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    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
    3.
    发明申请
    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 失效
    编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因

    公开(公告)号：US20070048771A1

    公开(公告)日：2007-03-01

    申请号：US11491318

    申请日：2006-07-21

    申请人： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

    发明人： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/47

    摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

    Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
    4.
    发明申请
    Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof 审中-公开
    Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和整合素α亚基蛋白和核酸分子及其用途

    公开(公告)号：US20060122373A1

    公开(公告)日：2006-06-08

    申请号：US11175714

    申请日：2005-07-05

    申请人： Sean McCarthy ,  David Gearing ,  Douglas Holtzman ,  Yang Pan ,  Samantha Busfield ,  Thomas Barnes ,  Charles Mackay ,  Jose Lora

    发明人： Sean McCarthy ,  David Gearing ,  Douglas Holtzman ,  Yang Pan ,  Samantha Busfield ,  Thomas Barnes ,  Charles Mackay ,  Jose Lora

    IPC分类号： C07K14/705 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Antibodies having diagnostic, preventive, therapeutic, and other uses
    5.
    发明申请
    Antibodies having diagnostic, preventive, therapeutic, and other uses 失效
    具有诊断，预防，治疗和其他用途的抗体

    公开(公告)号：US20070053904A1

    公开(公告)日：2007-03-08

    申请号：US11499835

    申请日：2006-08-04

    申请人： Susan Kirst ,  Douglas Holtzman ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes

    发明人： Susan Kirst ,  Douglas Holtzman ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes

    IPC分类号： G01N33/567 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K16/28 ,  G01N33/5058

    摘要： The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质和核酸的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses
    6.
    发明申请
    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses 审中-公开

    公开(公告)号：US20060211848A1

    公开(公告)日：2006-09-21

    申请号：US11441587

    申请日：2006-05-26

    申请人： Douglas Holtzman ,  Andrew Goodearl ,  Sean McCarthy

    发明人： Douglas Holtzman ,  Andrew Goodearl ,  Sean McCarthy

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12N9/6489 ,  A01K2217/05 ,  A01K2227/105 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70578 ,  C07K2319/00

    摘要： The invention relates to Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83 polypeptides, nucleic acid molecules encoding Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83, and uses thereof. The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    Novel molecules of the FTHMA-070-related protein family and the T85-related protein family and uses thereof
    7.
    发明申请
    Novel molecules of the FTHMA-070-related protein family and the T85-related protein family and uses thereof 审中-公开
    FTHMA-070相关蛋白家族和T85相关蛋白家族的新分子及其用途

    公开(公告)号：US20050032172A1

    公开(公告)日：2005-02-10

    申请号：US10895676

    申请日：2004-07-21

    申请人： Sean McCarthy ,  Douglas Holtzman

    发明人： Sean McCarthy ,  Douglas Holtzman

    IPC分类号： G01N33/53 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  C07K14/52 ,  C07H21/04

    CPC分类号： C07K14/70503 ,  C07K14/70578

    摘要： Novel FTHMA-070 and T85 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FTHMA-070 and T85 proteins, the invention further provides isolated FTHMA-070 and T85 fusion proteins, antigenic peptides and anti-FTHMA-070 and anti-T85 antibodies. The invention also provides FTHMA-070 and T85 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FTHMA-070 gene or T85 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的FTHMA-070和T85多肽，蛋白质和核酸分子。 除了分离的全长FTHMA-070和T85蛋白之外，本发明还提供了分离的FTHMA-070和T85融合蛋白，抗原肽和抗FTHMA-070和抗T85抗体。 本发明还提供了FTHMA-070和T85核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中FTHMA-070基因或T85的非人转基因动物 基因已被引入或破坏。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses
    8.
    发明申请
    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses 审中-公开
    编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新型基因

    公开(公告)号：US20050019810A1

    公开(公告)日：2005-01-27

    申请号：US10900926

    申请日：2004-07-28

    申请人： Douglas Holtzman ,  Andrew Goodearl ,  Sean McCarthy

    发明人： Douglas Holtzman ,  Andrew Goodearl ,  Sean McCarthy

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/715 ,  C12Q1/68 ,  G01N33/68 ,  C07H21/04

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K14/7151 ,  C07K2319/00 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6872

    摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。