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    Compositions and methods for the diagnosis and treatment of immune disorders
    3.
    发明申请
    Compositions and methods for the diagnosis and treatment of immune disorders 失效
    用于诊断和治疗免疫疾病的组合物和方法

    公开(公告)号：US20070059303A1

    公开(公告)日：2007-03-15

    申请号：US11599098

    申请日：2006-11-14

    申请人： Gillian Kingsbury ,  Kevin Leiby

    发明人： Gillian Kingsbury ,  Kevin Leiby

    IPC分类号： A61K39/395 ,  A61K38/19 ,  A61K31/7072 ,  A61K31/704 ,  C07H21/04 ,  C12P21/06 ,  A61K31/66 ,  A61K31/522

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/52 ,  C07K2317/21 ,  C07K2317/74 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

    摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders. In this regard, the invention provides methods for the identification and therapeutic use of compounds for treatments of immune disorders, especially TH cell subpopulation-related disorders and including TH2 and TH2-like disorders (i.e., disorders associated with a TH2 or TH2-like mediated immune response) such as atopic conditions (e.g., allergy and asthma). Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders and for monitoring the efficacy of compounds used in clinical trials.

    摘要翻译： 本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关疾病的方法和组合物。 特别地，本发明描述了本领域已知的基因，或者作为ST2，T1和Fit-1，并且在本文中称为103基因。 本文公开的103基因在TH2细胞中不差异表达，而不在TH1细胞中。 此外，103基因产物在本文中被证明是体外和体内TH2和TH2样免疫应答的重要调节剂。 因此，103基因，其基因产物和与其结合的抗体可以在诊断上用作治疗性干预的目标，用于治疗各种免疫疾病。 在这方面，本发明提供了用于鉴定和治疗用于治疗免疫疾病，特别是TH细胞亚群相关病症并包括TH2和TH2样病症（即与TH2或TH2样介导的相关的病症）的化合物的方法 免疫反应），如特应性病症（如过敏和哮喘）。 另外，提供了用于TH细胞亚群相关疾病的诊断评价和预后的方法，用于鉴定表现出这种病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，并监测所用化合物的功效 在临床试验中。

    81588 methods and compositions of human proteins and uses thereof
    4.
    发明申请
    81588 methods and compositions of human proteins and uses thereof 审中-公开
    81588人蛋白质的方法和组合物及其用途

    公开(公告)号：US20060040306A1

    公开(公告)日：2006-02-23

    申请号：US11206587

    申请日：2005-08-18

    申请人： Kevin Leiby ,  Rosana Kapeller-Libermann ,  Maria Glucksmann

    发明人： Kevin Leiby ,  Rosana Kapeller-Libermann ,  Maria Glucksmann

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C12N9/6489 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/78 ,  C12Y304/24057 ,  C12Y305/04004

    摘要： The invention provides isolated nucleic acids molecules, designated 38650, 28472, 5495, 65507, 81588 or 14354 nucleic acid molecules, which encode novel adenosine deaminase, glycoprotease, or seven transmembrane receptor family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38650, 28472, 5495, 65507, 81588 or 14354 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38650, 28472, 5495, 65507, 81588 or 14354 gene has been introduced or disrupted. The invention still further provides isolated 38650, 28472, 5495, 65507, 81588 or 14354 proteins, fusion proteins, antigenic peptides and anti-38650, 28472, 5495, 65507, 81588 or 14354 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为38650,28472,5495,65507,81588或14354核酸分子，其编码新的腺苷脱氨酶，糖蛋白酶或七个跨膜受体家族成员。 本发明还提供反义核酸分子，含有38650,28472,5495,65507,81588或14354核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中38650,28472， 5495,65507,81588或14354基因被引入或破坏。 本发明还进一步提供分离的38650,28472,5495,65507,81588或14354蛋白，融合蛋白，抗原肽和抗-38650,28472,5495,65507,81588或14354抗体。 还提供了利用本发明组合物的诊断方法。

    Novel human membrane-associated protein and cell surface protein family members
    6.
    发明申请
    Novel human membrane-associated protein and cell surface protein family members 审中-公开
    新型人膜相关蛋白和细胞表面蛋白家族成员

    公开(公告)号：US20050019838A1

    公开(公告)日：2005-01-27

    申请号：US10860779

    申请日：2004-06-03

    申请人： Rachel Meyers ,  Maria Glucksmann ,  Rory Curtis ,  Rosana Kapeller-Libermann ,  Rajasekhar Bandaru ,  Kevin Leiby

    发明人： Rachel Meyers ,  Maria Glucksmann ,  Rory Curtis ,  Rosana Kapeller-Libermann ,  Rajasekhar Bandaru ,  Kevin Leiby

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/53 ,  C07H21/04 ,  G01N33/567

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/705 ,  C07K14/70596 ,  C07K2319/00

    摘要： The invention provides isolated nucleic acids molecules, designated 16051a, 16051b, 58199, 57805, 56739, 39362, and 23228 nucleic acid molecules, which encode novel human membrane-associated protein family members, and human cell surface protein family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 gene has been introduced or disrupted. The invention still further provides isolated 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 proteins, fusion proteins, antigenic peptides and anti-16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供了编码新的人膜相关蛋白家族成员和人类细胞表面蛋白家族成员的分离的核酸分子，命名为16051a，16051b，58199,57805,56739,39362和23228核酸分子。 本发明还提供反义核酸分子，含有16051a，16051b，58199,57805,56739,39362或23228核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中16051a ，16051b，58199,57805,56739,39362或23228基因被引入或破坏。 本发明还进一步提供分离的16051a，16051b，58199,57805,56739,39362或23228蛋白，融合蛋白，抗原肽和抗-16051a，16051b，58199,57805,56739,39362或23228抗体。 还提供了利用本发明组合物的诊断方法。