专利检索 ap:("Christopher J. Hess" OR "Jerome R. Morgan" OR "William B. Weisenburgh" OR "James W. Voegele" OR "Mark S. Ortiz" OR "Michael J. Stokes" OR "Carl Shurtleff" OR "Frederick E. Shelton" OR "Jeffrey S. Swayze") AND inv:"Michael J. Stokes" 第 1 页

1.

发明授权
Surgical staples having compressible or crushable members for securing tissue therein and stapling instruments for deploying the same 有权
标题翻译：具有用于固定其中的组织的可压缩或可压碎构件的手术订书钉，以及用于展开其的装订工具

公开(公告)号：US07794475B2

公开(公告)日：2010-09-14

申请号：US11541123

申请日：2006-09-29

申请人： Christopher J. Hess , Jerome R. Morgan , William B. Weisenburgh, II , James W. Voegele , Mark S Ortiz , Michael J. Stokes , Carl Shurtleff , Frederick E. Shelton, IV , Jeffrey S. Swayze

发明人： Christopher J. Hess , Jerome R. Morgan , William B. Weisenburgh, II , James W. Voegele , Mark S Ortiz , Michael J. Stokes , Carl Shurtleff , Frederick E. Shelton, IV , Jeffrey S. Swayze

IPC分类号： A61B17/08

CPC分类号： A61B17/068 , A61B17/0644 , A61B17/07207 , A61B17/07292 , A61B17/105 , A61B17/11 , A61B17/1155 , A61B17/34 , A61B90/03 , A61B2017/00004 , A61B2017/00128 , A61B2017/00539 , A61B2017/00831 , A61B2017/00862 , A61B2017/0641 , A61B2017/07228 , A61B2017/07242 , A61B2017/0725 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2932 , A61B2017/2943 , A61B2017/320052 , A61B2018/00666 , A61B2090/032 , A61B2090/036 , A61B2090/065 , A61B2090/0811

摘要： A staple having a crown, a deformable leg extending from the crown, and a spring extending from the crown configured to compress tissue between the spring and the deformable member. Owing to the flexibility of the spring, the staple can accommodate a wide range of tissue thicknesses while still compressing the tissue captured therein. As a result, a single staple design can be used in a wide variety of surgical procedures thereby reducing the amount of staple designs that must be provided to the surgeon. In at least one embodiment, the staple includes a crushable member. This crushable member can include a plastically deformable first portion and an elastically deformable second portion. The present invention can also include, in various embodiments, a crown, a first deformable member extending from the crown, and means for compressing the tissue against the first deformable member.

摘要翻译： 具有冠部的钉，从冠部延伸的可变形腿部以及从冠部延伸的弹簧，其构造成在弹簧和可变形构件之间压缩组织。由于弹簧的灵活性，订书钉可以适应宽范围的组织厚度，同时仍然压缩其中捕获的组织。结果，单个钉设计可以用于各种各样的手术过程，从而减少必须提供给外科医生的钉设计的数量。在至少一个实施例中，订书钉包括可压碎构件。该可压碎构件可以包括可塑性变形的第一部分和可弹性变形的第二部分。在各种实施例中，本发明还可以包括冠部，从冠部延伸的第一可变形构件以及用于将组织压靠在第一可变形构件上的装置。

2.

发明申请
SURGICAL STAPLES HAVING COMPRESSIBLE OR CRUSHABLE MEMBERS FOR SECURING TISSUE THEREIN AND STAPLING INSTRUMENTS FOR DEPLOYING THE SAME 审中-公开
标题翻译：具有用于保护组织的可压缩或可破坏的成员的外科手术带和用于分配组织的装订仪

公开(公告)号：US20110060363A1

公开(公告)日：2011-03-10

申请号：US12880414

申请日：2010-09-13

申请人： Christopher J. Hess , Jerome R. Morgan , William B. Weisenburgh, II , James W. Voegele , Mark S. Ortiz , Michael J. Stokes , Carl Shurtleff , Frederick E. Shelton, IV , Jeffrey S. Swayze

发明人： Christopher J. Hess , Jerome R. Morgan , William B. Weisenburgh, II , James W. Voegele , Mark S. Ortiz , Michael J. Stokes , Carl Shurtleff , Frederick E. Shelton, IV , Jeffrey S. Swayze

IPC分类号： A61B17/08

摘要： A staple having a crown, a deformable leg extending from the crown, and a spring extending from the crown configured to compress tissue between the spring and the deformable member. Owing to the flexibility of the spring, the staple can accommodate a wide range of tissue thicknesses while still compressing the tissue captured therein. As a result, a single staple design can be used in a wide variety of surgical procedures thereby reducing the amount of staple designs that must be provided to the surgeon. In at least one embodiment, the staple includes a crushable member. This crushable member can include a plastically deformable first portion and an elastically deformable second portion. The present invention can also include, in various embodiments, a crown, a first deformable member extending from the crown, and means for compressing the tissue against the first deformable member.

摘要翻译： 具有冠部的钉，从冠部延伸的可变形腿部以及从冠部延伸的弹簧，其构造成在弹簧和可变形构件之间压缩组织。由于弹簧的灵活性，订书钉可以适应宽范围的组织厚度，同时仍然压缩其中捕获的组织。结果，单个钉设计可以用于各种各样的手术过程，从而减少必须提供给外科医生的钉设计的数量。在至少一个实施例中，订书钉包括可压碎构件。该可压碎构件可以包括可塑性变形的第一部分和可弹性变形的第二部分。在各种实施例中，本发明还可以包括冠部，从冠部延伸的第一可变形构件以及用于将组织压靠在第一可变形构件上的装置。

3.

发明申请
Surgical staples having compressible or crushable members for securing tissue therein and stapling instruments for deploying the same 有权
标题翻译：具有用于固定其中的组织的可压缩或可压碎构件的手术订书钉，以及用于展开其的装订工具

公开(公告)号：US20080082124A1

公开(公告)日：2008-04-03

申请号：US11541123

申请日：2006-09-29

申请人： Christopher J. Hess , Jerome R. Morgan , William B. Weisenburgh , James W. Voegele , Mark S. Ortiz , Michael J. Stokes , Carl Shurtleff , Frederick E. Shelton , Jeffrey S. Swayze

发明人： Christopher J. Hess , Jerome R. Morgan , William B. Weisenburgh , James W. Voegele , Mark S. Ortiz , Michael J. Stokes , Carl Shurtleff , Frederick E. Shelton , Jeffrey S. Swayze

IPC分类号： A61B17/08

CPC分类号： A61B17/068 , A61B17/0644 , A61B17/07207 , A61B17/07292 , A61B17/105 , A61B17/11 , A61B17/1155 , A61B17/34 , A61B90/03 , A61B2017/00004 , A61B2017/00128 , A61B2017/00539 , A61B2017/00831 , A61B2017/00862 , A61B2017/0641 , A61B2017/07228 , A61B2017/07242 , A61B2017/0725 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2932 , A61B2017/2943 , A61B2017/320052 , A61B2018/00666 , A61B2090/032 , A61B2090/036 , A61B2090/065 , A61B2090/0811

摘要： A staple having a crown, a deformable leg extending from the crown, and a spring extending from the crown configured to compress tissue between the spring and the deformable member. Owing to the flexibility of the spring, the staple can accommodate a wide range of tissue thicknesses while still compressing the tissue captured therein. As a result, a single staple design can be used in a wide variety of surgical procedures thereby reducing the amount of staple designs that must be provided to the surgeon. In at least one embodiment, the staple includes a crushable member. This crushable member can include a plastically deformable first portion and an elastically deformable second portion. The present invention can also include, in various embodiments, a crown, a first deformable member extending from the crown, and means for compressing the tissue against the first deformable member.

摘要翻译： 具有冠部的钉，从冠部延伸的可变形腿部以及从冠部延伸的弹簧，其构造成在弹簧和可变形构件之间压缩组织。由于弹簧的灵活性，订书钉可以适应宽范围的组织厚度，同时仍然压缩其中捕获的组织。结果，单个钉设计可以用于各种各样的手术过程，从而减少必须提供给外科医生的钉设计的数量。在至少一个实施例中，订书钉包括可压碎构件。该可压碎构件可以包括可塑性变形的第一部分和可弹性变形的第二部分。在各种实施例中，本发明还可以包括冠部，从冠部延伸的第一可变形构件以及用于将组织压靠在第一可变形构件上的装置。

4.

发明申请
INTESTINAL BRAKE INDUCING INTRALUMINAL THERAPEUTIC SUBSTANCE ELUTING DEVICES AND METHODS 有权
标题翻译： INTESTINAL BRAKE INDING IN INTRALUMINAL THERAPEUTIC THEAPEUTIC TYSTURE ELDTING ELTERTING DEVICES AND METHODS

公开(公告)号：US20110295180A1

公开(公告)日：2011-12-01

申请号：US13105029

申请日：2011-05-11

申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski

发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski

IPC分类号： A61F2/04

CPC分类号： A61F5/0076 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F5/0079 , A61F2002/045

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

5.

发明申请
Systems and Methods For Regulating Metabolic Hormone Producing Tissue 审中-公开
标题翻译：用于调节代谢激素生产组织的系统和方法

公开(公告)号：US20110295337A1

公开(公告)日：2011-12-01

申请号：US13105262

申请日：2011-05-11

申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Edward G. Chekan , Sean P. Conlon , Michael S. Cropper , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Kevin L. Houser , John V. Hunt , Gary L. Long , Prasanna Malaviya , Amy L. Marcotte , Rudolph H. Nobis , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , David N. Plescia , Galen C. Robertson , Randy J. Seeley , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , James A. Woodard, JR. , David C. Yates , Andrew M. Zwolinski

发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Edward G. Chekan , Sean P. Conlon , Michael S. Cropper , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Kevin L. Houser , John V. Hunt , Gary L. Long , Prasanna Malaviya , Amy L. Marcotte , Rudolph H. Nobis , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , David N. Plescia , Galen C. Robertson , Randy J. Seeley , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , James A. Woodard, JR. , David C. Yates , Andrew M. Zwolinski

IPC分类号： A61N1/36

CPC分类号： A61N1/00 , A61F5/0026 , A61N1/0509 , A61N1/327 , A61N1/36007

摘要： A method for regulating hormone production comprises placing at least one electrode in a gastrointestinal tract of a patient and recording an electrical signal during a preselected event produced by the gastrointestinal tract. The method further involves the steps of storing the electrical signal, and playing back the electrical signal by activating the electrode during the absence of the preselected event.

摘要翻译： 用于调节激素产生的方法包括将至少一个电极放置在患者的胃肠道中，并在由胃肠道产生的预选事件期间记录电信号。该方法还包括存储电信号的步骤，以及在没有预选事件期间激活电极来播放电信号。

6.

发明申请
Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods 有权
标题翻译：肠制动诱导腔内治疗物质洗脱装置及方法

公开(公告)号：US20110295185A1

公开(公告)日：2011-12-01

申请号：US13104313

申请日：2011-05-10

申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski

发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski

IPC分类号： A61M37/00 , A61K31/20 , A61M5/00 , A61F2/00 , A61M5/168 , A61N1/36

CPC分类号： A61M31/002 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F2002/045 , A61K9/0065 , A61M5/14276 , A61M39/0208 , A61M2210/106 , A61M2210/1064 , A61N1/0509 , A61N1/36007 , A61N1/37205

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质从植入物到胃肠道。

7.

发明申请
Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods 审中-公开
标题翻译：肠制动诱导腔内治疗物质洗脱装置及方法

公开(公告)号：US20110295178A1

公开(公告)日：2011-12-01

申请号：US13104321

申请日：2011-05-10

申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Gregory J. Bakos , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Suzanne Thompson , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski

发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Gregory J. Bakos , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Suzanne Thompson , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski

IPC分类号： A61M5/00

CPC分类号： A61F5/0079 , A61K9/0065 , A61M5/14276 , A61M31/002 , A61M39/0208 , A61M2210/106 , A61M2210/1064

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices may be accomplished via stabilized implantable systems and ingestible pills. In one aspect, a method of inducing satiety includes implanting an implant within a lumen of a gastrointestinal tract and retaining a portion of chyme that flows by the implant within a body of the implant. The method further involves re-releasing the retained chyme from the implant into the gastrointestinal tract at a predetermined rate slower than a rate caused by natural peristalsis.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置可以通过稳定的可植入系统和可摄取的药丸来实现。一方面，一种诱导饱腹感的方法包括将植入物植入胃肠道的内腔中，并且将植入物流动的部分保持在植入物的体内。该方法还包括以比由天然蠕动引起的速率慢的预定速率将留置的食糜从植入物再释放到胃肠道中。

8.

发明授权
Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods 有权
标题翻译：肠内制动诱导管腔内治疗物质洗脱装置及方法

公开(公告)号：US08876761B2

公开(公告)日：2014-11-04

申请号：US13104313

申请日：2011-05-10

申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, Jr. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, Jr. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski

发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, Jr. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, Jr. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski

IPC分类号： A61M31/00 , A61K9/00 , A61M5/142 , A61F5/00 , A61N1/05 , A61M39/02 , A61F2/04 , A61N1/36 , A61N1/372

CPC分类号： A61M31/002 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F2002/045 , A61K9/0065 , A61M5/14276 , A61M39/0208 , A61M2210/106 , A61M2210/1064 , A61N1/0509 , A61N1/36007 , A61N1/37205

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质从植入物到胃肠道。