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1.发明授权Method and system for producing a moisture content map for use in moisture sorting green veneer using light transmission 有权用于生产用于使用光透射的水分分选绿色贴面的水分含量图的方法和系统公开(公告)号：US06974035B2
公开(公告)日：2005-12-13
申请号：US10418080
申请日：2003-04-18
申请人： Chunping Dai , Tony Thomas , Kevin Groves , Heng Xu
发明人： Chunping Dai , Tony Thomas , Kevin Groves , Heng Xu
CPC分类号： B07C5/3416 , B07C5/14 , G01N21/59 , G01N21/8914
摘要： Disclosed is a method and system for sorting a plurality of green wood veneer sheets into a plurality of subsets of sheets, the subsets including a “driest” subset, a “wettest” subset, and one or more “intermediate” subsets. The system has a light source for transmitting light through a sheet of veneer as it passes along a conveyor system, and a light sensor for sensing the light passing through the sheet. The pattern of light is recorded by an image acquisition and processing subsystem as an image, which is fed to an image analysis subsystem programmed to analyse the light pattern and to produce a mathematical representation of the image. An integrated moisture content value (IMCV) is set for the particular veneer sheet. Based on this value, a controller sends signals to the conveyor system to convey the particular sheet to a location storing sheets having similar IMCV values for drying.
摘要翻译： 公开了一种用于将多个绿色木材单板片材分类成多个片材子集的方法和系统，所述子集包括“最干净的”子集，“最湿”的子集以及一个或多个“中间”子集。 该系统具有一个光源，用于在沿着输送系统通过一片胶合板时传输光，以及光传感器，用于感测通过该纸张的光。 光的图案由图像采集和处理子系统记录为图像，其被馈送到图像分析子系统，该图像分析子系统被编程以分析光图案并产生图像的数学表示。 为特定的单板设置综合水分含量值（IMCV）。 基于该值，控制器向输送机系统发送信号以将特定纸张传送到存储具有相似IMCV值的纸张的位置用于干燥。
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公开(公告)号：US10221159B2
公开(公告)日：2019-03-05
申请号：US13467694
申请日：2012-05-09
申请人： Kevin Groves , Bagna Bao
发明人： Kevin Groves , Bagna Bao
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00 , C07D401/06 , C07D209/14 , C07D209/60 , C07D401/14 , C07D417/14 , A61K49/00 , G01N33/58 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , G01N21/64 , C09B23/01 , C09B23/08
摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
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公开(公告)号：US09913917B2
公开(公告)日：2018-03-13
申请号：US11645111
申请日：2006-12-22
申请人： Kevin Groves , Milind Rajopadhye
发明人： Kevin Groves , Milind Rajopadhye
CPC分类号： A61K49/1866 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/0093 , A61K49/1833 , A61K49/186 , B82Y5/00
摘要： The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.
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公开(公告)号：US20090220430A1
公开(公告)日：2009-09-03
申请号：US12355777
申请日：2009-01-17
申请人： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
发明人： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
CPC分类号： A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
摘要翻译： 提供了用于体内和体外成像的分子内骤冷成像剂家族，其包含至少一种可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是不淬灭的，并且在用适当波长的光激发时变得能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。
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公开(公告)号：US20080317676A1
公开(公告)日：2008-12-25
申请号：US12065385
申请日：2006-09-01
申请人： Milind Rajopadhye , Kevin Groves
发明人： Milind Rajopadhye , Kevin Groves
IPC分类号： C07D401/14 , C07D401/02 , C07D413/14 , A61K49/00 , A61K49/04
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0052 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086 , G01N33/533
摘要： This invention relates to new fluorescent chemical entities that are designed to attach to biocompatible molecules to form in vivo optical imaging agents.
摘要翻译： 本发明涉及被设计成附着于生物相容性分子以形成体内光学成像剂的新荧光化学实体。
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公开(公告)号：US20080226562A1
公开(公告)日：2008-09-18
申请号：US11645111
申请日：2006-12-22
申请人： Kevin Groves , Milind Rajopadhye
发明人： Kevin Groves , Milind Rajopadhye
CPC分类号： A61K49/1866 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/0093 , A61K49/1833 , A61K49/186 , B82Y5/00
摘要： The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.
摘要翻译： 本发明涉及高度荧光的金属氧化物纳米颗粒，生物分子和其它化合物可以化学连接以形成用于体外和体内应用的生物相容性，稳定的光学成像剂。 荧光金属氧化物纳米颗粒也可用于磁共振成像（MRI），从而提供多模态成像剂。
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公开(公告)号：US08815214B2
公开(公告)日：2014-08-26
申请号：US12355777
申请日：2009-01-17
申请人： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
发明人： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/00 , A61K38/04
CPC分类号： A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
摘要翻译： 提供了用于体内和体外成像的分子内骤冷成像剂家族，其包含至少一种可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是不淬灭的，并且在用适当波长的光激发时变得能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。
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公开(公告)号：US20120321563A1
公开(公告)日：2012-12-20
申请号：US13467694
申请日：2012-05-09
申请人： Kevin Groves , Bagna Bao
发明人： Kevin Groves , Bagna Bao
IPC分类号： C07D417/14 , A61K49/00 , A61K31/4439 , A61K31/506 , A61P9/00 , A61K31/433 , A61P35/00 , A61P37/00 , A61P29/00 , C07D401/14 , A61K31/444
CPC分类号： C07D401/06 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K49/0002 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D209/60 , C07D401/14 , C07D417/14 , C09B23/0008 , C09B23/0033 , C09B23/083 , C09B23/086 , G01N21/6458 , G01N33/582 , G01N2333/988 , Y02A50/411 , Y02A50/414 , Y02A50/423
摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
摘要翻译： 本发明提供靶向碳酸酐酶的试剂，其可用作显像剂或治疗剂。 这些药剂可用于成像肿瘤缺氧以及受试者中的其他生理过程。
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公开(公告)号：US07947256B2
公开(公告)日：2011-05-24
申请号：US12065385
申请日：2006-09-01
申请人： Milind Rajopadhye , Kevin Groves
发明人： Milind Rajopadhye , Kevin Groves
IPC分类号： A61K49/04
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0052 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086 , G01N33/533
摘要： This invention relates to new carbocyanine fluorophores comprising a biomolecule targeting moiety containing 1-6 aromatic moieties, wherein the targeting moiety is designed to attach to biocompatible molecules to form in vivo optical imaging agents.
摘要翻译： 本发明涉及包含含有1-6个芳族部分的生物分子靶向部分的新的碳代花青荧光团，其中靶向部分设计成附着于生物相容性分子以形成体内光学成像剂。
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10.发明授权Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels 有权生物相容性N，N-二取代磺酰胺荧光染料标记公开(公告)号：US09574085B2
公开(公告)日：2017-02-21
申请号：US12065387
申请日：2006-09-01
IPC分类号： A61K49/00 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C09B23/08 , C07D209/14 , C09B23/01 , G01N33/533 , G01N33/537 , G01N33/58
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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