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    APPARATUS FOR OBTAINING INFORMATION FOR A STRUCTURE USING SPECTRALLY-ENCODED ENDOSCOPY TEACHNIQUES AND METHODS FOR PRODUCING ONE OR MORE OPTICAL ARRANGEMENTS
    2.
    发明申请
    APPARATUS FOR OBTAINING INFORMATION FOR A STRUCTURE USING SPECTRALLY-ENCODED ENDOSCOPY TEACHNIQUES AND METHODS FOR PRODUCING ONE OR MORE OPTICAL ARRANGEMENTS 有权
    用于获得使用分光编码的内窥镜教学结构的信息的装置以及用于生成一个或多个光学装置的方法

    公开(公告)号：US20070188855A1

    公开(公告)日：2007-08-16

    申请号：US11623852

    申请日：2007-01-17

    申请人： Milen Shishkov ,  Guillermo Tearney ,  Brett Bouma ,  Dvir Yelin ,  Nicusor Iftimia

    发明人： Milen Shishkov ,  Guillermo Tearney ,  Brett Bouma ,  Dvir Yelin ,  Nicusor Iftimia

    IPC分类号： G02B23/24 ,  A61B1/06

    CPC分类号： G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

    摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electromagnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electromagnetic radiation. Further, the exemplary apparatus can include at least one third dispersive arrangement which is configured to receive a particular radiation which is the first electromagnetic radiation and/or the focused electromagnetic radiation, and forward a dispersed radiation thereof to at least one section of the structure. At least one end of the fiber can be directly connected to the second focusing arrangement and/or the third dispersive arrangement. In addition, an exemplary embodiment of a method for producing an optical arrangement can be provided. For example, a first set of optical elements having a first size in a first configuration and a second set of optical elements in cooperation with the second set and having a second size in a second configuration can be provided. The first and second sets can be clamped into a third set of optical elements. The third set can be polished, and a further set of optical elements may be deposited on the polished set.

    摘要翻译： 可以提供用于获得结构信息的示例性装置。 例如，示例性设备可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。 示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。 第二布置可以被配置成通过第一电磁辐射聚焦并提供在那里。 此外，示例性装置可以包括至少一个第三分散装置，其被配置为接收作为第一电磁辐射和/或聚焦电磁辐射的特定辐射，并将其分散的辐射转发到该结构的至少一个部分。 光纤的至少一端可以直接连接到第二聚焦装置和/或第三色散装置。 此外，可以提供用于制造光学装置的方法的示例性实施例。 例如，可以提供具有第一配置的第一尺寸的第一组光学元件和与第二组配合并具有第二配置的第二尺寸的第二组光学元件。 第一组和第二组可以夹紧到第三组光学元件中。 可以抛光第三组，并且可以在抛光组上沉积另外的一组光学元件。

    Speckle reduction in optical coherence tomography by path length encoded angular compounding
    3.
    发明申请
    Speckle reduction in optical coherence tomography by path length encoded angular compounding 有权
    光学相干断层扫描中的斑点减少通过路径长度编码角复合

    公开(公告)号：US20060227333A1

    公开(公告)日：2006-10-12

    申请号：US10551735

    申请日：2004-03-31

    申请人： Guillermo Tearney ,  Nicusor Iftimia ,  Brett Bouma

    发明人： Guillermo Tearney ,  Nicusor Iftimia ,  Brett Bouma

    IPC分类号： G01B11/02

    CPC分类号： A61B5/0066 ,  A61B5/0059 ,  A61B5/6852 ,  G01B9/02028 ,  G01B9/02082 ,  G01B9/02087 ,  G01B9/02091 ,  G01J9/0215 ,  G01N21/4795 ,  G02B26/105 ,  G02B27/48

    摘要： Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. The present invention allows for an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, apparatus probe catheter, and method are provided for irradiating a sample. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the sample. Such arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

    摘要翻译： 斑点，减少光学相干断层扫描（“OCT”）中的图像质量的因素可能会限制识别对各种疾病的诊断重要的细胞结构的能力。 本发明允许通过路径长度编码（“ACPE”）实现角复合角度复合，以减少OCT图像中的斑点。 通过平均以不同入射角度获取的图像，每个图像由路径长度编码，ACPE保持高速图像采集，并对OCT探针光学元件进行最小修改。 从体内组织模型和人体皮肤获得的ACPE图像显示出比传统OCT和增加的信噪比（“SNR”）的定性改善。 因此，提供了用于照射样品的装置探针导管和方法。 具体地，干涉仪可以转发电磁辐射。 此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射样品的装置。 这种布置可以被配置为相对于至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。

    System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
    4.
    发明申请
    System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging 有权
    可以使用频谱编码外差干涉测量技术进行成像的系统，方法和布置

    公开(公告)号：US20060270929A1

    公开(公告)日：2006-11-30

    申请号：US11445131

    申请日：2006-05-31

    申请人： Brett Bouma ,  Guillermo Tearney ,  Dvir Yelin ,  Seok-Hyun Yun

    发明人： Brett Bouma ,  Guillermo Tearney ,  Dvir Yelin ,  Seok-Hyun Yun

    IPC分类号： A61B5/05

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/7257

    摘要： Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.

    摘要翻译： 提供了用于获得三维成像数据的系统，布置和方法。 例如，宽带光源可以提供特定的辐射。 可以将第一电磁辐射聚焦和衍射，然后提供给至少一个样品以产生光谱编码的线。 可以将第二电磁辐射提供给参考，其可以包括双遍快速扫描光学延迟，其中第一和第二电磁辐射可以基于特定辐射。 可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。 光谱编码的线可以在大致垂直于线的方向上扫描样品。 然后可以基于干扰获得包含三维信息的图像数据。 示例性的成像方法和系统可以用于小型光纤或内窥镜探针。

    SYSTEMS AND METHODS FOR GENERATING DATA BASED ON ONE OR MORE SPECTRALLY-ENCODED ENDOSCOPY TECHNIQUES
    5.
    发明申请
    SYSTEMS AND METHODS FOR GENERATING DATA BASED ON ONE OR MORE SPECTRALLY-ENCODED ENDOSCOPY TECHNIQUES 有权
    基于一种或多种频谱编码的内窥镜技术生成数据的系统和方法

    公开(公告)号：US20070263208A1

    公开(公告)日：2007-11-15

    申请号：US11621694

    申请日：2007-01-10

    申请人： Dvir Yelin ,  Seok-Hyun Yun ,  Brett Bouma ,  Guillermo Tearney

    发明人： Dvir Yelin ,  Seok-Hyun Yun ,  Brett Bouma ,  Guillermo Tearney

    IPC分类号： G01J3/36 ,  G06F17/14

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/6852 ,  A61B5/7257 ,  A61B5/726 ,  G01B9/02002 ,  G01B9/02036 ,  G01B9/02037 ,  G01B9/02044 ,  G01B9/02091 ,  G01N21/359 ,  G01N2021/1782 ,  G01N2021/1787 ,  G01N2021/3595

    摘要： Exemplary systems and methods for generating data associated with at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to provide a particular radiation using at least one first arrangement. The particular radiation can include at least one first electro-magnetic radiation directed to at least one sample and at least one second electro-magnetic radiation directed to a reference arrangement. The first radiation and/or the second radiation can comprise a plurality of wavelengths. The first electro-magnetic radiation can be spectrally dispersed along at least one portion of the sample. The second electro-magnetic radiation measured at two or more different lengths of the reference arrangement with respect to the first arrangement. Data can be generated which is associated with the first and second electro-magnetic radiations obtained at the two different lengths using at least one second arrangement which comprises a spectrometer arrangement.

    摘要翻译： 可以提供用于产生与样品的至少一部分相关联的数据的示例性系统和方法。 例如，根据这样的系统和方法的一个示例性实施例，可以使用至少一个第一布置来提供特定的辐射。 特定的辐射可以包括被引导至至少一个样品的至少一个第一电磁辐射和指向参考装置的至少一个第二电磁辐射。 第一辐射和/或第二辐射可以包括多个波长。 第一电磁辐射可沿样品的至少一部分光谱分散。 在参考装置的两个或多个不同长度处相对于第一装置测量的第二电磁辐射。 可以生成与使用包括光谱仪布置的至少一个第二布置在两个不同长度获得的第一和第二电磁辐射相关联的数据。