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1.发明申请公开(公告)号：US20080269298A1
公开(公告)日：2008-10-30
申请号：US12113224
申请日：2008-05-01
申请人： Clarence W. Andrews , Mui Cheung , Ronda G. Davis-Ward , David Harold Drewry , Kyle Allen Emmitte , Robert Dale Hubbard , Kevin W. Kuntz , James Andrew Linn , Robert Anthony Mook , Gary Keith Smith , James Marvin Veal
发明人： Clarence W. Andrews , Mui Cheung , Ronda G. Davis-Ward , David Harold Drewry , Kyle Allen Emmitte , Robert Dale Hubbard , Kevin W. Kuntz , James Andrew Linn , Robert Anthony Mook , Gary Keith Smith , James Marvin Veal
IPC分类号： A61K31/4184 , A61P35/00 , A61K31/4439 , C07D409/14 , C07D409/04
CPC分类号： C07D491/04 , C07D409/04 , C07D409/14
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供式（I）化合物：含有该化合物的药物组合物，其制备方法及其作为药剂的用途。
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公开(公告)号：US20080058515A1
公开(公告)日：2008-03-06
申请号：US10566040
申请日：2004-07-23
IPC分类号： C07D211/32 , C07D215/00 , C07D231/56 , C07D261/04 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D471/10
CPC分类号： C07D417/12 , C04B35/632 , C07D231/56 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10
摘要： Indazolylacrylamide derivatives, which are useful as SGK-1 inhibitors are described herein. The described invention also includes methods of making such indazolylacrylamide derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate SGK-1 activity.
摘要翻译： 本文描述了可用作SGK-1抑制剂的吲唑基丙烯酰胺衍生物。 所述的发明还包括制备这种吲唑基丙烯酰胺衍生物的方法以及使用该吲唑基丙烯酰胺衍生物的方法来治疗由不适当的SGK-1活性介导的疾病。
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公开(公告)号：US07262203B2
公开(公告)日：2007-08-28
申请号：US11383229
申请日：2006-05-15
申请人： Amogh Boloor , Mui Cheung , Ronda Davis , Philip Anthony Harris , Kevin Hinkle , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
发明人： Amogh Boloor , Mui Cheung , Ronda Davis , Philip Anthony Harris , Kevin Hinkle , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
IPC分类号： C07D239/48 , C07D403/04 , A61K31/506 , A61P27/02
CPC分类号： C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要： Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号：US07858626B2
公开(公告)日：2010-12-28
申请号：US11830024
申请日：2007-07-30
申请人： Amogh Boloor , Mui Cheung , Ronda Gayle Davis-Ward , Philip Anthony Harris , Kevin Hinkle , Christopher P. Lauderman , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
发明人： Amogh Boloor , Mui Cheung , Ronda Gayle Davis-Ward , Philip Anthony Harris , Kevin Hinkle , Christopher P. Lauderman , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
IPC分类号： C07D403/04 , A61K31/53 , A61P35/00
CPC分类号： C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要： Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号：US07105530B2
公开(公告)日：2006-09-12
申请号：US10451305
申请日：2001-12-19
申请人： Amogh Boloor , Mui Cheung , Ronda Davis , Philip Anthony Harris , Kevin Hinkle , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
发明人： Amogh Boloor , Mui Cheung , Ronda Davis , Philip Anthony Harris , Kevin Hinkle , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
IPC分类号： C07D239/48 , A61K31/506 , A61P27/02
CPC分类号： C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要： Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also Includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号：US07459455B2
公开(公告)日：2008-12-02
申请号：US10503874
申请日：2003-02-07
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D239/48
摘要： Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号：US07238813B2
公开(公告)日：2007-07-03
申请号：US10433128
申请日：2001-11-28
申请人： Mui Cheung , Philip Anthony Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Marvin Veal , Yoshiaki Washio , Rob I. West
发明人： Mui Cheung , Philip Anthony Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Marvin Veal , Yoshiaki Washio , Rob I. West
IPC分类号： A61K31/4184 , C07D235/30
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D235/32 , C07D263/58 , C07D277/82 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04
摘要： Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作TIE-2和/或VEGFR2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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公开(公告)号：US20120277258A1
公开(公告)日：2012-11-01
申请号：US13545029
申请日：2012-07-10
申请人： Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Christopher P. Laudeman , Jeffrey Alan Stafford , James Marvin Veal
发明人： Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Christopher P. Laudeman , Jeffrey Alan Stafford , James Marvin Veal
IPC分类号： A61K31/506 , A61P35/00
CPC分类号： C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要： Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号：US08114885B2
公开(公告)日：2012-02-14
申请号：US11830608
申请日：2007-07-30
申请人： Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Jeffery Alan Stafford , James Marvin Veal
发明人： Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Jeffery Alan Stafford , James Marvin Veal
IPC分类号： C07D239/48 , A61K31/506 , A61P35/00
CPC分类号： C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要： Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号：US20100105712A1
公开(公告)日：2010-04-29
申请号：US12609398
申请日：2009-10-30
申请人： Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Jeffery Alan Stafford , James Marvin Veal
发明人： Amogh Boloor , Mui Cheung , Philip Anthony Harris , Kevin Hinkle , Jeffery Alan Stafford , James Marvin Veal
IPC分类号： A61K31/506 , A61P7/00 , A61P27/10 , C07D403/12
CPC分类号： C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要： Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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