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    EXTRACTION OF cfDNA FROM BIOLOGICAL SAMPLES
    2.
    发明申请
    EXTRACTION OF cfDNA FROM BIOLOGICAL SAMPLES 审中-公开

    公开(公告)号：US20170283788A1

    公开(公告)日：2017-10-05

    申请号：US15473672

    申请日：2017-03-30

    申请人： Covaris, Inc.

    发明人： Hamid Khoja ,  Hans-Ulrich Thomann ,  James A. Laugharn, JR.

    IPC分类号： C12N15/10 ,  C12N13/00

    摘要： Focused acoustic treatment of samples including a target biomolecule, such as cfDNA, may aid in the recovery of the biomolecule from a sample. cfDNA in a sample, whether chemically stabilized or not, may be linked or otherwise bound to histones or other proteins, e.g., by hydrogen bonds of histones or chaperone proteins to DNA and/or covalent crosslinks of such proteins to the DNA. Focused acoustic energy may remove or disrupt such links, aiding in isolation of the cfDNA from the sample.

    METHOD AND APPARATUS FOR PROCESSING SAMPLE MATERIAL
    5.
    发明申请
    METHOD AND APPARATUS FOR PROCESSING SAMPLE MATERIAL 有权
    处理样品的方法和装置

    公开(公告)号：US20150079655A1

    公开(公告)日：2015-03-19

    申请号：US14028771

    申请日：2013-09-17

    申请人： Covaris, Inc.

    发明人： James A. Laugharn, JR. ,  Xiaoyin He ,  Srikanth Kakumanu

    IPC分类号： B01D43/00 ,  A61L2/10 ,  C12N13/00 ,  G01N1/34 ,  G01N1/38

    CPC分类号： B01D43/00 ,  A61L2/10 ,  B01L7/00 ,  B01L2200/147 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/0436 ,  B01L2400/0439 ,  C12N13/00 ,  G01N1/34 ,  G01N1/38

    摘要： Methods and systems for treating material with focused acoustic energy and/or ultraviolet radiation are described. Sample material may be provided to a single batch vessel or may flow in a continuous or intermittent fashion into/out of a processing chamber within which the material is exposed to focused acoustic energy and/or ultraviolet radiation. Exposure to focused acoustics in a flow through environment may enhance the effects of the radiation on the sample material. Further, in flow-through or single batch arrangements, sample material may be retained exterior to or within a processing chamber by one or more retaining members (e.g., filter, valve, etc.) until a characteristic of the sample material reaches one or more particular criteria (e.g., physical, chemical, biological). Once the criteria of the sample material is attained (e.g., via further treatment), the material is then permitted to flow past the retaining member(s) and through the inlet or outlet of the chamber. Further, focused acoustic processing may be used to treat articles, such as the retaining member(s), rather than only sample material located within an internal processing volume of the chamber.

    摘要翻译： 描述了用聚焦声能和/或紫外线辐射处理材料的方法和系统。 样品材料可以提供给单个批量容器，或者可以以连续或间歇的方式流入/离开处理室，在该处理室内材料暴露于聚焦的声能和/或紫外线辐射。 在流过环境中暴露于聚焦声学可能会增强辐射对样品材料的影响。 此外，在流通或单批次布置中，样品材料可以通过一个或多个保持构件（例如，过滤器，阀等）保持在处理室的外部或内部，直到样品材料的特性达到一个或多个 特定标准（如物理，化学，生物学）。 一旦获得样品材料的标准（例如通过进一步处理），则允许材料流过保持构件并通过腔室的入口或出口。 此外，聚焦声学处理可以用于处理诸如保持构件的制品，而不仅仅是位于室的内部处理容积内的样品材料。

    ACOUSTIC ENERGY TREATMENT USING PHASE CHANGE COUPLANT
    7.
    发明申请
    ACOUSTIC ENERGY TREATMENT USING PHASE CHANGE COUPLANT 审中-公开
    使用相位变化耦合的声学能量治疗

    公开(公告)号：US20160186126A1

    公开(公告)日：2016-06-30

    申请号：US14970969

    申请日：2015-12-16

    申请人： Covaris, Inc.

    发明人： James A. Laugharn, JR.

    IPC分类号： C12N1/06 ,  C12N13/00

    CPC分类号： C12N1/066 ,  C12M45/02 ,  C12M47/06 ,  C12N13/00

    摘要： Method and apparatus for transmitting acoustic energy to a sample for treatment by employing a phase change couplant at least adjacent a sample vessel. The phase change couplant may be solid before and after treatment, but liquid during treatment to improve acoustic energy transmission charactersitics.

    摘要翻译： 用于通过使用至少相邻于样品容器的相变耦合剂将声能传递到样品进行处理的方法和装置。 相变耦合剂在处理前后可能是固体，而在处理过程中液体可以改善声能传播特性。

    METHOD AND APPARATUS FOR HEADSPACE CONTROL IN ACOUSTIC PROCESSING OF SAMPLES
    8.
    发明申请
    METHOD AND APPARATUS FOR HEADSPACE CONTROL IN ACOUSTIC PROCESSING OF SAMPLES 有权
    方法和装置在样本的声学处理中的头部控制

    公开(公告)号：US20150166979A1

    公开(公告)日：2015-06-18

    申请号：US14634042

    申请日：2015-02-27

    申请人： Covaris, Inc.

    发明人： James A. Laugharn, JR.

    IPC分类号： C12N13/00

    CPC分类号： C12N13/00 ,  B01F11/0283 ,  B01J2219/00308 ,  B01J2219/00344 ,  B01J2219/00486 ,  B01J2219/00722 ,  B01J2219/0074 ,  G01N1/286 ,  G01N2035/00554

    摘要： Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.

    摘要翻译： 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件来控制样品进行声学处理的处理体积，以减少和/或消除样品/气体界面处的顶空尺寸。 可以例如通过使用至少部分定位在样品中的顶空控制元件来控制声能和样品之间的相互作用，所述顶空控制元件有助于减少否则会发生的飞溅或其它样品喷射。

    METHOD AND SYSTEM FOR ACOUSTICALLY TREATING MATERIAL
    9.
    发明申请
    METHOD AND SYSTEM FOR ACOUSTICALLY TREATING MATERIAL 有权
    用于声处理材料的方法和系统

    公开(公告)号：US20130244285A1

    公开(公告)日：2013-09-19

    申请号：US13891554

    申请日：2013-05-10

    申请人： COVARIS, INC.

    发明人： James A. Laugharn, JR. ,  Carl Beckett ,  Xiaoyin He

    IPC分类号： C12N13/00 ,  A61L2/025

    CPC分类号： B01J19/10 ,  A61L2/025 ,  B01F3/08 ,  B01F3/12 ,  B01F11/02 ,  B01F11/0283 ,  B01F2215/0037 ,  B01J19/006 ,  B01J19/008 ,  B01J19/245 ,  B01J2219/00094 ,  C12N13/00

    摘要： Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window, a heat exchanger, inlet/outlet flow arrangements, an inspection window, insert elements that define a treatment volume size or shape, etc. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.

    摘要翻译： 使用连续方法来声学处理材料的方法和系统，其中可以使材料以连续或间歇的方式流入/离开材料暴露于聚焦声能的声学处理室。 方法和系统可以被布置成允许在较长时间内连续处理，同时声能源以相对高的功率输出操作。 治疗室可以包括诸如声窗，热交换器，入口/出口流布置，检查窗，限定治疗体积大小或形状的插入元件等特征。与治疗室相对于治疗室的布置有关的治疗系统构型 提供声源和耦合介质，材料流动路径等。

    SAMPLE HOLDER AND METHOD FOR FRAGMENTING SAMPLE MATERIAL
    10.
    发明申请
    SAMPLE HOLDER AND METHOD FOR FRAGMENTING SAMPLE MATERIAL 有权
    样品保持器和样品样品的方法

    公开(公告)号：US20130160576A1

    公开(公告)日：2013-06-27

    申请号：US13681582

    申请日：2012-11-20

    申请人： Covaris, Inc.

    发明人： James A. Laugharn, JR. ,  Ion A. Tsinteris

    IPC分类号： G01N1/28

    CPC分类号： G01N1/28 ,  G01N1/286 ,  G01N1/42 ,  G01N2001/2866

    摘要： Method and apparatus for holding and/or treating a sample material. A sample may be positioned in a vessel and a crushing force may be applied to the sample material while in the vessel, e.g., by a plunger that is part of a cap to pulverize the sample at cryogenic temperatures. The sample holder may include an acoustic window arranged to admit acoustic energy into the vessel for acoustic treatment of the sample. A flexible film may be used at a portion of the vessel, e.g., at the acoustic window, to cooperate with a plunger for crushing a sample.

    摘要翻译： 用于保持和/或处理样品材料的方法和设备。 样品可以定位在容器中，并且可以在容器中例如通过作为帽的一部分的柱塞在低温下粉碎样品的样品材料施加破碎力。 样品保持器可以包括布置成将声能吸收到容器中以用于对样品进行声学处理的声窗口。 可以在容器的一部分，例如在声窗上使用柔性膜，以与用于粉碎样品的柱塞配合。