公开(公告)号：US07248194B2

公开(公告)日：2007-07-24

申请号：US10558712

申请日：2004-05-25

申请人： Albertus Johannes Antonius Rutten ,  Nicolaas Johannes Hendricus Maria Van Beurden ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink

发明人： Albertus Johannes Antonius Rutten ,  Nicolaas Johannes Hendricus Maria Van Beurden ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink

IPC分类号： H03M1/00

CPC分类号： G11B20/10037 ,  G11B20/10009 ,  G11B20/1403 ,  H03L7/07 ,  H03L7/0994 ,  H04L7/0029 ,  H04L7/0334

摘要： Disclosed is a bit-detection arrangement able to convert an analog signal (AS) having an amplitude into a digital signal (DS) representing a bit sequence from which the analog signal (AS) is derived. The bit-detection arrangement has a phase detector which detect the phase difference between a quantized analog signal and a clock signal C2. The phase difference is sampled by an AD converter. The AD converter can sample at a relatively slow rate as the phase difference is a low frequency signal. The sampled phase difference is fed to a digital PLL which outputs a phase signal PHI. The phase signal and the quantized analog signal are used to recreate the digital signal (DS). The current invention is characterized in that the bit decision unit further comprises—at least one additional sample and hold unit SH2 able to sample the output signal S1, using a clock signal CSH2 and wherein the frequency of the clock signal CSH2 is equal to the frequency of clock signal CSH1 and the phase of clock signal CSH2 is substantially different from the phase of clock signal CSH1, and an output unit for outputting samples of either the sample and hold units SH1 or SH2, wherein the samples of the sample and hold unit SH1 are outputted when the phase signal PH1 indicates that the phase difference ΔP1 is in a first region and the samples of the additional sample and hold unit SH2 are outputted when the phase signal PH1 indicates that the phase difference ΔP1 is in a second region. This has the advantage that the change of bit errors occurring in the presence of phase jitter is reduced.

公开(公告)号：US20080314749A1

公开(公告)日：2008-12-25

申请号：US12159465

申请日：2006-10-25

申请人： Mark Thomas Johnson ,  Albert Hendrik Jan Immink ,  Marc Wilhelmus Gijsbert Ponjee ,  Mirielle Ann Reijme ,  Josephus Arnoldus Henricus Maria Kahlman ,  Jeroen Hans Nieuwenhuis ,  Bart Michiel De Boer

发明人： Mark Thomas Johnson ,  Albert Hendrik Jan Immink ,  Marc Wilhelmus Gijsbert Ponjee ,  Mirielle Ann Reijme ,  Josephus Arnoldus Henricus Maria Kahlman ,  Jeroen Hans Nieuwenhuis ,  Bart Michiel De Boer

IPC分类号： G01N27/26

CPC分类号： G01N33/54326 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2400/0415 ,  B01L2400/043 ,  G01N27/745 ,  G01N33/5438

摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.

摘要翻译： 本发明涉及一种微电子器件（200），特别是包括可在样品室（10）中产生磁场（B））的B / E电极（21）的磁性生物传感器。 所述装置还包括可与所述B / E电极（21）配合地在样品室（10）中产生电场（E）的E电极（23,24）。 因此，B / E电极用于两个目的。 样品室（10）中的电场（E）可特别用于泵送和/或混合流体样品或用于颗粒结合的严格性测试。

公开(公告)号：US08797028B2

公开(公告)日：2014-08-05

申请号：US12738317

申请日：2008-10-21

申请人： Coen Adrianus Johannes Verschuren ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink ,  Mischa Megens ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

发明人： Coen Adrianus Johannes Verschuren ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink ,  Mischa Megens ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

IPC分类号： G01R33/02 ,  G01N33/00 ,  G01N21/55

CPC分类号： G01N15/06 ,  G01N15/0656 ,  G01N2015/0693 ,  G01R33/1269

摘要： A sensor device and a method for the determination of the amount of target particles at a contact surface adjacent to a sample chamber include detecting, by a detector, the target particles in the sample chamber by a sensor element, and providing at least one corresponding sensor signal. An evaluation unit determines the amount of target particles in a first zone at the contracts surface and in a second zone a distance away from the contact surface based on this sensor signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions, such as wavelength and/or angle of incidence, may be used to extract information about the first and second zones. In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone.

摘要翻译： 用于确定与样品室相邻的接触表面处的目标颗粒的量的传感器装置和方法包括通过检测器通过传感器元件检测样品室中的目标颗粒，并且提供至少一个相应的传感器 信号。 评估单元基于该传感器信号确定在合同表面处的第一区域中的目标颗粒的量和距接触表面一定距离的第二区域中的目标颗粒的量。 在光学测量方法中，可以使用在诸如波长和/或入射角的不同操作条件下发生的沮丧的全内反射来提取关于第一和第二区域的信息。 在磁测量方法中，可以使用不同的磁激励场来在第一和第二区域中不同地激励磁性目标颗粒。

公开(公告)号：US20100259254A1

公开(公告)日：2010-10-14

申请号：US12738317

申请日：2008-10-21

申请人： Coen Adrianus Johannes Verschuren ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink ,  Mischa Megens ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

发明人： Coen Adrianus Johannes Verschuren ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink ,  Mischa Megens ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

IPC分类号： G01R33/02 ,  G01N33/00 ,  G01N21/55

CPC分类号： G01N15/06 ,  G01N15/0656 ,  G01N2015/0693 ,  G01R33/1269

摘要： The invention relates to a sensor device (100) and a method for the determination of the amount of target particles (1) at a contact surface (112) adjacent to a sample chamber (2). Target particles (1) in the sample chamber are detected by a sensor element (SE) and at least one corresponding sensor-signal (s, s′) is provided. An evaluation unit (EU) then determines the amount of target particles (1) in a first zone (Z1) immediately at the contracts surface (112) and a second zone (Z2) a distance (z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidence) may be used to extract information about the first and second zones (Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone (Z2). Moreover, the temporal course of a sensor-signal (s, s′) can be evaluated, particularly with respect to stochastic movements of the target particles (1).

摘要翻译： 本发明涉及一种传感器装置（100）和用于确定在与样品室（2）相邻的接触表面（112）处的目标颗粒（1）的量的方法。 通过传感器元件（SE）检测样品室中的目标颗粒（1），并提供至少一个对应的传感器信号（s，s'）。 然后，评估单元（EU）基于紧接表面（112）立即确定第一区域（Z1）中的目标颗粒（1）的数量和远离接触表面的距离（z）的第二区域（Z2），基于 这个传感器信号。 在光学测量方法中，可以使用在不同操作条件（例如波长，入射角）下发生的沮丧的全内反射来提取关于第一和第二区（Z1，Z2）的信息。 在磁测量方法中，可以使用不同的磁激励场来在第一和第二区（Z2）中不同地激励磁目标颗粒。 此外，可以评估传感器信号（s，s'）的时间过程，特别是关于目标颗粒（1）的随机运动。

公开(公告)号：US20100231213A1

公开(公告)日：2010-09-16

申请号：US12294479

申请日：2007-03-23

申请人： Jeroen Hans Nieuwenhuis ,  Theodorus Petrus Henricus Gerardus Jansen ,  Jeroen Veen ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink

发明人： Jeroen Hans Nieuwenhuis ,  Theodorus Petrus Henricus Gerardus Jansen ,  Jeroen Veen ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink

IPC分类号： G01R33/02

CPC分类号： G01R33/09 ,  B82Y25/00 ,  G01R33/007 ,  G01R33/093 ,  G01R33/12 ,  G01R33/1269

摘要： A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.

摘要翻译： 描述了用于定性或定量检测调制磁场的磁场特性的检测系统（100,150）。 调制磁场可以例如。 来自相邻的电流（Iadj）或磁性颗粒。 检测系统（100,150）包括至少一个磁阻传感器元件（102），用于提供流过磁传感器元件（102）的感测电流（Isense）的电流控制器（104）和控制装置（108） 。 控制装置（108）适于以第一频率f1导出至少一个磁阻传感器的温度相关参数。 此外，控制装置（108）还适于导出相邻电流（Iadj）或磁性颗粒的定性或定量特性，同时考虑导出的温度相关参数。 该第二频率（f1）与第一频率（f1）不同。 本发明还涉及相应的方法。

公开(公告)号：US20090066318A1

公开(公告)日：2009-03-12

申请号：US12282889

申请日：2007-03-06

申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink ,  Haris Duric ,  Adrianus Johannes Maria Van Tuijl ,  Eugenio Cantatore ,  Hendrik Johannes Bergveld

发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink ,  Haris Duric ,  Adrianus Johannes Maria Van Tuijl ,  Eugenio Cantatore ,  Hendrik Johannes Bergveld

IPC分类号： G01N27/74

CPC分类号： G01N33/54333 ,  B82Y25/00 ,  G01N27/745 ,  G01N2446/00 ,  G01R33/09 ,  G01R33/093 ,  G01R33/12 ,  G01R33/1269

摘要： The invention relates to a magnetic sensor device comprising excitation wires (11, 13) for generating a magnetic excitation field and a magnetic sensor element, particularly a GMR sensor (12), for sensing magnetic fields generated by labeling particles in reaction to the excitation field. The magnetic excitation fields are generated with non-sinusoidal forms, particularly as square-waves, such that their spectral range comprises a plurality of frequency components. Magnetic particles with different magnetic response characteristics can then be differentiated according to their reactions to the different frequency components of the excitation fields. The magnetic excitation field and the sensing current driving the GMR sensor (12) are preferably generated with the help of ring modulators (22, 24). Moreover, ring modulators (27, 29) may be used for the demodulation of the sensor signal.

摘要翻译： 本发明涉及一种包括用于产生磁场的激励线（11,13）和磁传感器元件（特别是GMR传感器）的磁传感器装置，用于感测通过与激发场反应来标记颗粒而产生的磁场 。 磁激励场以非正弦形式产生，特别是作为方波产生，使得它们的光谱范围包括多个频率分量。 然后可以根据其对激发场的不同频率分量的反应来区分具有不同磁响应特性的磁性颗粒。 驱动GMR传感器（12）的磁激励场和感测电流优选地通过环形调制器（22,24）的产生。 此外，环形调制器（27,29）可以用于解调传感器信号。

公开(公告)号：US20080218165A1

公开(公告)日：2008-09-11

申请号：US12065612

申请日：2006-09-07

申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer ,  Albert Hendrik Jan Immink ,  Jeroen Hans Nieuwenhuis

发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer ,  Albert Hendrik Jan Immink ,  Jeroen Hans Nieuwenhuis

IPC分类号： G01N27/72

CPC分类号： G01N33/54326 ,  G01N27/745

摘要： The invention relates to a microsensor device like a magnetic biosensor (100). The microsensor device comprises an array of probe-sensors (10.1, 10.2, 10.3) for the measurement of a physical quantity, for example the concentration of molecules labeled with magnetic beads in a sample chamber. The array further comprises a reference-sensor (10.4) that is disposed close to the probe-sensors (10.1, 10.2, 10.3) but shielded from the physical quantity to be measured. The measuring signal of the reference-sensor (10.4) reflects the influence of environmental conditions like temperature and can therefore be used to correct the measuring signals of the probe-sensors (10.1, 10.2, 10.3). The sensors (10.1, 10.2, 10.3, 10.4) are connected via a multiplexer to the same detector unit for further processing in order to minimize variations and to reduce hardware complexity.

摘要翻译： 本发明涉及一种诸如磁性生物传感器（100）的微传感器装置。 微传感器装置包括用于测量物理量的探针传感器阵列（10.1,10.2,10.3），例如在样品室中用磁珠标记的分子的浓度。 该阵列还包括靠近探头传感器（10.1,10.2,10.3）设置但与被测量的物理量屏蔽的参考传感器（10.4）。 参考传感器（10.4）的测量信号反映了诸如温度等环境条件的影响，因此可用于校正探头传感器（10.1,10.2,10.3）的测量信号。 传感器（10.1,10.2,10.3,10.4）通过多路复用器连接到相同的检测器单元以进行进一步处理，以便最小化变化并降低硬件复杂度。

公开(公告)号：US10092903B2

公开(公告)日：2018-10-09

申请号：US12809208

申请日：2008-12-16

申请人： Menno Willem Jose Prins ,  Joost Hubert Maas ,  Albert Hendrik Jan Immink ,  Dirkjan Bernhard Van Dam ,  Maatje Koets ,  Michel J. M. Bruyninckx ,  Thea Van Der Wijk ,  Marius Iosif Boamfa ,  Remco Den Dulk

发明人： Menno Willem Jose Prins ,  Joost Hubert Maas ,  Albert Hendrik Jan Immink ,  Dirkjan Bernhard Van Dam ,  Maatje Koets ,  Michel J. M. Bruyninckx ,  Thea Van Der Wijk ,  Marius Iosif Boamfa ,  Remco Den Dulk

IPC分类号： B01L3/00

摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

公开(公告)号：US20110301047A1

公开(公告)日：2011-12-08

申请号：US13140175

申请日：2009-12-07

申请人： Albert Hendrik Jan Immink ,  Albert F. Gootzen ,  Dirk Jan Nelly Vananderoye ,  Petrus Johannes Wilhelmu Van Lankvelt

发明人： Albert Hendrik Jan Immink ,  Albert F. Gootzen ,  Dirk Jan Nelly Vananderoye ,  Petrus Johannes Wilhelmu Van Lankvelt

IPC分类号： C40B30/00 ,  C12Q1/70 ,  C40B60/12 ,  C12Q1/02 ,  C12M1/34 ,  G01N33/566 ,  C12Q1/00 ,  G01N33/53

CPC分类号： G01N33/54373 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/048 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2400/0481 ,  G01N21/03 ,  G01N21/11 ,  G01N21/552 ,  G01N2021/0346

摘要： The invention relates to a sensing device for sensing a fluid. The sensing device comprises an inlet port (20) for receiving the fluid (100) and a measurement chamber (25) for sensing the fluid (100). The sensing device further comprises a fluid channel (30) coupling the inlet port (20) and the measurement chamber (25) for transporting the fluid (100) from the inlet port (20) to the measurement chamber (25) and a fluid stop unit (50) for stopping and controllably releasing the flow of fluid between the inlet port (20) and the measurement chamber (25). This allows stopping the fluid before reaching the measurement chamber (25) and controllably releasing the fluid for allowing the fluid to flow into the measurement chamber (25), if the sensing device is ready for analyzing the fluid.

摘要翻译： 本发明涉及一种感测流体的感测装置。 感测装置包括用于接收流体（100）的入口（20）和用于感测流体（100）的测量室（25）。 感测装置还包括连接入口（20）和测量室（25）的流体通道（30），用于将流体（100）从入口（20）输送到测量室（25）和流体停止 单元（50），用于停止和可控地释放入口（20）和测量室（25）之间的流体流。 这允许在到达测量室（25）之前停止流体，并且如果感测装置准备好用于分析流体，则可控地释放流体以允许流体流入测量室（25）。

公开(公告)号：US20100289483A1

公开(公告)日：2010-11-18

申请号：US12669218

申请日：2008-07-16

申请人： Albert Hendrik Jan Immink ,  Femke Karina De Theije ,  Menno Willem Jose Prins ,  Wendy Uyen Dittmer ,  Jeroen Hans Nieuwenhuis

发明人： Albert Hendrik Jan Immink ,  Femke Karina De Theije ,  Menno Willem Jose Prins ,  Wendy Uyen Dittmer ,  Jeroen Hans Nieuwenhuis

IPC分类号： G01N27/74

CPC分类号： G01R33/1269

摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).

摘要翻译： 本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。 传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。 第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，并且第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b） 的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。 本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。