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公开(公告)号：US07511048B2
公开(公告)日：2009-03-31
申请号：US11666362
申请日：2005-10-26
申请人： Chengzhi Zhang , Roger Smith , Gan Wang , Sharad Verma , Qingming Zhu
发明人： Chengzhi Zhang , Roger Smith , Gan Wang , Sharad Verma , Qingming Zhu
IPC分类号： C07D239/00 , C07D471/00 , C07D471/04 , C07D471/22 , C07D487/00 , C07D487/04 , C07D491/00
CPC分类号： C07D495/14
摘要： The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
摘要翻译： 本发明涉及式（I）的新型嘧啶并噻吩并唑，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途。
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公开(公告)号：US20070299066A1
公开(公告)日：2007-12-27
申请号：US11666362
申请日：2005-10-26
申请人： Chengzhi Zhang , Roger Smith , Gan Wang , Sharad Verma , Qingming Zhu
发明人： Chengzhi Zhang , Roger Smith , Gan Wang , Sharad Verma , Qingming Zhu
IPC分类号： A61K31/381 , A61K31/5377 , A61P35/00 , C07D239/28 , C07D413/14
CPC分类号： C07D495/14
摘要： The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
摘要翻译： 本发明涉及式（I）的新型嘧啶并噻吩并唑，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途。
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公开(公告)号：US20110053928A1
公开(公告)日：2011-03-03
申请号：US12938883
申请日：2010-11-03
申请人： Chengzhi Zhang , Roger Smith , Gan Wang , Sharad Verma , Qingming Zhu
发明人： Chengzhi Zhang , Roger Smith , Gan Wang , Sharad Verma , Qingming Zhu
IPC分类号： A61K31/5355 , A61K31/519 , A61K31/496 , A61P35/00
CPC分类号： C07D495/14
摘要： The invention relates to novel pyrimidothienoindazoles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
摘要翻译： 本发明涉及式（I）的新型嘧啶并噻吩并唑，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途。
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4.发明申请Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的新型双环脲衍生物公开(公告)号：US20050038031A1
公开(公告)日：2005-02-17
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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5.发明授权Bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的双环脲衍生物公开(公告)号：US08076488B2
公开(公告)日：2011-12-13
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： C07D213/62 , C07D401/00 , C07D417/00
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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公开(公告)号：US20090186887A1
公开(公告)日：2009-07-23
申请号：US12414183
申请日：2009-03-30
申请人： Chengzhi Zhang , Roger A. Smith , Gan Wang , Sharad K. Verma , Qingming Zhu
发明人： Chengzhi Zhang , Roger A. Smith , Gan Wang , Sharad K. Verma , Qingming Zhu
IPC分类号： A61K31/5377 , C07D495/14 , A61K31/519 , A61P35/00
CPC分类号： C07D495/14
摘要： The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
摘要翻译： 本发明涉及式（I）的新型嘧啶并噻吩并唑，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途。
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7.发明申请Preparation and Use of Aryl Alkyl Acid Derivatives for the Treatment of Obesity 审中-公开芳基烷基酸衍生物用于治疗肥胖症的制备和应用公开(公告)号：US20090215780A1
公开(公告)日：2009-08-27
申请号：US11918836
申请日：2006-04-18
申请人： Roger Smith , Derek Lowe , Philip Coish , Ann-Marie Campbell , Gan Wang , Manoj Patel , Gerogiy Bondar
发明人： Roger Smith , Derek Lowe , Philip Coish , Ann-Marie Campbell , Gan Wang , Manoj Patel , Gerogiy Bondar
IPC分类号： A61K31/5375 , C07C229/40 , A61K31/192 , A61K31/4418 , C07D213/75 , C07D295/195 , A61P3/04
CPC分类号： C07D209/24 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C235/40 , C07C235/56 , C07C275/42 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/06 , C07D209/08 , C07D209/42 , C07D209/44 , C07D211/16 , C07D213/56 , C07D213/75 , C07D215/08 , C07D235/06 , C07D239/16 , C07D261/10 , C07D265/30 , C07D295/205 , C07D307/14 , C07D307/30 , C07D307/52 , C07D307/85 , C07D309/04 , C07D309/08 , C07D333/24 , C07D333/62 , C07D333/68 , C07D335/02 , C07D401/04 , C07D405/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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8.发明授权Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效芳基烷基酸衍生物的制备和用途用于治疗肥胖症公开(公告)号：US07423156B2
公开(公告)日：2008-09-09
申请号：US11341197
申请日：2006-01-27
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： C07D277/42 , C07D277/62 , C07D263/34 , C07D263/58
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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9.发明申请Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效芳基烷基酸衍生物的制备和用途用于治疗肥胖症公开(公告)号：US20090270468A1
公开(公告)日：2009-10-29
申请号：US12231878
申请日：2008-09-05
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Minghao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Minghao Zhang , Lei Zhu
IPC分类号： A61K31/428 , C07D277/82 , A61K31/423 , C07D263/58 , C07D235/30 , A61K31/4184 , A61P3/04
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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10.发明申请PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开用于治疗糖尿病的芳基酸衍生物的制备和使用公开(公告)号：US20090197795A1
公开(公告)日：2009-08-06
申请号：US12185813
申请日：2008-08-04
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/428 , A61K38/28 , A61P3/10 , A61K38/22 , A61P3/04 , A61K31/423 , A61K31/426 , A61K31/4184 , C07D277/82 , C07D235/30 , C07D277/38 , C07D263/58
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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