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    TREATMENT FOR DARK ADAPTATION
    2.
    发明申请
    TREATMENT FOR DARK ADAPTATION 审中-公开
    治疗深度适应

    公开(公告)号：US20100047330A1

    公开(公告)日：2010-02-25

    申请号：US12245944

    申请日：2008-10-06

    申请人： Daniel M. Schwartz ,  Keith G. Duncan ,  Kathy R. Bailey ,  John P. Kane ,  Brian Y. Ishida

    发明人： Daniel M. Schwartz ,  Keith G. Duncan ,  Kathy R. Bailey ,  John P. Kane ,  Brian Y. Ishida

    IPC分类号： A61K9/127 ,  A61K38/17 ,  A61P27/02

    CPC分类号： A61K31/685 ,  A61K31/66 ,  A61K38/17 ,  A61K38/1709 ,  A61K2300/00

    摘要： The present invention addresses the treatment of age-related macular degeneration using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, compositions that increase reverse cholesterol transport are utilized as therapeutic targets for age-related macular degeneration. In a specific embodiment, the lipid content of the retinal pigment epithelium, and/or Bruch's membrane is reduced by delivering Apolipoprotein A1, particularly a mimetic peptide.

    摘要翻译： 本发明通过调节与动脉粥样硬化相似的致病机制来解决年龄相关性黄斑变性的治疗。 在另外的具体实施方案中，增加反向胆固醇转运的组合物被用作年龄相关性黄斑变性的治疗靶标。 在一个具体的实施方案中，通过递送载脂蛋白A1，特别是模拟肽来减少视网膜色素上皮和/或Bruch's膜的脂质含量。

    Treatment for dark adaptation
    3.
    发明授权
    Treatment for dark adaptation 失效
    治疗黑暗适应

    公开(公告)号：US07470660B2

    公开(公告)日：2008-12-30

    申请号：US11055309

    申请日：2005-02-10

    申请人： Daniel M. Schwartz ,  Keith G. Duncan ,  Kathy Bailey ,  John P. Kane ,  Brian Y. Ishida

    发明人： Daniel M. Schwartz ,  Keith G. Duncan ,  Kathy Bailey ,  John P. Kane ,  Brian Y. Ishida

    IPC分类号： A61K31/685 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/10 ,  A61K38/17

    CPC分类号： A61K31/685 ,  A61K31/66 ,  A61K38/17 ,  A61K38/1709 ,  A61K2300/00

    摘要： The present invention addresses the treatment of age-related macular degeneration, and treatment of individuals with impaired visual function such as impaired dark adaptation, using regulation of pathogenic mechanisms similar to atherosclerosis. In further specific embodiments, compositions that increase reverse cholesterol transport are utilized as therapeutic targets for age-related macular degeneration and improving impaired dark adaptation. In a specific embodiment, the lipid content of the retinal pigment epithelium, and/or Bruch's membrane is reduced by delivering Apolipoprotein A1, particularly a mimetic peptide.

    摘要翻译： 本发明涉及使用与动脉粥样硬化相似的致病机制的调节来处理年龄相关性黄斑变性和视力功能受损的个体的治疗，例如暗适应受损。 在进一步的具体实施方案中，增加反向胆固醇转运的组合物被用作年龄相关性黄斑变性和改善受损的黑暗适应的治疗靶标。 在一个具体的实施方案中，通过递送载脂蛋白A1，特别是模拟肽来减少视网膜色素上皮和/或Bruch's膜的脂质含量。

    System and method for managing virtual machines
    4.
    发明授权
    System and method for managing virtual machines 有权
    用于管理虚拟机的系统和方法

    公开(公告)号：US08578374B2

    公开(公告)日：2013-11-05

    申请号：US12504297

    申请日：2009-07-16

    申请人： John P. Kane

    发明人： John P. Kane

    IPC分类号： G06F9/455 ,  G06F9/46 ,  G06F7/04

    CPC分类号： G06F9/45558 ,  G06F2009/45575 ,  G06F2009/45587

    摘要： In some embodiments, a method for virtual machine management includes receiving a request for a first virtual machine from a virtual host. The method also includes comparing the request for the first virtual machine to a policy. The policy includes rules that govern access to a plurality of virtual machines. In addition, the method includes providing the virtual host access to a second virtual machine in response to comparing the request for the first virtual machine to the policy.

    摘要翻译： 在一些实施例中，用于虚拟机管理的方法包括从虚拟主机接收对第一虚拟机的请求。 该方法还包括将第一虚拟机的请求与策略进行比较。 该策略包括管理对多个虚拟机的访问的规则。 此外，该方法包括提供对第二虚拟机的虚拟主机访问以响应于将第一虚拟机的请求与策略进行比较。

    Auxiliary tire bead depressor
    7.
    发明授权
    Auxiliary tire bead depressor 失效
    辅助轮胎胎压抑制器

    公开(公告)号：US5072765A

    公开(公告)日：1991-12-17

    申请号：US605547

    申请日：1990-10-30

    申请人： John P. Kane ,  Francis H. Goodman

    发明人： John P. Kane ,  Francis H. Goodman

    IPC分类号： B60C25/12 ,  B60C25/14

    CPC分类号： B60C25/145

    摘要： An auxiliary tire bead depressor is provided for use with an apparatus for inflating a tubeless tire having sidewalls and upper and lower annular tire beads. The tire is mounted on a wheel having upper and lower wheel flanges against which the upper and lower tire beads seal, respectively. The apparatus has an inflation head and an annular tire seal ring extending outwardly therefrom for depressing the tire sidewall. The auxiliary tire bead depressor comprises a mechanism, spaced from the annular tire seal ring, for selectively depressing the upper tire bead away from the upper wheel flange. The tire bead depressing mechanism is moved from an advanced position wherein the depressing mechanism engages and depresses the tire, to a retracted position wherein the depressing mechanism is spaced from the tire. The auxiliary tire bead depressor is mounted to the inflation head.

    摘要翻译： 提供了一种辅助轮胎胎压抑制器，用于充气具有侧壁和上下环形轮胎胎圈的无内胎轮胎的装置。 轮胎安装在具有上和下轮缘的车轮上，上轮胎胎圈和下轮胎胎圈分别与胎圈密封。 该装置具有从其向外延伸的膨胀头和环形轮胎密封环，用于压下轮胎侧壁。 辅助轮胎胎压抑制器包括与环形轮胎密封环间隔开的机构，用于选择性地将上轮胎胎圈远离上轮胎凸缘压下。 轮胎胎压按压机构从其中下压机构接合并压下轮胎的前进位置移动到缩回位置，其中按压机构与轮胎间隔开。 辅助轮胎胎压抑制器安装到充气头。

    Pharmaceutical microemulsions
    8.
    发明授权
    Pharmaceutical microemulsions 失效
    药物微乳

    公开(公告)号：US5023271A

    公开(公告)日：1991-06-11

    申请号：US765359

    申请日：1985-08-13

    申请人： Jean-Louis Vigne ,  John P. Kane

    发明人： Jean-Louis Vigne ,  John P. Kane

    IPC分类号： A61K9/107

    CPC分类号： A61K9/1075

    摘要： A method for parenteral administration of fat-soluble pharmaceuticals and vitamins using microemulsions is disclosed. The microemulsions are comprised of a naturally occurring amphipatic substance and a hydrophobic lipid along with the active ingredient, are size selected for 300-1000 .ANG. pseudomicelles, and permit safe intravenous injection of the active ingredient. Levels of the active ingredient in the various lipoprotein fractions of serum appear to mimic the natural distribution of the administered drug if taken orally.

    摘要翻译： 公开了一种使用微乳液肠胃外给药脂溶性药物和维生素的方法。 微乳液由天然存在的两亲物质和疏水性脂质以及活性成分组成，其尺寸选择为300-1000个ANGSTROM假胶束，并允许安全地静脉内注射活性成分。 血清各种脂蛋白级分中活性成分的含量似乎模拟了口服给药的药物的天然分布。

    Proximity switch mounting apparatus
    9.
    发明授权
    Proximity switch mounting apparatus 失效
    接近开关安装装置

    公开(公告)号：US4752657A

    公开(公告)日：1988-06-21

    申请号：US46793

    申请日：1987-05-07

    申请人： John P. Kane ,  Billy Davenport ,  Ray Sidelinker

    发明人： John P. Kane ,  Billy Davenport ,  Ray Sidelinker

    IPC分类号： F15B15/28 ,  H01H1/58 ,  H01H3/60 ,  H01H9/02 ,  H01H36/00 ,  H01H35/38

    CPC分类号： F15B15/2892 ,  H01H36/0033 ,  H01H1/58 ,  H01H3/60 ,  H01H36/0046 ,  H01H9/0207

    摘要： A mounting apparatus for a proximity switch for sensing the position of a piston within a fluid operated, expandable chamber cylinder. The mounting device comprises a block shaped member with at least a first depressed, arcuate surface, the degree of curvature of which is adapted to fit the surface of the cylinder. By first attaching the mounting apparatus to the proximity switch and then positioning the proximity switch with respect to the fluid cylinder, tightening down of fastening devices provided for the proximity switch will cause the arcuate surface to firmly engage the surface of the cylinder, thereby providing a secure, vibration resistant mounting of the proximity switch to the cylinder.

    摘要翻译： 一种用于接近开关的安装装置，用于感测活塞在流体操作的可膨胀腔室气缸内的位置。 安装装置包括具有至少第一凹陷的弓形表面的块状构件，其曲率适合于装配气缸的表面。 通过首先将安装装置附接到接近开关，然后将接近开关相对于流体缸定位，为靠近开关设置的紧固装置的紧固将使得弓形表面牢固地接合气缸的表面，由此提供 将接近开关固定，防震安装到气缸。

    Multi-component and mixed-reality simulation environments
    10.
    发明授权
    Multi-component and mixed-reality simulation environments 有权

    公开(公告)号：US10311171B2

    公开(公告)日：2019-06-04

    申请号：US14636134

    申请日：2015-03-02

    申请人： Steven L. Greenspan ,  Debra J. Danielson ,  James D. Reno ,  John P. Kane ,  Prashant Parikh

    发明人： Steven L. Greenspan ,  Debra J. Danielson ,  James D. Reno ,  John P. Kane ,  Prashant Parikh

    IPC分类号： H04W4/70 ,  G06F17/50

    摘要： Systems and methods may include receiving real-time data about a real component operating in a real-world environment. The systems and methods may further include generating a virtual representation of the real component based on the real-time data about the real component and historical data associated with the real component. In addition, the systems and methods may include receiving injected data from a lab. The injected data may provide data about a lab component operating in the lab. The systems and methods may also include simulating, in a virtual environment, a real-time interaction in the real-world environment between the real component and the lab component using the virtual representation of the real component and the injected data. Moreover, the systems and methods may include determining a real-time performance characteristic of at least one of the lab component and the real component based on the simulated real-time interaction in the real-world environment.