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33 条记录 (耗时 0.113 秒)

    RNA ENCODING A THERAPEUTIC PROTEIN
    1.
    发明申请
    RNA ENCODING A THERAPEUTIC PROTEIN 有权

    公开(公告)号：US20220025369A1

    公开(公告)日：2022-01-27

    申请号：US17359902

    申请日：2021-06-28

    申请人： CureVac AG

    发明人： Mariola FOTIN-MLECZEK ,  Ingmar HOERR

    IPC分类号： C12N15/113 ,  A61K45/06 ,  A61K31/7105

    摘要： The present invention relates to an RNA encoding a therapeutic protein. In particular, the present invention relates to RNA suitable for use as a medicament. The present invention concerns such novel RNA as well as compositions and kits comprising the RNA. Furthermore, the present invention relates to the RNA, compositions or kits as disclosed herein for use as a medicament. The present invention also provides the use of the RNA, compositions or kits as disclosed herein for increasing the expression of said encoded protein, in particular in gene therapy.

    NUCLEIC ACIDS COMPRISING FORMULA (NuGlXmGnNv)a AND DERIVATIVES THEREOF AS IMMUNOSTIMULATING AGENT/ADJUVANT
    6.
    发明申请
    NUCLEIC ACIDS COMPRISING FORMULA (NuGlXmGnNv)a AND DERIVATIVES THEREOF AS IMMUNOSTIMULATING AGENT/ADJUVANT 有权

    公开(公告)号：US20220401555A1

    公开(公告)日：2022-12-22

    申请号：US17809680

    申请日：2022-06-29

    申请人： CureVac AG

    发明人： Thomas KRAMPS ,  Söhnke VOSS ,  Jochen PROBST ,  Ingmar HOERR

    IPC分类号： A61K39/39 ,  C07H21/00 ,  C12N15/117

    摘要： The present invention relates to nucleic acids of the general formula (I): (NuGlXmGnNv)a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to the use of the pharmaceutical composition or of the vaccine for the treatment of cancer diseases, infectious diseases, allergies and autoimmune diseases etc. Likewise, the present invention includes the use of nucleic acids of the general formula (I): (NuGlXmGnNv)a and/or derivatives thereof for the preparation of a pharmaceutical composition for the treatment of such diseases.

    NUCLEIC ACID OF FORMULA (I): GlXmGn, OR (II): ClXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT
    7.
    发明申请
    NUCLEIC ACID OF FORMULA (I): GlXmGn, OR (II): ClXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT 审中-公开

    公开(公告)号：US20200016264A1

    公开(公告)日：2020-01-16

    申请号：US16581017

    申请日：2019-09-24

    申请人： CureVac AG

    发明人： Ingmar HOERR ,  Jochen PROBST ,  Thomas KETTERER ,  Birgit SCHEEL

    IPC分类号： A61K39/39

    摘要： The present invention relates to a nucleic acid of the general formula (I): GlXmGn, or (II): ClXmCn, which may be modified by a lipid. The nucleic acid of the invention acts as an immune-stimulating agent inducing the innate immune response. The invention relates further to a pharmaceutical composition (in a first embodiment), each containing an immune-stimulating agent according to the invention in combination with a pharmaceutically active carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). In another embodiment, the inventive nucleic acid is combined with at least one pharmaceutically active component, a pharmaceutically acceptable carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). Accordingly, the present invention is directed to a vaccine, which corresponds to a pharmaceutical composition of the invention (second embodiment), wherein the pharmaceutically active component induces a specific immune response (e.g. an antigen). The present invention relates likewise to the use of a nucleic acid of the invention or a pharmaceutical composition according to the invention for the treatment of infectious diseases, autoimmune diseases, allergies or cancer diseases.

    NUCLEIC ACIDS COMPRISING FORMULA (NuGlXmGnNv)a AND DERIVATIVES THEREOF AS IMMUNOSTIMULATING AGENT/ADJUVANT
    10.
    发明申请
    NUCLEIC ACIDS COMPRISING FORMULA (NuGlXmGnNv)a AND DERIVATIVES THEREOF AS IMMUNOSTIMULATING AGENT/ADJUVANT 审中-公开
    包含其中的核酸（NuGlXmGnNv）及其衍生物作为免疫抑制剂/调节剂

    公开(公告)号：US20160250321A1

    公开(公告)日：2016-09-01

    申请号：US14954363

    申请日：2015-11-30

    申请人： CureVac AG

    发明人： Thomas KRAMPS ,  Söhnke VOSS ,  Jochen PROBST ,  Ingmar HOERR

    IPC分类号： A61K39/39 ,  C12N15/117

    CPC分类号： A61K39/39 ,  A61K2039/53 ,  A61K2039/55561 ,  A61K2039/572 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2320/31 ,  Y02A50/487

    摘要： The present invention relates to nucleic acids of the general formula (I): (NuGlXmGnNv)a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to the use of the pharmaceutical composition or of the vaccine for the treatment of cancer diseases, infectious diseases, allergies and autoimmune diseases etc. Likewise, the present invention includes the use of nucleic acids of the general formula (I): (NuGlXmGnNv)a and/or derivatives thereof for the preparation of a pharmaceutical composition for the treatment of such diseases.

    摘要翻译： 本发明涉及通式（I）的核酸：（NuG1XmGnNv）a及其衍生物作为免疫刺激剂/佐剂和含有其的组合物，任选地包含另外的佐剂。 本发明还涉及药物组合物或疫苗，其各自含有上述式（I）核酸和/或其衍生物作为免疫刺激剂，以及任选的至少一种另外的药物活性成分，例如， 抗原剂。 本发明同样涉及药物组合物或疫苗用于治疗癌症疾病，感染性疾病，过敏症和自身免疫疾病等的用途。同样地，本发明包括通式（I）的核酸， ：（NuGlXmGnNv）a和/或其衍生物，用于制备用于治疗这些疾病的药物组合物。