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公开(公告)号：US06685694B2
公开(公告)日：2004-02-03
申请号：US09859886
申请日：2001-05-16
申请人： Charles D. Finch , Paul F. Marad , John Wang , James M. Brugger
发明人： Charles D. Finch , Paul F. Marad , John Wang , James M. Brugger
IPC分类号： A61M3100
CPC分类号： A61L29/14 , A61L2/18 , A61L29/16 , A61L2300/404 , A61L2300/42 , A61L2300/45 , A61M25/00 , A61M2025/0019 , A61M2025/0056
摘要： Implanted catheters are locked with a solution comprising a lower alcohol, typically ethanol, propanol, or butanol, in a range from 1% to 99% by volume, and an additive in a range from 1% to 99% by volume, the additive comprising an anti-microbial, typically taurolidine or triclosan, or an anti-coagulant, typically riboflavin, sodium citrate, ethylene diamine tetraacetic acid, or citric acid. The use of an alcohol and additive solution can effectively reduce fouling of the catheter, particularly clotting and thrombus in intravascular catheters, as well as eradicate existing infections and/or reduce the risk of potential infections. Existing infections and/or potential infections can be further reduced by employing a catheter body which permits an anti-microbial solution to penetrate into the catheter body and preferably through the catheter into tissue surrounding the implanted catheter.
摘要翻译： 植入的导管用包含1体积％至99体积％范围内的低级醇（通常为乙醇，丙醇或丁醇）和1体积％至99体积％的添加剂的溶液锁定，所述添加剂包含 抗菌剂，通常为taurolidine或三氯生，或抗凝血剂，通常为核黄素，柠檬酸钠，乙二胺四乙酸或柠檬酸。 使用酒精和添加剂溶液可以有效地减少导管的结垢，特别是血管内导管中的凝血和血栓，以及消除现有感染和/或降低潜在感染的风险。 可以通过使用允许抗微生物溶液渗入导管体并且优选地通过导管进入植入的导管周围的组织的导管体来进一步减少现有的感染和/或潜在的感染。
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公开(公告)号：US06679870B1
公开(公告)日：2004-01-20
申请号：US09611421
申请日：2000-07-07
IPC分类号： A61M3100
CPC分类号： A61M25/00 , A61L2/18 , A61L29/14 , A61L29/16 , A61L2300/404 , A61L2300/42 , A61L2300/45 , A61M2025/0019 , A61M2025/0056
摘要： Implanted catheters are locked with a solution comprising a lower alcohol, typically ethanol, propanol, or butanol, most preferably isopropanol, and an additive, the additive comprising an anti-microbial, typically taurolidine or triclosan, or an anti-coagulant, typically riboflavin, sodium citrate, ethylene diamine tetraacetic acid, or citric acid. The use of an alcohol and additive solution can effectively reduce fouling of the catheter, particularly clotting and thrombus in intravascular catheters, as well as reduce the risk of infection. The risk of infection can be further reduced by employing a catheter body which is sufficiently porous to permit the anti-microbial solution of a lower alcohol and another anti-microbial or anti-coagulant compound to penetrate into the catheter body and preferably through the catheter into tissue surrounding the implanted catheter.
摘要翻译： 植入的导管用包含低级醇（通常为乙醇，丙醇或丁醇），最优选异丙醇和添加剂的溶液锁定，所述添加剂包含抗微生物剂，通常为taurolidine或三氯生，或抗凝血剂，通常为核黄素， 柠檬酸钠，乙二胺四乙酸或柠檬酸。 使用酒精和添加剂溶液可有效减少导管的结垢，特别是血管内导管中的凝血和血栓，以及降低感染的风险。 可以通过使用足够多孔的导管体来进一步降低感染的风险，该导管体允许低级醇和其它抗微生物剂或抗凝血剂化合物的抗微生物溶液渗入导管体内，优选通过导管进入 围绕植入导管的组织。
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公开(公告)号：US06258079B1
公开(公告)日：2001-07-10
申请号：US09333828
申请日：1999-06-15
申请人： Jeffrey H. Burbank , James M. Brugger , Charles D. Finch , Gerald Beathard , George W. Buffaloe
发明人： Jeffrey H. Burbank , James M. Brugger , Charles D. Finch , Gerald Beathard , George W. Buffaloe
IPC分类号： A61M3100
CPC分类号： A61M1/3653 , A61M1/3659 , A61M5/158 , A61M25/0023 , A61M39/0208 , A61M2005/1581 , A61M2205/195
摘要： A body lumen access system comprises a distal access cannula and a proximal access cannula. The distal access cannula is attached to or within the body lumen and the proximal access cannula is attached to an implantable port or is transcutaneously positioned and attached to a luer or other external connector. The distal and proximal access cannulas are usually implanted separately, cut to length, and attached at a subcutaneous junction location. Preferably, the proximal access cannula has a larger lumen diameter than that of the distal access cannula in order to reduce flow resistance within the cannula system. In some cases the distal and proximal access cannulas may be formed integrally. Replacement of a proximal portion or distal end may be performed by accessing the cannula, removing either the proximal portion or distal end, and reattaching a replacement portion of the cannula.
摘要翻译： 体腔通道系统包括远端进入插管和近端通路套管。 远端进入插管附接到体腔内或体腔内，并且近侧进入插管附接到可植入端口，或经皮定位并附接到鲁尔或其它外部连接器。 远端和近端通道插管通常单独植入，切割长度，并连接在皮下接合处。 优选地，近侧通路插管具有比远侧进入插管更大的内腔直径，以便减小套管系统内的流动阻力。 在一些情况下，远端和近侧通路插管可以一体形成。 近端部分或远端的替换可以通过进入插管，移除近端部分或远端以及重新附接插管的置换部分来执行。
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公开(公告)号：US06299610B1
公开(公告)日：2001-10-09
申请号：US09003772
申请日：1998-01-07
IPC分类号： A61M3100
CPC分类号： A61M39/0208 , A61M39/16 , A61M2039/0226
摘要： Implantable ports and other devices are disinfected by the injection of an anti-microbial agent into a tissue pocket surrounding the device. In a first embodiment, the anti-microbial agent is injected through an aperture in the device to flush internal regions of the device before infusing the tissue pocket. In other embodiments, the anti-microbial agent is injected directly to a target site on the exterior of the device. Implantable devices may include special, usually hardened, target regions for receiving the sharpened end of a needle used to inject the anti-microbial agent.
摘要翻译： 通过将抗微生物剂注入装置周围的组织袋中，可植入端口和其它装置被消毒。 在第一实施方案中，抗微生物剂通过装置中的孔注入，以在灌注组织袋之前冲洗装置的内部区域。 在其它实施方案中，将抗微生物剂直接注射到装置外部的靶位点。 可植入装置可以包括用于接收用于注射抗微生物剂的针的尖端的特殊的，通常硬化的靶区域。
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5.发明授权Methods and apparatus for inhibiting infection of subcutaneously implanted devices 失效用于抑制皮下植入装置感染的方法和装置公开(公告)号：US06299609B1
公开(公告)日：2001-10-09
申请号：US09333827
申请日：1999-06-15
IPC分类号： A61M3100
CPC分类号： A61M39/0208 , A61M25/0017 , A61M39/16 , A61M2005/1403 , A61M2039/0226 , A61M2209/04
摘要： Implantable ports and other devices are cleansed by the injection of a washing solution into a region in the device or in a tissue pocket surrounding the device. In a first embodiment, the washing solution is injected through an aperture in the device to flush internal regions of the device before infusing the tissue pocket and flushing outwardly through a tissue tract leading to the device. In other embodiments, the washing solution is injected directly to a target site on the exterior of the device. Implantable devices may include special, usually hardened, target regions for receiving the sharpened end of a needle used to inject the washing solution. Kits will include devices, syringes, access devices, and instructions for cleansing according to the methods of the present invention.
摘要翻译： 可植入端口和其它装置通过将洗涤溶液注入装置中的区域或围绕该装置的组织袋中来清洁。 在第一实施例中，洗涤溶液通过装置中的孔注入，以在注入组织袋之前冲洗装置的内部区域并向外冲洗通过通向该装置的组织通道。 在其他实施例中，将洗涤溶液直接注入到装置外部的目标部位。 可植入装置可以包括用于接收用于注射洗涤溶液的针的尖端的特殊的，通常硬化的目标区域。 试剂盒将包括根据本发明的方法的装置，注射器，进入装置和用于清洁的说明书。
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公开(公告)号：US06482197B2
公开(公告)日：2002-11-19
申请号：US09932455
申请日：2001-08-16
IPC分类号： A61M3100
CPC分类号： A61M39/0208 , A61M25/0017 , A61M39/16 , A61M2005/1403 , A61M2039/0226 , A61M2209/04
摘要： Implantable ports and other devices are cleansed by the injection of a washing solution into a region in the device or in a tissue pocket surrounding the device. In a first embodiment, the washing solution is injected through an aperture in the device to flush internal regions of the device before infusing the tissue pocket and flushing outwardly through a tissue tract leading to the device. In other embodiments, the washing solution is injected directly to a target site on the exterior of the device. Implantable devices may include special, usually hardened, target regions for receiving the sharpened end of a needle used to inject the washing solution. Kits will include devices, syringes, access devices, and instructions for cleansing according to the methods of the present invention.
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公开(公告)号：US5931829A
公开(公告)日：1999-08-03
申请号：US856641
申请日：1997-05-15
申请人： Jeffrey H. Burbank , James M. Brugger , Charles D. Finch , Gerald Beathard , George W. Buffaloe
发明人： Jeffrey H. Burbank , James M. Brugger , Charles D. Finch , Gerald Beathard , George W. Buffaloe
CPC分类号： A61M1/3653 , A61M39/0208 , A61M5/158 , A61M2005/1581 , A61M2205/195 , A61M25/0023
摘要： A body lumen access system comprises a distal access cannula and a proximal access cannula. The distal access cannula is attached to or within the body lumen and the proximal access cannula is attached to an implantable port or is transcutaneously positioned and attached to a luer or other external connector. The distal and proximal access cannulas are usually implanted separately, cut to length, and attached at a subcutaneous junction location. Preferably, the proximal access cannula has a larger lumen diameter than that of the distal access cannula in order to reduce flow resistance within the cannula system. In some cases the distal and proximal access cannulas may be formed integrally.
摘要翻译： 体腔通道系统包括远端进入插管和近端通路套管。 远端进入插管附接到体腔内或体腔内，并且近侧进入插管附接到可植入端口或经皮定位并附接到鲁尔或其它外部连接器。 远端和近端通道插管通常单独植入，切割长度，并连接在皮下接合处。 优选地，近侧通路插管具有比远侧进入插管更大的内腔直径，以便减小套管系统内的流动阻力。 在一些情况下，远端和近侧通路插管可以一体形成。
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公开(公告)号：US06238369B1
公开(公告)日：2001-05-29
申请号：US09333728
申请日：1999-06-15
申请人： Jeffrey H. Burbank , James M. Brugger , Charles D. Finch , Gerald Beathard , George W. Buffaloe
发明人： Jeffrey H. Burbank , James M. Brugger , Charles D. Finch , Gerald Beathard , George W. Buffaloe
IPC分类号： A61M3100
CPC分类号： A61M1/3653 , A61M1/3659 , A61M5/158 , A61M25/0023 , A61M39/0208 , A61M2005/1581 , A61M2205/195
摘要： A body lumen access system comprises a distal access cannula and a proximal access cannula. The distal access cannula is attached to or within the body lumen and the proximal access cannula is attached to an implantable port or is transcutaneously positioned and attached to a luer or other external connector. The distal and proximal access cannulas are usually implanted separately, cut to length, and attached at a subcutaneous junction location. Preferably, the proximal access cannula has a larger lumen diameter than that of the distal access cannula in order to reduce flow resistance within the cannula system. In some cases the distal and proximal access cannulas may be formed integrally.
摘要翻译： 体腔通道系统包括远端进入插管和近端通路套管。 远端进入插管附接到体腔内或体腔内，并且近侧进入插管附接到可植入端口或经皮定位并附接到鲁尔或其它外部连接器。 远端和近端通道插管通常单独植入，切割长度，并连接在皮下接合处。 优选地，近侧通路插管具有比远侧进入插管更大的内腔直径，以便减小套管系统内的流动阻力。 在一些情况下，远端和近侧通路插管可以一体形成。
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公开(公告)号：US06638478B1
公开(公告)日：2003-10-28
申请号：US09513911
申请日：2000-02-25
IPC分类号： A61M3700
CPC分类号： A61M1/342 , A61M1/1639 , A61M1/34 , A61M1/3403 , A61M1/3441 , A61M1/3444 , A61M1/3448 , A61M1/3458 , A61M1/361 , A61M1/3612 , A61M1/3626 , A61M1/3639 , A61M1/3646 , A61M1/367 , A61M39/0208 , A61M2205/126 , A61M2205/128 , A61M2205/15 , A61M2205/3331 , A61M2205/3334 , A61M2205/35 , A61M2205/3553 , A61M2205/3569 , A61M2205/505 , A61M2205/60 , A61M2205/6018 , A61M2205/6072
摘要： Systems and methods balance fluid in a fluid processing procedure during which an outgoing fluid is removed from an individual and an ingoing fluid is supplied to the individual. The systems and methods supply a volume of the outgoing fluid and a volume of the ingoing fluid into a volumetric chamber. The systems and methods discharge a volume of the outgoing fluid and a volume of the ingoing fluid from the volumetric chamber. The systems and methods synchronizes the supply and discharge of fluid to affect a concurrent discharge of the outgoing fluid and ingoing fluid from the volumetric chamber in volumetric balance with a concurrent supply of outgoing fluid and ingoing fluid into the volumetric chamber. The volumetric chamber can include at least one chamber including an interior wall dividing the chamber into a first compartment and a second compartment. The first compartment retains a volume of outgoing fluid. The second compartment retains a volume of ingoing fluid. The interior wall responds to differential fluid pressure to discharge the ingoing fluid from the second compartment as the outgoing fluid is conveyed into the first compartment, and vice versa.
摘要翻译： 系统和方法在流体处理过程中平衡流体，在该过程期间将流出的流体从个体中移出并且进入流体被供给到个体。 系统和方法将输出流体的体积和进入流体的体积提供到容积室中。 系统和方法从体积腔排出一定体积的输出流体和一定体积的流入流体。 系统和方法使流体的供应和排出同步，以同时排出流出的流体并以体积平衡从体积室输入流体，同时供给流出的流体和进入流体的容积室。 容积室可以包括至少一个室，其包括将室分成第一室和第二室的内壁。 第一个隔间保留一定量的输出流体。 第二隔间保留一定量的进入流体。 当输出流体被输送到第一隔室中时，内壁响应不同的流体压力以排出来自第二隔室的进入流体，反之亦然。
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公开(公告)号：US06592564B2
公开(公告)日：2003-07-15
申请号：US09359842
申请日：1999-07-23
申请人： Charles D. Finch , John H. Wang
发明人： Charles D. Finch , John H. Wang
IPC分类号： A61M2500
CPC分类号： A61M25/00 , A61L29/14 , A61L29/16 , A61L2300/216 , A61L2300/404 , A61M2025/0019 , A61M2025/0056
摘要： Implanted catheters are locked with a solution comprising a lower alcohol, typically ethanol, propanol, or butanol, most preferably isopropanol. The use of an alcohol can both reduce fouling of the catheter, particularly clotting and thrombus in intravascular catheters, as well as reducing the risk of infection. The risk of infection can be further reduced by employing a catheter body which is sufficiently porous to permit the lower alcohol or other anti-microbial solution to penetrate into the catheter body and preferably through the catheter into tissue surrounding the implanted catheter.
摘要翻译： 植入的导管用包含低级醇（通常为乙醇，丙醇或丁醇），最优选异丙醇的溶液锁定。 使用酒精可以减少导管的结垢，特别是血管内导管中的凝血和血栓，以及降低感染的风险。 可以通过使用足够多孔的导管主体来进一步降低感染的风险，所述导管主体允许低级醇或其它抗微生物溶液渗透到导管体中，优选地通过导管进入围绕植入的导管的组织中。
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