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公开(公告)号:US6156540A
公开(公告)日:2000-12-05
申请号:US171817
申请日:1993-12-22
申请人: Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
发明人: Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
CPC分类号: C07K14/8121
摘要: There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevention of blood clotting is necessary and is of therapeutic value. The present invention also discloses a method of producing the anti-thrombin polypeptide and methods for its use as a pharmaceutical composition.
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公开(公告)号:US6133422A
公开(公告)日:2000-10-17
申请号:US200965
申请日:1998-11-30
申请人: Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
发明人: Craig A. Rosen , Liang Cao , Mark D. Adams , Rebecca A. Fuldner
CPC分类号: C07K14/8121
摘要: There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevention of blood clotting is necessary and is of therapeutic value. The present invention also discloses a method of producing the anti-thrombin polypeptide and methods for its use as a pharmaceutical composition.
摘要翻译: 提供了一种凝血酶抑制剂多肽和编码这种多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法。 抗凝血酶多肽用于治疗需要预防血液凝固并具有治疗价值的各种疾病。 本发明还公开了一种生产抗凝血酶多肽的方法及其用作药物组合物的方法。
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公开(公告)号:US06610477B1
公开(公告)日:2003-08-26
申请号:US08465679
申请日:1995-06-06
申请人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
发明人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
IPC分类号: C12Q168
CPC分类号: C07K14/47 , Y10T436/143333
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA),以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3,而hMLH2已被映射到染色体2,并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。
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公开(公告)号:US06620619B2
公开(公告)日:2003-09-16
申请号:US08210143
申请日:1994-03-16
申请人: William A. Haseltine , Steven Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Craig A. Rosen , Rebecca A. Fuldner , Ewen F. Kirkness
发明人: William A. Haseltine , Steven Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Craig A. Rosen , Rebecca A. Fuldner , Ewen F. Kirkness
IPC分类号: G01N3306
CPC分类号: C07K14/47
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA)。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
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公开(公告)号:US06482606B1
公开(公告)日:2002-11-19
申请号:US08187757
申请日:1994-01-27
申请人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号: C12P2102
CPC分类号: C07K14/47
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA)。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
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公开(公告)号:US06416984B1
公开(公告)日:2002-07-09
申请号:US08468024
申请日:1995-06-06
申请人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
发明人: William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
IPC分类号: C12N900
CPC分类号: C07K14/47 , Y10T436/143333
摘要: The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA),以及通过重组技术生产此类蛋白质的方法。 人类DNA修复蛋白hMLH1已被映射到染色体3,而hMLH2已被映射到染色体2,并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗 遗传易感性癌症。
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公开(公告)号:US06380369B1
公开(公告)日:2002-04-30
申请号:US08294312
申请日:1994-08-23
申请人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人: Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号: C07H2102
CPC分类号: C07K14/47
摘要: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins which may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译: 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA(RNA)。 可通过重组DNA技术产生的DNA修复蛋白。 人类DNA修复蛋白hMLH1已经被映射到染色体3,而hMLH2已被映射到染色体2,并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可以用于诊断遗传易感性 到癌症。
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公开(公告)号:US5633147A
公开(公告)日:1997-05-27
申请号:US208008
申请日:1994-03-08
IPC分类号: G01N33/53 , A61K31/70 , A61K38/00 , A61K38/27 , A61K38/55 , A61K39/395 , A61K48/00 , A61P1/16 , A61P13/02 , A61P15/00 , A61P27/02 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/495 , C07K16/22 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/08 , C12R1/19 , C12N15/63
CPC分类号: C07K14/495 , A61K38/00 , A61K48/00 , C12N2799/026
摘要: Disclosed is a human TGF.alpha.-H1 polypeptide and DNA (RNA) encoding such TGF.alpha.-H1 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and for producing antibodies and antagonists against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. Also provided, are methods of using the antibodies and antagonists to inhibit TGF.alpha.-H1 for therapeutic purposes.
摘要翻译: 公开了人TGFα-H1多肽和编码这种TGFα-H1多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽并用于产生抗这种多肽的抗体和拮抗剂的方法。 这样的多肽可以与合适的药物载体或稀释剂组合以提供针对各种疾病的诊断,治疗和/或预防效果。 还提供了使用抗体和拮抗剂抑制TGFα-H1用于治疗目的的方法。
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公开(公告)号:US06265543B1
公开(公告)日:2001-07-24
申请号:US08915096
申请日:1997-08-20
IPC分类号: C07K14495
CPC分类号: C07K14/495 , A61K38/00 , A61K48/00 , C12N2799/026
摘要: The present invention discloses transforming growth factor alpha HI polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译: 本发明公开了转化生长因子αHI多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法,其包括刺激伤口愈合,治疗神经障碍,治疗眼部疾病,治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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公开(公告)号:US6074839A
公开(公告)日:2000-06-13
申请号:US468846
申请日:1995-06-06
IPC分类号: C12N15/09 , A61K31/70 , A61K31/711 , A61K38/00 , A61K38/22 , A61K38/27 , A61K38/55 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P9/00 , A61P13/02 , A61P13/12 , A61P15/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P25/28 , A61P27/02 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/495 , C07K16/22 , C12N1/21 , C12N15/12 , C12P21/08 , C12Q1/68 , C12R1/19 , G01N33/53 , C12N5/10 , C12N15/63
CPC分类号: C07K14/495 , A61K38/00 , A61K48/00 , C12N2799/026
摘要: The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译: 本发明公开了转化生长因子αHII多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法,其包括刺激伤口愈合,治疗神经障碍,治疗眼部疾病,治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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