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    Method for Detecting the Activatable Free Form of Psa and the Use Thereof for Diagnosing Benign Pathologies of the Prostate and Adenocarcinoma of the Prostate
    5.
    发明申请
    Method for Detecting the Activatable Free Form of Psa and the Use Thereof for Diagnosing Benign Pathologies of the Prostate and Adenocarcinoma of the Prostate 审中-公开
    检测Psa可活化自由形式的方法及其用途，用于诊断前列腺前列腺和腺癌的良性病理

    公开(公告)号：US20070254317A1

    公开(公告)日：2007-11-01

    申请号：US10590272

    申请日：2005-03-01

    申请人： Sandrine Busseret-Michel ,  Colette Jolivet-Reynaud

    发明人： Sandrine Busseret-Michel ,  Colette Jolivet-Reynaud

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57434 ,  G01N2333/96455

    摘要： The present invention relates to a method for the in vitro diagnosing of a benign pathology of the prostate or of an adenocarcinoma of the prostate, characterized in that it comprises the step consisting of detection, in a biological sample from a patient suspected of suffering from a benign pathology of the prostate or from an adenocarcinoma of the prostate, of the activatable free form of PSA. This method of diagnosis can be carried out by means of the steps consisting in: i) bringing a binding partner capable of binding specifically to activatable free PSA into contact with a biological sample from a patient suspected of suffering from a benign pathology of the prostate or of an adenocarcinoma of the prostate, ii) demonstrating the capture of the activatable free form of PSA by said binding partner, iii) calculating the ratio of the amount of activatable free form of PSA detected in step ii) to the amount of a form of PSA other than the activatable free form, present in a sample of the same nature taken from the same individual, and iv) determining whether the patients are suffering from an adenocarcinoma of the prostate or from a benign pathology of the prostate by comparing the value of the ratio determined in step iii) with a predetermined threshold value, chosen according to the type of ratio used and representative of the detection limit of each pathology.

    摘要翻译： 本发明涉及用于体外诊断前列腺或前列腺腺癌的良性病理学的方法，其特征在于它包括以下步骤：检测来自怀疑患有 前列腺的良性病理学或来自前列腺的腺癌的可激活的游离形式的PSA。 这种诊断方法可以通过以下步骤进行：i）使能够特异性结合可活化游离PSA的结合配偶体与怀疑患有前列腺良性病变的患者的生物样品接触，或 的前列腺腺癌，ii）证明通过所述结合配偶体捕获可激活的游离形式的PSA，iii）计算在步骤ii）中检测到的PSA的可活化游离形式的量与所述结合配偶体形式的量的比例 存在于从相同个体获得的相同性质的样品中的PSA以外的PSA，以及iv）通过比较前列腺的患者是否患有前列腺腺癌或从前列腺的良性病理确定 根据所使用的比例类型选择具有预定阈值的步骤iii）中确定的比例，并代表每个病理学的检测限。