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29 条记录 (耗时 0.034 秒)

    Remodelable Prosthetic Valve
    1.
    发明申请
    Remodelable Prosthetic Valve 有权
    可重塑假肢瓣膜

    公开(公告)号：US20090138078A1

    公开(公告)日：2009-05-28

    申请号：US12273284

    申请日：2008-11-18

    申请人： Ram H. Paul, JR. ,  Sean D. Chambers ,  Chad E. Johnson

    发明人： Ram H. Paul, JR. ,  Sean D. Chambers ,  Chad E. Johnson

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2230/0026 ,  A61F2230/0095 ,  A61F2250/0031

    摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.

    摘要翻译： 提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医​​疗装置的方法和使用医疗装置的治疗方法。 医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料 液体接触可重塑材料。 医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。

    Remodelable prosthetic valve
    2.
    发明授权
    Remodelable prosthetic valve 有权
    可重塑假体瓣膜

    公开(公告)号：US07846199B2

    公开(公告)日：2010-12-07

    申请号：US12273284

    申请日：2008-11-18

    申请人： Ram H. Paul, Jr. ,  Sean D. Chambers ,  Chad E. Johnson

    发明人： Ram H. Paul, Jr. ,  Sean D. Chambers ,  Chad E. Johnson

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2230/0026 ,  A61F2230/0095 ,  A61F2250/0031

    摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.

    摘要翻译： 提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医​​疗装置的方法和使用医疗装置的治疗方法。 医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料 液体接触可重塑材料。 医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。

    Methods For Producing ECM-Based Biomaterials
    3.
    发明申请
    Methods For Producing ECM-Based Biomaterials 有权
    生产基于ECM的生物材料的方法

    公开(公告)号：US20110150998A1

    公开(公告)日：2011-06-23

    申请号：US12644607

    申请日：2009-12-22

    申请人： Laura-Lee Farrell ,  Chad E. Johnson

    发明人： Laura-Lee Farrell ,  Chad E. Johnson

    IPC分类号： A61K9/14 ,  B29C41/04 ,  A61P17/02

    CPC分类号： A61K9/0087 ,  A61K38/39 ,  A61L27/3633 ,  A61L31/005 ,  B29C39/08 ,  B29C67/20

    摘要： A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume.

    摘要翻译： 用于形成细胞外基质材料（ECM）材料的方法包括提供至少一种含有ECM颗粒的ECM组合物，其中ECM颗粒的能力通过流体介质（包括至少一个扩展的ECM颗粒群体）迁移。 ECM组合物在流体介质中组合以形成可流动的ECM组合物。 可流动的ECM组合物在模具中经受足够的离心力足以根据它们的物理特性的差异分布ECM颗粒。 将ECM组合物干燥以形成具有从较不密集区域延伸至更致密区域的密度梯度的干燥的ECM材料。 干燥的ECM材料可以形成为在水性流体环境中可膨胀至少100体积的多孔，基本上无细胞的ECM材料。

    Devices and methods for treating fistulae and other bodily openings and passageways
    7.
    发明授权
    Devices and methods for treating fistulae and other bodily openings and passageways 有权
    用于治疗瘘管和其他身体开口和通道的装置和方法

    公开(公告)号：US09474514B2

    公开(公告)日：2016-10-25

    申请号：US13247156

    申请日：2011-09-28

    申请人： Charles W. Agnew ,  Mark Duncan ,  Chad E. Johnson

    发明人： Charles W. Agnew ,  Mark Duncan ,  Chad E. Johnson

    IPC分类号： A61B17/08 ,  A61B17/00 ,  A61B17/12

    CPC分类号： A61B17/0057 ,  A61B17/12099 ,  A61B17/12159 ,  A61B17/12181 ,  A61B17/1219 ,  A61B2017/00004 ,  A61B2017/00579 ,  A61B2017/00601 ,  A61B2017/00628 ,  A61B2017/00641 ,  A61B2017/0065 ,  A61B2017/00884

    摘要： Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.

    摘要翻译： 本发明的一些方面涉及用于治疗瘘管和身体其它通道和开口的独特产品和方法。 在一些优选形式中，本发明的构造将包括结合有多个片状或片状片段的细长移植体。 在一些布置中，多个片状或片状片段将沿着插塞体的长度沿大致纵向的方向堆叠，并且可选地，片段将被接收在一个或多个细长元件上。 这种细长的元件可以采取各种形式，包括缝合线，丝线，细丝或其他相对细长的细长构件，尽管在某些形式中，细长元件将是或包括一些较高的结构，例如可生物降解的或不可生物降解的 可生物降解的三维体。

    TISSUE AUGMENTATION DEVICES AND METHODS
    10.
    发明申请
    TISSUE AUGMENTATION DEVICES AND METHODS 有权
    组织补充装置及方法

    公开(公告)号：US20110046576A1

    公开(公告)日：2011-02-24

    申请号：US12939636

    申请日：2010-11-04

    申请人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    发明人： Umesh H. Patel ,  F. Joseph Obermiller ,  Bhavin Shah ,  Chad E. Johnson

    IPC分类号： A61M5/00

    CPC分类号： A61F2/0059

    摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.

    摘要翻译： 公开了组织增加装置，以及制造和使用它们的方法。 在某些实施例中，组织增强装置包括细长的组织穿透构件和一定量的可重塑材料，其中细长构件的至少一部分被插管，并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形，其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中，可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。