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1.发明申请PROCESS FOR REMOVING IRON-RESIDUES, RHODIUM- AND RUTHENIUM-CONTAINING CATALYST RESIDUES FROM OPTIONALLY HYDROGENATED NITRILE RUBBER 审中-公开从选择性加氢硝酸橡胶中除去含有硫酸盐和含铑催化剂残留物的方法公开(公告)号：US20090227444A1
公开(公告)日：2009-09-10
申请号：US12336691
申请日：2008-12-17
CPC分类号： C08C2/04 , C08C2019/09 , C08L15/005
摘要： A process is provided for the removal of iron-residues, rhodium- and/or ruthenium-containing catalyst residues from a solution of optionally hydrogenated nitrile rubber containing such iron-residues, rhodium- and/or ruthenium-containing residues by contacting such solution with a specific functionalized ion exchange resin.
摘要翻译： 提供了一种从含有这些铁残基，含铑和/或钌的残留物的任选氢化的丁腈橡胶的溶液中除去含铁铑，铑和/或钌的催化剂残余物的方法， 特定的官能化离子交换树脂。
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2.发明授权Process for removing ruthenium-containing catalyst residues from optionally hydrogenated nitrile rubber 有权从任选氢化丁腈橡胶中除去含钌催化剂残留物的方法公开(公告)号：US07846995B2
公开(公告)日：2010-12-07
申请号：US12336626
申请日：2008-12-17
IPC分类号： C08F6/16
CPC分类号： C08C2/04 , C08C2019/09 , C08L15/005
摘要： Novel optionally hydrogenated nitrile rubbers distinguised by a very low ruthenium content are provided as well as a process for the removal of ruthenium-containing catalyst residues from a solution of optionally hydrogenated nitrile rubber by using specific functionalized ion-exchange resins.
摘要翻译： 提供了由非常低的钌含量区分的新的任选氢化的丁腈橡胶，以及通过使用特定的官能化离子交换树脂从任选氢化的丁腈橡胶的溶液中除去含钌催化剂残余物的方法。
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公开(公告)号：US08895671B2
公开(公告)日：2014-11-25
申请号：US12487679
申请日：2009-06-19
申请人： Christopher Ong , Stephen Pask , Sharon Guo , Yong Zhang , Lan Lu
发明人： Christopher Ong , Stephen Pask , Sharon Guo , Yong Zhang , Lan Lu
IPC分类号： C08L13/00 , C08K3/04 , C08L9/02 , C08K7/24 , C08J3/24 , C08K7/06 , C08J3/20 , C08K3/06 , C08K5/14 , C01B31/02
CPC分类号： C08K7/06 , C01B32/05 , C08J3/20 , C08J3/24 , C08K3/04 , C08K3/041 , C08K3/06 , C08K3/22 , C08K5/14 , C08K7/24 , C08K2003/2217 , C08K2201/003 , C08L9/02 , C08L13/00 , Y02E10/549 , C08L15/005
摘要： The present invention provides a vulcanizable composition containing a specific hydrogenated nitrile rubber, at least one cross-linking agent and carbon nanotubes, a process for preparing such composition and the use thereof for preparing vulcanizates. Said vulcanizates exhibit excellent heat performance, oil resistance and mechanical strength.
摘要翻译： 本发明提供含有特定氢化丁腈橡胶，至少一种交联剂和碳纳米管的可硫化组合物，该组合物的制备方法及其制备硫化橡胶的用途。 所述硫化胶具有优异的热性能，耐油性和机械强度。
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公开(公告)号：US20130261246A1
公开(公告)日：2013-10-03
申请号：US12487679
申请日：2009-06-19
申请人： Christopher Ong , Stephen Pask , Sharon Guo , Yong Zhang , Lan Lu
发明人： Christopher Ong , Stephen Pask , Sharon Guo , Yong Zhang , Lan Lu
IPC分类号： C08K7/06
CPC分类号： C08K7/06 , C01B32/05 , C08J3/20 , C08J3/24 , C08K3/04 , C08K3/041 , C08K3/06 , C08K3/22 , C08K5/14 , C08K7/24 , C08K2003/2217 , C08K2201/003 , C08L9/02 , C08L13/00 , Y02E10/549 , C08L15/005
摘要： The present invention provides a vulcanizable composition containing a specific hydrogenated nitrile rubber, at least one cross-linking agent and carbon nanotubes, a process for preparing such composition and the use thereof for preparing vulcanizates. Said vulcanizates exhibit excellent heat performance, oil resistance and mechanical strength.
摘要翻译： 本发明提供含有特定氢化丁腈橡胶，至少一种交联剂和碳纳米管的可硫化组合物，该组合物的制备方法及其用于制备硫化橡胶的用途。 所述硫化胶具有优异的热性能，耐油性和机械强度。
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公开(公告)号：US20070287806A1
公开(公告)日：2007-12-13
申请号：US11807502
申请日：2007-05-29
申请人： Christopher Ong , Stephen Pask , Sharon Guo , Franz Mersmann
发明人： Christopher Ong , Stephen Pask , Sharon Guo , Franz Mersmann
IPC分类号： C08F20/44
CPC分类号： C08C19/02 , B01J19/02 , B01J19/1887 , B01J2219/00085 , B01J2219/00162 , B01J2219/00164 , B01J2219/00189 , B01J2219/0236 , C08L15/005
摘要： The present invention provides a novel process for preparing hydrogenated nitrile rubbers comprising subjecting nitrile rubbers in a spinning disk reactor to hydrogenation. The present process is less demanding with regard to its reaction conditions, like e.g. the hydrogen pressure to be applied, compared to known processes and significantly reduces the cost of the hydrogenation process and in particular the equipment cost.
摘要翻译： 本发明提供了制备氢化丁腈橡胶的新方法，其包括将旋转盘反应器中的丁腈橡胶进行氢化。 本方法对其反应条件的要求较低，例如 与已知方法相比，要施加的氢气压力显着降低氢化过程的成本，特别是设备成本。
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公开(公告)号：US08765994B2
公开(公告)日：2014-07-01
申请号：US13213901
申请日：2011-08-19
申请人： Raymond Andersen , David E. Williams , Alice Mui , Christopher Ong , Gerald Krystal , Lu Yang
发明人： Raymond Andersen , David E. Williams , Alice Mui , Christopher Ong , Gerald Krystal , Lu Yang
IPC分类号： A61K31/21 , A61K31/075 , C07C69/76 , C07C43/21 , C07J63/00
CPC分类号： C07J63/00
摘要： The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.
摘要翻译： 本发明包括使用作为SHIP1活性调节剂的托泊醇，相关化合物及其药物组合物。 本发明还提供能够调节SHIP1活性的新型萜烯化合物及其合成方法。
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公开(公告)号：US20120329954A1
公开(公告)日：2012-12-27
申请号：US13391633
申请日：2010-08-27
IPC分类号： C08F8/04
CPC分类号： C08C19/02 , B01J31/181 , B01J31/1815 , B01J31/2265 , B01J31/2291 , B01J2231/641 , B01J2531/821 , B01J2531/825 , C08C19/08 , C08C2019/09 , C08L15/005
摘要： The present invention relates to a process for the production of hydrogenated nitrile rubber polymers having lower molecular weights and narrower molecular weight distributions than those known in the art, wherein the process is carried out in the presence of hydrogen and optionally at least one co-olefin. The present invention further relates to the use of specific metal compounds in a process for the production of a hydrogenated nitrile rubber by simultaneous hydrogenation and metathesis of a nitrile rubber.
摘要翻译： 本发明涉及生产具有比本领域已知的分子量低和分子量分布窄的氢化丁腈橡胶聚合物的方法，其中该方法在氢气和任选的至少一种共聚烯烃存在下进行 。 本发明还涉及通过丁腈橡胶的同时氢化和复分解在生产氢化丁腈橡胶的方法中使用特定的金属化合物。
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公开(公告)号：US20090281166A1
公开(公告)日：2009-11-12
申请号：US12423359
申请日：2009-04-14
申请人： Martin Gleave , Christopher Ong , Norihiro Hayashi
发明人： Martin Gleave , Christopher Ong , Norihiro Hayashi
IPC分类号： A61K31/7088 , C12Q1/68 , C12Q1/42 , A61K31/519 , A61K31/435 , A61K31/4355 , A61K31/05
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/158 , G01N33/57484
摘要： A cancer is evaluated for selection of appropriate therapy by evaluating a sample of cancerous tissue to determine an expression of level of phosphatase and tensin homologue deleted from chromosome 10 (PTEN); and in the case where the expression level of functional PTEN is below a threshold level, identifying the cancer as susceptible to an active agent that inhibits the expression of heat shock protein 27 (hsp27). The evaluation may be included as part of a method of treatment, in which an hsp27 inhibitor is selected as a therapeutic agent when the PTEN level is below the threshold.
摘要翻译： 通过评估癌组织样品来评估癌症的选择以确定从10号染色体（PTEN）缺失的磷酸酶和张力蛋白同源物的水平的表达; 并且在功能性PTEN的表达水平低于阈值水平的情况下，鉴定对抑制热休克蛋白27（hsp27）表达的活性剂敏感的癌症。 评价可以作为治疗方法的一部分被包括，其中当PTEN水平低于阈值时，选择hsp27抑制剂作为治疗剂。
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公开(公告)号：US09079979B2
公开(公告)日：2015-07-14
申请号：US13391633
申请日：2010-08-27
CPC分类号： C08C19/02 , B01J31/181 , B01J31/1815 , B01J31/2265 , B01J31/2291 , B01J2231/641 , B01J2531/821 , B01J2531/825 , C08C19/08 , C08C2019/09 , C08L15/005
摘要： The present invention relates to a process for the production of hydrogenated nitrile rubber polymers having lower molecular weights and narrower molecular weight distributions than those known in the art, wherein the process is carried out in the presence of hydrogen and optionally at least one co-olefin. The present invention further relates to the use of specific metal compounds in a process for the production of a hydrogenated nitrile rubber by simultaneous hydrogenation and metathesis of a nitrile rubber.
摘要翻译： 本发明涉及生产具有比本领域已知的分子量低和分子量分布窄的氢化丁腈橡胶聚合物的方法，其中该方法在氢气和任选的至少一种共聚烯烃存在下进行 。 本发明还涉及通过丁腈橡胶的同时氢化和复分解在生产氢化丁腈橡胶的方法中使用特定的金属化合物。
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公开(公告)号：US20150057450A1
公开(公告)日：2015-02-26
申请号：US14238270
申请日：2012-08-15
申请人： Julia Maria Jeschko , Douglas Stephan , Clinton Lund , Michael Sgro , Christopher Ong , Renan Cariou
发明人： Julia Maria Jeschko , Douglas Stephan , Clinton Lund , Michael Sgro , Christopher Ong , Renan Cariou
IPC分类号： C07F15/00 , C07C231/12 , C07C5/05 , B01J31/22 , C07C5/03 , C07C253/30 , C07C67/303
CPC分类号： C07F15/0046 , B01J31/2226 , B01J31/2273 , B01J31/2404 , B01J2231/645 , B01J2531/821 , B01J2540/10 , C07B2200/07 , C07C5/03 , C07C5/05 , C07C5/09 , C07C29/175 , C07C45/62 , C07C67/303 , C07C209/70 , C07C231/12 , C07C253/30 , C07C315/04 , C07C319/20 , C07C2531/22 , C07C2531/24 , C07C2601/14 , C07D213/127 , C07D233/06 , C07F17/02 , C07C69/34 , C07C321/28 , C07C255/03 , C07C211/06 , C07C233/47 , C07C317/14 , C07C49/10 , C07C47/02 , C07C31/10 , C07C9/14 , C07C13/18 , C07C15/46
摘要： The present invention provides novel Ruthenium-based transition metal complex catalysts comprising specific ligands, their preparation and their use in hydrogenation processes. Such complex catalysts are inexpensive, thermally robust, and olefin selective.
摘要翻译： 本发明提供了新型的基于钌的过渡金属络合物催化剂，其包括特定配体，其制备及其在氢化方法中的应用。 这种复合催化剂是廉价的，热稳定的和烯烃选择性的。
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