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    Hybrid spectral domain optical coherence tomography line scanning laser ophthalmoscope
    2.
    发明申请
    Hybrid spectral domain optical coherence tomography line scanning laser ophthalmoscope 失效
    混合光谱光学相干断层扫描线扫描激光检眼镜

    公开(公告)号：US20070263171A1

    公开(公告)日：2007-11-15

    申请号：US11799315

    申请日：2007-05-01

    申请人： R. Ferguson ,  Daniel Hammer ,  Nicusor Iftimia ,  Chad Bigelow

    发明人： R. Ferguson ,  Daniel Hammer ,  Nicusor Iftimia ,  Chad Bigelow

    IPC分类号： A61B3/14

    CPC分类号： A61B3/102 ,  A61B3/1025 ,  G01B9/0203 ,  G01B9/02044 ,  G01B9/02091

    摘要： An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

    摘要翻译： 用于对眼睛进行成像的装置包括壳体和设置在壳体中的光学部件的系统。 该装置能够以线扫描激光检眼镜（LSLO）模式和光学相干断层扫描（OCT）模式进行操作。 光学部件的系统可以包括用于为OCT模式提供第一光束的第一光源和用于为LSLO模式提供第二光束的第二光源。 在OCT模式中，使用第一光学器件，其（i）使用第一光学元件的第一表面沿着第一维度的眼睛的视网膜扫描第一光束，以及（ii）使用第一光学元件 表面，在OCT模式下从第一维度从眼睛返回到检测系统的第一光。 在LSLO模式中，第一光学器件用于第二光束穿过第一光学器件的第二表面。

    Method and apparatus for three-dimensional spectrally encoded imaging
    3.
    发明授权
    Method and apparatus for three-dimensional spectrally encoded imaging 有权
    用于三维光谱编码成像的方法和装置

    公开(公告)号：US07551293B2

    公开(公告)日：2009-06-23

    申请号：US10997789

    申请日：2004-11-24

    申请人： Dvir Yelin ,  Brett E. Bouma ,  Nicusor Iftimia ,  Guillermo J. Tearney

    发明人： Dvir Yelin ,  Brett E. Bouma ,  Nicusor Iftimia ,  Guillermo J. Tearney

    IPC分类号： G01J3/45 ,  G01B9/02 ,  G01B11/02

    CPC分类号： G01B11/2441 ,  A61B1/042 ,  A61B5/1077 ,  G01B9/02027 ,  G01B9/02044 ,  G01B11/2509

    摘要： A method and apparatus for providing information associated with at least one portion of a sample can be provided. For example, at least one wavelength of electro-magnetic radiation provided on a sample can be encoded to determine at least one transverse location of the portion. A relative phase between at least one first electro-magnetic radiation electro-magnetic radiation being returned from a sample and at least one second electro-magnetic radiation returned from a reference can be obtained to determine at least one relative depth location of the portion. Further, the information of the portion can be provided based on the transverse location and the relative depth location. For example, the information can be depth information and/or three-dimensional information associated with the portion of the sample.

    摘要翻译： 可以提供用于提供与样本的至少一部分相关联的信息的方法和装置。 例如，可以对提供在样品上的至少一个电磁辐射波长进行编码，以确定该部分的至少一个横向位置。 可以获得从样品返回的至少一个第一电磁辐射电磁辐射与从参考物返回的至少一个第二电磁辐射之间的相对相位，以确定该部分的至少一个相对深度位置。 此外，可以基于横向位置和相对深度位置来提供该部分的信息。 例如，信息可以是与样本部分相关联的深度信息和/或三维信息。

    Spectrally-encoded endoscopy techniques, apparatus and methods
    4.
    发明授权
    Spectrally-encoded endoscopy techniques, apparatus and methods 有权
    光谱编码的内窥镜检查技术，仪器和方法

    公开(公告)号：US08818149B2

    公开(公告)日：2014-08-26

    申请号：US13427463

    申请日：2012-03-22

    申请人： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor Iftimia

    发明人： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor Iftimia

    IPC分类号： G02B6/32 ,  G02B6/34 ,  G02B6/06

    CPC分类号： G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

    摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can include a ball lens, and be configured to focus and provide there through the first electro-magnetic radiation to generate the focused electro-magnetic radiation. Further, the exemplary apparatus can include at least at least one dispersive third arrangement which can receive a particular radiation (e.g., the first electro-magnetic radiation(s) and/or the focused electro-magnetic radiation), and forward a dispersed radiation thereof to at least one section of the structure.

    摘要翻译： 可以提供用于获得结构信息的示例性装置。 例如，示例性装置可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。 示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。 第二布置可以包括球形透镜，并且被配置成通过第一电磁辐射聚焦并提供在其上，以产生聚焦的电磁辐射。 此外，示例性装置可以包括至少一个能够接收特定辐射（例如，第一电磁辐射和/或聚焦电磁辐射）的分散第三装置，并且将其分散的辐射 到结构的至少一个部分。

    Speckle reduction in optical coherence tomography by path length encoded angular compounding
    10.
    发明授权
    Speckle reduction in optical coherence tomography by path length encoded angular compounding 有权
    光学相干断层扫描中的斑点减少通过路径长度编码角复合

    公开(公告)号：US08174702B2

    公开(公告)日：2012-05-08

    申请号：US12510047

    申请日：2009-07-27

    申请人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett E. Bouma

    发明人： Guillermo J. Tearney ,  Nicusor Iftimia ,  Brett E. Bouma

    IPC分类号： G01B9/02 ,  G01B11/02

    CPC分类号： A61B5/0066 ,  A61B5/0059 ,  A61B5/6852 ,  G01B9/02028 ,  G01B9/02082 ,  G01B9/02087 ,  G01B9/02091 ,  G01J9/0215 ,  G01N21/4795 ,  G02B26/105 ,  G02B27/48

    摘要： Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

    摘要翻译： 斑点，减少光学相干断层扫描（“OCT”）中的图像质量的因素可能会限制识别对各种疾病的诊断重要的细胞结构的能力。 本发明的示例性实施例可以有助于通过路径长度编码（“ACPE”）实现角复合角度复合，以减少OCT图像中的斑点。 通过平均以不同入射角度获取的图像，每个图像由路径长度编码，ACPE保持高速图像采集，并对OCT探针光学元件进行最小修改。 从体内组织模型和人体皮肤获得的ACPE图像显示出比传统OCT和增加的信噪比（“SNR”）的定性改善。 因此，可以提供用于照射结构的装置探针导管和方法的示例性实施例。 具体地，干涉仪可以转发电磁辐射。 此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射结构的装置。 这种示例性布置可以被配置为相对于至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。