PROCESS FOR THE PREPARATION OF HYDROGENATED NITRILE RUBBER
    7.
    发明申请
    PROCESS FOR THE PREPARATION OF HYDROGENATED NITRILE RUBBER 有权
    制备氢化橡胶的方法

    公开(公告)号:US20120329954A1

    公开(公告)日:2012-12-27

    申请号:US13391633

    申请日:2010-08-27

    IPC分类号: C08F8/04

    摘要: The present invention relates to a process for the production of hydrogenated nitrile rubber polymers having lower molecular weights and narrower molecular weight distributions than those known in the art, wherein the process is carried out in the presence of hydrogen and optionally at least one co-olefin. The present invention further relates to the use of specific metal compounds in a process for the production of a hydrogenated nitrile rubber by simultaneous hydrogenation and metathesis of a nitrile rubber.

    摘要翻译: 本发明涉及生产具有比本领域已知的分子量低和分子量分布窄的氢化丁腈橡胶聚合物的方法,其中该方法在氢气和任选的至少一种共聚烯烃存在下进行 。 本发明还涉及通过丁腈橡胶的同时氢化和复分解在生产氢化丁腈橡胶的方法中使用特定的金属化合物。

    Treatment of Cancer by Inhibition of HSP27
    8.
    发明申请
    Treatment of Cancer by Inhibition of HSP27 审中-公开
    通过抑制HSP27治疗癌症

    公开(公告)号:US20090281166A1

    公开(公告)日:2009-11-12

    申请号:US12423359

    申请日:2009-04-14

    摘要: A cancer is evaluated for selection of appropriate therapy by evaluating a sample of cancerous tissue to determine an expression of level of phosphatase and tensin homologue deleted from chromosome 10 (PTEN); and in the case where the expression level of functional PTEN is below a threshold level, identifying the cancer as susceptible to an active agent that inhibits the expression of heat shock protein 27 (hsp27). The evaluation may be included as part of a method of treatment, in which an hsp27 inhibitor is selected as a therapeutic agent when the PTEN level is below the threshold.

    摘要翻译: 通过评估癌组织样品来评估癌症的选择以确定从10号染色体(PTEN)缺失的磷酸酶和张力蛋白同源物的水平的表达; 并且在功能性PTEN的表达水平低于阈值水平的情况下,鉴定对抑制热休克蛋白27(hsp27)表达的活性剂敏感的癌症。 评价可以作为治疗方法的一部分被包括,其中当PTEN水平低于阈值时,选择hsp27抑制剂作为治疗剂。