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    Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5
    6.
    发明申请
    Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5 审中-公开
    代谢型谷氨酸受体-5的二芳基取代的吡唑调节剂

    公开(公告)号：US20060194807A1

    公开(公告)日：2006-08-31

    申请号：US10551709

    申请日：2004-03-30

    申请人： Nicholas Cosford ,  Brian Eastman ,  Dehua Huang ,  Nicholas Smith ,  Lida Tehrani ,  Essa Hu

    发明人： Nicholas Cosford ,  Brian Eastman ,  Dehua Huang ,  Nicholas Smith ,  Lida Tehrani ,  Essa Hu

    IPC分类号： A61K31/506 ,  A61K31/498 ,  A61K31/4709 ,  A61K31/4439 ,  C07D403/14

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

    摘要： Novel pyrazole compounds such as compounds of the formula (I): (where A, A1, A2, B, R11, W, X, Y and Z are as defined herein) in which the pyrazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, obesity, drug addiction, drug abuse, drug withdrawal and other diseases.

    摘要翻译： 新的吡唑化合物，例如式（I）的化合物：其中A，A 1，A 2，B，R 11，W ，X，Y和Z如本文所定义），其中吡唑直接被取代，或通过桥取代，其中i）杂芳基部分含有与杂芳基的连接点相邻的N，和ii）另一个杂芳基或芳基环 ，其中至少一个环被另一个环取代，是用于治疗精神病和情绪障碍的mGluR5调节剂，例如精神分裂症，焦虑症，抑郁症，恐慌症和双相情感障碍，以及在 治疗疼痛，帕金森病，认知功能障碍，癫痫，昼夜节律紊乱，肥胖，药物成瘾，药物滥用，戒毒等疾病。

    4-Ring imidazole derivatives as modulators of metabotropic glutamate receptor-5
    9.
    发明申请
    4-Ring imidazole derivatives as modulators of metabotropic glutamate receptor-5 审中-公开
    4-环咪唑衍生物作为代谢型谷氨酸受体-5的调节剂

    公开(公告)号：US20060217420A1

    公开(公告)日：2006-09-28

    申请号：US10552107

    申请日：2004-03-30

    申请人： Nicholas Cosford ,  Dehua Huang ,  Nicholas Smith ,  Essa Hsinyi Hu

    发明人： Nicholas Cosford ,  Dehua Huang ,  Nicholas Smith ,  Essa Hsinyi Hu

    IPC分类号： A61K31/444 ,  C07D403/14

    CPC分类号： C07D233/64 ,  C07D401/04 ,  C07D401/14 ,  C07D471/04

    摘要： Imidazole compounds of Formula (I): (where A, B, R11, R12, W, X, Y and Z are as defined herein) wherein the imidazole is substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, which are MgluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders—such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases, and pharmaceutical compositions and methods of treating these diseases.

    摘要翻译： 式（I）的咪唑化合物（其中A，B，R 11，R 12，W，X，Y和Z如本文所定义），其中咪唑是 直接或桥接，其中i）杂芳基部分，其含有与杂芳基的连接点相邻的N，和ii）另一杂芳基或芳基环，其中至少一个环进一步被另一个环取代， 用于治疗精神病和情绪障碍（例如精神分裂症，焦虑症，抑郁症，双相性精神障碍和恐慌）以及治疗疼痛，帕金森病，认知功能障碍，癫痫，昼夜节律和睡眠的MgluR5调节剂 疾病 - 如转移工作诱导的睡眠障碍和时滞，药物成瘾，药物滥用，药物戒断，肥胖症等疾病，以及治疗这些疾病的药物组合物和方法。