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12 条记录 (耗时 0.023 秒)

    Method for using HIP/PAP polypeptide composition for liver regeneration and prevention of liver failure
    6.
    发明授权
    Method for using HIP/PAP polypeptide composition for liver regeneration and prevention of liver failure 有权
    使用HIP / PAP多肽组合物进行肝脏再生和预防肝功能衰竭的方法

    公开(公告)号：US08329661B2

    公开(公告)日：2012-12-11

    申请号：US13032521

    申请日：2011-02-22

    申请人： Laurence Christa ,  Christian Brechot ,  Marie-Thérèse Simon-Gage-Soufflot ,  Alain Pauloin ,  J. Guilherme Tralhao

    发明人： Laurence Christa ,  Christian Brechot ,  Marie-Thérèse Simon-Gage-Soufflot ,  Alain Pauloin ,  J. Guilherme Tralhao

    IPC分类号： A61P1/16 ,  A61K38/17 ,  C07K14/47

    CPC分类号： A61K38/1709

    摘要： This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytcs, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No 1, in combination with at least one physiologically acceptable excipient.

    摘要翻译： 本发明基于实验发现，HIP / PAP在原代培养中对肝细胞具有促有丝分裂和抗细胞凋亡作用。 此外，HIP / PAP是一种有丝分裂和抗凋亡的分子，用于肝细胞，体内，肝衰竭和肝脏再生。 本发明还基于实验发现，HIP / PAP施用对哺乳动物没有不利影响。 本发明涉及一种用于刺激体内肝脏再生的药物组合物，包括在慢性/急性肝衰竭后，包括有效量的多肽，其包含与由氨基酸序列开始的氨基酸序列具有90％氨基酸同一性的氨基酸序列 氨基酸残基（36）并结束于序列SEQ ID No.1的氨基酸残基（175），与至少一种生理上可接受的赋形剂组合。

    Nucleotide sequence encoding human cyclin A
    8.
    发明授权
    Nucleotide sequence encoding human cyclin A 失效
    编码人细胞周期蛋白A的核苷酸序列

    公开(公告)号：US6103887A

    公开(公告)日：2000-08-15

    申请号：US210889

    申请日：1998-12-15

    申请人： Christian Brechot ,  Jian Wang ,  Xavier Chenivesse ,  Berthold Henglein ,  Frederique Zindy

    发明人： Christian Brechot ,  Jian Wang ,  Xavier Chenivesse ,  Berthold Henglein ,  Frederique Zindy

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12N15/12 ,  C07H21/04 ,  C12N15/11 ,  C12N15/63

    CPC分类号： C12N15/113 ,  C07K14/4738 ,  C07K16/18 ,  A61K38/00 ,  C12N2310/3513

    摘要： The invention is directed generally to a DNA sequence coding for human cyclin A and in particular to antibodies, or antisera including such antibodies, which bind to human cyclin A as encoded by the sequence of SEQ ID NO: 1 and which are useful in detecting cellular proliferation. The antibodies of the invention can be polyclonal or monoclonal, and are preferably generated by injection of purified human cyclin A into an animal host. The invention is particularly advantageous because it has been discovered that the gene encoding for human cyclin A is a site for integration of the hepatitis B virus associated with hepatocellular carcinoma, and by detecting human cyclin A through the use of the antibodies of the invention, one can detect and diagnose cell proliferation. Through the use of the present invention, cell proliferation and tumorigenesis can thus be detected at early stages, and such conditions can then be treated or inhibited by the use of anti-sense human cyclin A DNA.

    摘要翻译： 本发明一般涉及编码人类细胞周期蛋白A的DNA序列，特别是编码抗体或包含此类抗体的抗血清，其结合如SEQ ID NO：1的序列编码的人细胞周期蛋白A并且可用于检测细胞 增殖。 本发明的抗体可以是多克隆的或单克隆的，并且优选通过将纯化的人细胞周期蛋白A注射到动物宿主中来产生。 本发明是特别有利的，因为已经发现编码人细胞周期蛋白A的基因是与肝细胞癌相关的乙型肝炎病毒整合的位点，并且通过使用本发明的抗体检测人细胞周期蛋白A 可以检测和诊断细胞增殖。 通过使用本发明，因此可以在早期阶段检测细胞增殖和肿瘤发生，然后可以通过使用反义人细胞周期蛋白A DNA来治疗或抑制这些病症。

    Process for the detection of cell proliferation by detecting human cyclin A
    9.
    发明授权
    Process for the detection of cell proliferation by detecting human cyclin A 失效
    通过检测人细胞周期蛋白A检测细胞增殖的过程

    公开(公告)号：US5849508A

    公开(公告)日：1998-12-15

    申请号：US460895

    申请日：1995-06-05

    申请人： Christian Brechot ,  Jian Wang ,  Xavier Chenivesse ,  Berthold Henglein ,  Frederique Zindy

    发明人： Christian Brechot ,  Jian Wang ,  Xavier Chenivesse ,  Berthold Henglein ,  Frederique Zindy

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12N15/12 ,  G01N33/574 ,  G01N33/53 ,  G01N33/567

    CPC分类号： C12N15/113 ,  C07K14/4738 ,  C07K16/18 ,  A61K38/00 ,  C12N2310/3513

    摘要： The invention is directed generally to a DNA sequence coding for human cyclin A and in particular to antibodies, or antisera including such antibodies, which bind to human cyclin A as encoded by the sequence of SEQ ID NO: 1 and which are useful in detecting cellular proliferation. The antibodies of the invention can be polyclonal or monoclonal, and are preferably generated by injection of purified human cyclin A into an animal host. The invention is particularly advantageous because it has been discovered that the gene encoding for human cyclin A is a site for integration of the hepatitis B virus associated with hepatocellular carcinoma, and by detecting human cyclin A through the use of the antibodies of the invention, one can detect and diagnose cell proliferation. Through the use of the present invention, cell proliferation and tumorigenesis can thus be detected at early stages, and such conditions can then be treated or inhibited by the use of anti-sense human cyclin A DNA.

    摘要翻译： 本发明一般涉及编码人类细胞周期蛋白A的DNA序列，特别是编码抗体或包含此类抗体的抗血清，其结合如SEQ ID NO：1的序列编码的人细胞周期蛋白A，并且其可用于检测细胞 增殖。 本发明的抗体可以是多克隆的或单克隆的，并且优选通过将纯化的人细胞周期蛋白A注射到动物宿主中来产生。 本发明是特别有利的，因为已经发现编码人细胞周期蛋白A的基因是与肝细胞癌相关的乙型肝炎病毒整合的位点，并且通过使用本发明的抗体检测人细胞周期蛋白A 可以检测和诊断细胞增殖。 通过使用本发明，因此可以在早期阶段检测细胞增殖和肿瘤发生，然后可以通过使用反义人细胞周期蛋白A DNA来治疗或抑制这些病症。

    HIP/PAP Polypeptide Composition for Use in Liver Regeneration and for the Prevention of Liver Failure
    10.
    发明申请
    HIP/PAP Polypeptide Composition for Use in Liver Regeneration and for the Prevention of Liver Failure 有权
    HIP / PAP用于肝脏再生和预防肝衰竭的多肽组合物

    公开(公告)号：US20110144036A1

    公开(公告)日：2011-06-16

    申请号：US13032521

    申请日：2011-02-22

    申请人： Laurence Christa ,  Christian Brechot ,  Marie-Thérèse Simon-Gage-Soufflot ,  Alain Pauloin ,  J. Guilherme Tralhao

    发明人： Laurence Christa ,  Christian Brechot ,  Marie-Thérèse Simon-Gage-Soufflot ,  Alain Pauloin ,  J. Guilherme Tralhao

    IPC分类号： A61K38/17 ,  A61P1/16

    CPC分类号： A61K38/1709

    摘要： This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytcs, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No 1, in combination with at least one physiologically acceptable excipient.

    摘要翻译： 本发明基于实验发现，HIP / PAP在原代培养中对肝细胞具有促有丝分裂和抗细胞凋亡作用。 此外，HIP / PAP是一种有丝分裂和抗凋亡的分子，用于肝细胞，体内，肝衰竭和肝脏再生。 本发明还基于实验发现，HIP / PAP施用对哺乳动物没有不利影响。 本发明涉及一种用于刺激体内肝脏再生的药物组合物，包括在慢性/急性肝衰竭后，包括有效量的多肽，其包含与由氨基酸序列开始的氨基酸序列具有90％氨基酸同一性的氨基酸序列 氨基酸残基（36）并结束于序列SEQ ID No.1的氨基酸残基（175），与至少一种生理上可接受的赋形剂组合。