(公告)号：US06901929B2

    公开(公告)日：2005-06-07

    申请号：US10327633

    申请日：2002-12-19

    申请人： John D. Burr ,  Adrian E. Smith ,  Randy K. Hall ,  Herman Snyder ,  Carlos Schuler ,  George S. Axford ,  Charles Ray

    发明人： John D. Burr ,  Adrian E. Smith ,  Randy K. Hall ,  Herman Snyder ,  Carlos Schuler ,  George S. Axford ,  Charles Ray

    IPC分类号： A61K31/505 ,  A61M15/00 ,  B05B11/06 ,  C07D239/70 ,  C07D487/12

    CPC分类号： A61M15/0028 ,  A61M15/0036 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/07 ,  A61M2205/073 ,  B05B11/062

    摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

    摘要翻译： 本发明提供了用于使粉末状药物雾化的各种装置和方法。 在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。 手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。 包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。 包括支架组件以接收容器并将容器连接到雾化机构。 第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。 第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。 如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

    Increased dosage metered dose inhaler
    9.
    发明申请
    Increased dosage metered dose inhaler 有权
    增加剂量计量剂量吸入器

    公开(公告)号：US20050051162A1

    公开(公告)日：2005-03-10

    申请号：US10698025

    申请日：2003-10-30

    申请人： Carlos Schuler ,  Andrew Clark ,  Kevin Walsh ,  William Alston

    发明人： Carlos Schuler ,  Andrew Clark ,  Kevin Walsh ,  William Alston

    IPC分类号： A61M15/00 ,  B65D83/14 ,  A61M11/00

    CPC分类号： B65D83/54 ,  A61M15/009

    摘要： An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.

    摘要翻译： 雾化装置包括容纳药物制剂的容器，药物制剂包含活性剂和推进剂。 雾化装置还包括与容器连通的计量室，计量室适于容纳计量量的药物制剂，阀，以允许计量量的药物制剂在计量室内从计量腔室释放时，阀门为 以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。 在一个版本中，计量室的尺寸设定为使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。