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    Device incorporating a microfluidic chip for separating analyte from a sample
    1.
    发明申请
    Device incorporating a microfluidic chip for separating analyte from a sample 有权
    装有微流体芯片以用于从样品中分离分析物的装置

    公开(公告)号：US20020055167A1

    公开(公告)日：2002-05-09

    申请号：US10006850

    申请日：2001-11-07

    Applicant: Cepheid

    Inventor： Farzad Pourahmadi ,  William A. McMillan ,  Jesus Ching ,  Ronald Chang ,  Lee A. Christel ,  Gregory T.A. Kovacs ,  M. Allen Northrup ,  Kurt E. Petersen

    IPC: C12M001/34

    CPC classification number: C12M47/06 ,  B01L2400/0622 ,  B01L2400/0644

    Abstract: A device for separating an analyte from a fluid sample comprises a cartridge having a sample port and a first flow path extending from the sample port. A microfluidic chip is positioned in the first flow path. The microfluidic chip includes an extraction chamber having an array of microstructures for capturing the analyte from the sample as the sample flows through the extraction chamber and for subsequently releasing the captured analyte into an elution fluid as the elution fluid flows through the extraction chamber. Each of the microstructures has an aspect ratio of at least 2:1. The cartridge also includes a second flow path for eluting the captured analyte from the microfluidic chip, the second flow path diverging from the first flow path after passing through the chip. At least one flow controller directs the sample into the first flow path and the eluted analyte into the second flow path.

    Abstract translation: 用于从流体样品分离分析物的装置包括具有样品端口和从样品端口延伸的第一流动路径的盒。 微流体芯片位于第一流路中。 微流体芯片包括提取室，其具有用于当样品流过提取室时从样品捕获分析物的微结构阵列，并且随着洗脱流体流过提取室，随后将捕获的分析物释放到洗脱液中。 每个微结构具有至少2:1的纵横比。 盒还包括用于从微流体芯片洗脱捕获的分析物的第二流路，第二流路在通过芯片之后从第一流路发散。 至少一个流量控制器将样品引导到第一流动路径中，并将洗脱的分析物引导到第二流动路径中。

    Apparatus and method for cell disruption
    3.
    发明申请
    Apparatus and method for cell disruption 审中-公开
    细胞破裂的装置和方法

    公开(公告)号：US20040200909A1

    公开(公告)日：2004-10-14

    申请号：US10759741

    申请日：2004-01-15

    Applicant: Cepheid

    Inventor： William A. McMillan ,  Farzad Pourahmadi

    IPC: B02C019/12

    CPC classification number: B01L3/502 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M47/06

    Abstract: An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.

    Abstract translation: 用于破坏细胞或病毒的装置包括具有用于保持细胞或病毒的室的容器。 容器包括限定腔室的至少一个柔性壁。 该装置还包括用于冲击柔性壁的外表面的换能器，以在腔室中产生压力波。 该装置还包括用于增加腔室中的压力的​​压力源。 室的加压确保换能器与柔性壁之间的有效耦合。 该装置还可以包括室中的珠子，用于破裂细胞或病毒。

    Multi-channel optical detection system
    4.
    发明申请
    Multi-channel optical detection system 有权
    多通道光学检测系统

    公开(公告)号：US20020109844A1

    公开(公告)日：2002-08-15

    申请号：US10119228

    申请日：2002-04-08

    Applicant: Cepheid

    Inventor： Lee A. Christel ,  M. Allen Northrup ,  Kurt E. Petersen ,  William A. McMillan ,  Gregory T.A. Kovacs ,  Steven J. Young ,  Ronald Chang ,  Douglas B. Dority ,  Raymond T. Herbert ,  Gregory J. Kintz

    IPC: G01N021/64

    CPC classification number: B01L3/508 ,  B01J19/0093 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/042 ,  B01L2300/0809 ,  B01L2300/0858 ,  B01L2300/168 ,  B01L2300/1805 ,  F28D2021/0077 ,  F28F3/12 ,  F28F21/04 ,  F28F2280/10 ,  G01N21/0303 ,  G01N21/0332 ,  G01N2035/00326

    Abstract: An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel null2null having a chamber null10null for holding the mixture. The apparatus also includes a heat-exchanging module null37null having a pair of opposing thermal plates null34A, 34Bnull for receiving the vessel null2null between them and for heating/and or cooling the mixture contained in the vessel. The module null37null also includes optical excitation and detection assemblies null46,48null positioned to optically interrogate the mixture. The excitation assembly null46null includes multiple light sources null100null and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly null48null includes multiple detectors null102null and a second set of filters for detecting light emitted from the chamber null10null in multiple emission wavelength ranges. The optics assemblies null46,48null thus provide a multi-channel system for detecting a plurality of different target analytes in the mixture.

    Abstract translation: 用于热控制和光学询问反应混合物的装置包括具有用于保持混合物的室[10]的容器[2]。 该装置还包括具有一对相对的热板[34A，34B]的热交换模块[37]，用于在它们之间接收容器[2]并用于加热和/或冷却容纳在容器中的混合物。 模块[37]还包括定位成光学询问混合物的光学激发和检测组件[46,48]。 激发组件[46]包括多个光源[100]和一组用于在多个激发波长范围内用激发光束顺序地照射混合物中的标记分析物的滤光器。 检测组件[48]包括多个检测器[102]和第二组滤波器，用于在多个发射波长范围内检测从腔室[10]发射的光。 因此，光学组件[46,48]提供用于检测混合物中的多个不同目标分析物的多通道系统。

    Container for holding cells or viruses for disruption
    8.
    发明申请
    Container for holding cells or viruses for disruption 有权
    用于控制细胞或病毒的容器用于中断

    公开(公告)号：US20020187547A1

    公开(公告)日：2002-12-12

    申请号：US10208976

    申请日：2002-07-30

    Applicant: Cepheid

    Inventor： Michael T. Taylor ,  Phillip Belgrader ,  Farzad Pourahmadi ,  William A. McMillan ,  Ronald Chang ,  Douglas B. Dority

    IPC: C12M001/33

    CPC classification number: B01L3/502 ,  B01L3/50825 ,  B01L7/52 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/14 ,  B01L2400/0439 ,  B01L2400/0622 ,  B01L2400/0644 ,  C12M47/06

    Abstract: A container for holding cells or viruses for disruption comprises a chamber defined by two spaced apart, opposing major walls and side walls connecting the major walls to each other. At least one of the major walls has an external surface to which the transducer may be coupled and is sufficiently flexible to flex in response to vibratory motion of the transducer. The container also has at least one port for introducing the cells or viruses into the chamber. In some embodiments, the chamber contains beads for aiding the disruption of the cells or viruses.

    Abstract translation: 用于保持细胞或病毒用于破坏的容器包括由两个间隔开的相对的主壁和连接主壁彼此连接的侧壁限定的室。 主壁中的至少一个具有外部表面，换能器可以连接到该外表面，并且响应于换能器的振动运动而具有足够的柔性以弯曲。 容器还具有用于将细胞或病毒引入腔室中的至少一个端口。 在一些实施方案中，室包含用于帮助细胞或病毒破坏的珠。

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