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公开(公告)号：US11583819B2
公开(公告)日：2023-02-21
申请号：US16817299
申请日：2020-03-12
IPC分类号： A61K9/14 , B01J2/00 , C07K14/78 , A61L31/16 , A61L27/34 , A61L29/08 , A61L31/10 , C12M1/00 , B01J13/06 , C07K19/00 , A61K38/00 , B01J2/06 , A61L27/54
摘要： Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.
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公开(公告)号：US20150118692A1
公开(公告)日：2015-04-30
申请号：US14388508
申请日：2013-03-15
申请人： DUKE UNIVERSITY
IPC分类号： G01N33/545 , C08F30/08
CPC分类号： G01N33/545 , C08F30/08 , C08G77/04 , C08L83/04 , G01N33/538 , G01N33/54313 , G01N33/585
摘要： Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast acoustic particles, wherein the particles can contain a functional group available for covalent modification.
摘要翻译： 提供声响应颗粒和方法供其使用。 提供了制备和使用可调谐单分散声响应颗粒和负对比声学颗粒的方法，其中颗粒可以含有可用于共价修饰的官能团。
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公开(公告)号：US20140230854A1
公开(公告)日：2014-08-21
申请号：US14347672
申请日：2012-09-28
申请人： DUKE UNIVERSITY
IPC分类号： B08B7/02
CPC分类号： B08B7/02 , A01N25/34 , A61M25/0017 , A61M25/0023 , A61M2025/0019 , A61M2025/0024 , A61M2025/0025 , B08B17/06
摘要： Disclosed herein are devices and methods for active biofouling control. According to an aspect, a device comprising a surface for contacting a biological material. The device also comprises a mechanism comprising a structure configured to change the surface between a first shape and a second shape. The change from the first shape to the second shape deforms the surface beyond a critical strain for debonding of a fouling agent from the surface when the fouling agent has bonded to the surface in the first shape.
摘要翻译： 本文公开了用于主动生物污垢控制的装置和方法。 根据一方面，一种包括用于接触生物材料的表面的装置。 该装置还包括一种机构，其包括构造成在第一形状和第二形状之间改变表面的结构。 当第一形状到第二形状的变化使得当污垢结合到第一形状的表面时，表面超过用于从表面剥离污垢剂的临界应变。
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4.发明申请公开(公告)号：US20180289924A1
公开(公告)日：2018-10-11
申请号：US15769592
申请日：2016-10-28
申请人： Duke University
IPC分类号： A61M25/00
摘要： Catheters for debonding fouling agents from an interior surface thereof and related methods are disclosed. According to an aspect, a catheter includes a lumen defining a flexible, interior surface that extends substantially along a length of the lumen for contacting a biological material. The catheter also includes cavities extending along the length and positioned within the lumen adjacent to the surface. The cavities each define a cavity opening. The catheter also includes an inflation hub defining hub openings connected to respective cavity openings. The inflation hub defines a pump port configured to interface with a pump. The inflation hub defines one or more fluid pathways that extend between the hub openings and the pump port for permitting flow of gas between the pump and the cavities.
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公开(公告)号：US10016756B2
公开(公告)日：2018-07-10
申请号：US15466998
申请日：2017-03-23
申请人： Duke University
发明人： Gabriel P. Lopez
CPC分类号： B01L3/0275 , B01L2200/0652 , B01L2200/0668 , B01L2300/0832 , B01L2300/0858 , B01L2400/0433 , G01N1/4077 , G01N2001/4094 , G01N2015/1006 , G01N2035/1048
摘要： A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. The pipette tip may define an acoustic channel configured for allowing flow-through of a liquid. The kit may also include a vibratory device in communication with the acoustic channel and configured for imparting a vibratory force thereto. The impartation of the vibratory force may create standing acoustic waves, thereby separating any negative acoustic contrast particles (NACPs) from the remaining contents of the liquid sample. The NACPs may capable of biospecific recognition of the analyte of interest, thereby separating the analytes of interest, which can then be collected or analyzed accordingly.
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公开(公告)号：US11268127B2
公开(公告)日：2022-03-08
申请号：US15116750
申请日：2015-02-04
IPC分类号： C12Q1/37 , G01N33/573
摘要： The presently disclosed subject matter relates to modular peptide-substrate protease assays, in particular low cost and reliable methodology for measurement of protease and other enzyme activity that may be detected by optical turbidimetry or visual observation. The presently disclosed subject matter also relates to methods of using the disclosed assays within methods of detecting and monitoring diseases, methods of drug discovery, as well as in detection devices and systems.
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公开(公告)号：US10238586B2
公开(公告)日：2019-03-26
申请号：US15492786
申请日：2017-04-20
申请人： Duke University
摘要： A composition and method is provided for synthesizing silicone particles with narrow size distributions and tunable degrees of crosslinking for encapsulation of an active ingredient or multiple active ingredients in the matrix of the particles for controlled release. The method comprises agitating at least one type of silane monomer having two, three or four siloxane bonds in an acidic aqueous solution under conditions sufficient to allow for hydrolysis of the monomers, adding a catalyst and a solution comprising a co-solvent and the active ingredient(s) to the acidic aqueous solution, and continuing to agitate the combined solution to allow for a condensation reaction and formation of silicone particles with a narrow size distribution encapsulating at least a portion of the active ingredient(s). The tunable degree of crosslink density of the particles formed is based on the ratios of the monomers used, which enables controlled release of the active ingredient(s) from the particles.
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公开(公告)号：US10207299B2
公开(公告)日：2019-02-19
申请号：US14347672
申请日：2012-09-28
申请人： DUKE UNIVERSITY
IPC分类号： A61M5/32 , B08B7/02 , A01N25/34 , A61M25/00 , A61M27/00 , A61F5/44 , B65D83/10 , B65D81/02 , B08B17/06
摘要： Disclosed herein are devices and methods for active biofouling control. According to an aspect, a device comprising a surface for contacting a biological material. The device also comprises a mechanism comprising a structure configured to change the surface between a first shape and a second shape. The change from the first shape to the second shape deforms the surface beyond a critical strain for debonding of a fouling agent from the surface when the fouling agent has bonded to the surface in the first shape.
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公开(公告)号：US20180318828A1
公开(公告)日：2018-11-08
申请号：US16026581
申请日：2018-07-03
申请人： Duke University
发明人： Gabriel P. Lopez
CPC分类号： B01L3/0275 , B01L2200/0652 , B01L2200/0668 , B01L2300/0832 , B01L2300/0858 , B01L2400/0433 , G01N1/4077 , G01N2001/4094 , G01N2015/1006 , G01N2035/1048
摘要： A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette. The pipette tip may define an acoustic channel configured for allowing flow-through of a liquid. The kit may also include a vibratory device in communication with the acoustic channel and configured for imparting a vibratory force thereto. The impartation of the vibratory force may create standing acoustic waves, thereby separating any negative acoustic contrast particles (NACPs) from the remaining contents of the liquid sample. The NACPs may capable of biospecific recognition of the analyte of interest, thereby separating the analytes of interest, which can then be collected or analyzed accordingly.
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公开(公告)号：US20160271262A1
公开(公告)日：2016-09-22
申请号：US15074132
申请日：2016-03-18
申请人： Duke University
CPC分类号： A61K47/64 , A61K9/06 , A61K47/6907 , A61L27/227 , A61L27/52 , A61L2300/252 , A61L2300/626 , C07K14/78 , C08J3/075 , C08J2389/00
摘要： The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.
摘要翻译： 目前公开的主题涉及包含其的组合物，方法和系统（例如，平台），所述系统包含由多肽胶束形成的微水凝胶和大水凝胶，或由其组成。 这些系统具有增强的机械性能，其可用于各种应用中，可用于控制释放载药胶束，并且可以设计成可按要求可逆地组装和拆卸。
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