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公开(公告)号：US08940849B2
公开(公告)日：2015-01-27
申请号：US13792832
申请日：2013-03-11
Applicant: The Goodyear Tire & Rubber Company , Danisco US Inc.
Inventor： Frank J. Feher , Gregory M. Whited , Gopal K. Chotani , Fernando Valle , Carol Fioresi , Karl J. Sanford , Joseph McAuliffe , Marguerite Cervin , Aaron S. Puhala , Andrei Miasnikov , Ilana S. Aldor
IPC: C08F297/04 , C08F136/08 , C08F236/08 , C07C11/18 , C08F2/00 , C08F36/04 , C08L9/00 , C12P5/00 , C08F236/10 , C12P5/02 , C08F4/48
CPC classification number: C08F236/18 , C08F2/00 , C08F36/04 , C08F136/08 , C08F236/08 , C08F236/10 , C08F236/12 , C08L9/00 , C12P5/007 , Y10T436/24
Abstract: It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has δ13C value of greater than −22‰.
Abstract translation: 已经发现，培养物中的某些细胞可将大于约0.002％的细胞培养基中可用的碳转化为异戊二烯。 这些细胞具有异源核酸，其（i）编码异戊二烯合酶多肽，和（ii）可操作地连接于启动子。 然后可以回收在这种培养基中产生的异戊二烯并聚合成合成橡胶和其它有用的聚合物材料。 本发明的合成含异戊二烯的聚合物提供可证实为从非石化基础资源得到的益处。 它们也可以分析与来自天然来源的橡胶。 本发明更具体地公开了由衍生自异戊二烯单体的重复单元组成的聚异戊二烯聚合物，其中聚异戊二烯聚合物的δ13C值大于-22‰。
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公开(公告)号：US10774345B2
公开(公告)日：2020-09-15
申请号：US15677335
申请日：2017-08-15
Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
Inventor： Anthony R. Calabria , Marguerite A. Cervin , Gopal K. Chotani , Richard La Duca , Joseph C. McAuliffe , Michael C. Miller , Timothy A. Sabo , Karl J. Sanford , Erin. L. Spring , Gregory M. Whited
IPC: C12P5/02 , C12P5/00 , C12N15/52 , C07C11/18 , C12N9/88 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80
Abstract: The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
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公开(公告)号：US20170183691A1
公开(公告)日：2017-06-29
申请号：US15305036
申请日：2015-04-06
Applicant: Danisco US Inc.
Inventor： Kathleen A. Clarkson , Matthew T. Reboli , Jacquelyn A. Huitink , Paula Johanna Maria Teunissen , Gopal K. Chotani , Jayarama K. Shetty
IPC: C12P7/14
Abstract: A conversion process provides using different co-cultured cell lines to express different sets of enzymes catalyzing the same process. For example, in a Simultaneous Saccharification and Co-Fermentation (SSCF) process, a starch substrate is converted to alcohol by contacting the substrate with yeast and Aspergillus niger cells. Because A. niger expresses an endogenous glucoamylase and alpha-amylase, these enzymes do not need to be added during the SSCF process.
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4.发明授权Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids 有权直接淀粉可发酵糖作为生产异戊二烯，类异戊二烯前体分子和/或类异戊二烯的原料公开(公告)号：US09315831B2
公开(公告)日：2016-04-19
申请号：US13802420
申请日：2013-03-13
Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
Inventor： Collette M. Blake , Gopal K. Chotani , Gang Duan , Douglas Ko , Floor Kooy , Sung Ho Lee , Michael J. Pepsin , Ying Qian , Matt Reboli , Vivek Sharma , Jayarama K. Shetty , Bruce A. Strohm , Pauline Johanna Maria Teunissen , Hongxian Xu
CPC classification number: C12P5/007 , C12N9/88 , C12P7/42 , C12P7/46 , C12P7/56 , C12P19/02 , C12P19/14 , C12Y301/03 , Y02P20/52
Abstract: Provided herein are compositions and methods related to the direct conversion of the starch in a ground or fractionated grain into a fermentable sugar feedstock capable of serving as a carbon source for the industrial production of one or more products by a fermenting organism, such as isoprene, isoprenoid precursor molecules, and/or isoprenoids. Such conversions may be performed at temperatures at or below the initial gelatinization temperature of the starch present in the grain and may utilize one or more isolatable endogenous enzymes present in certain unrefined grains.
Abstract translation: 本文提供的组合物和方法与将研磨的或分级的颗粒中的淀粉直接转化成能够通过发酵生物体如异戊二烯工业生产一种或多种产物的碳源的可发酵糖原料有关， 类异戊二烯前体分子和/或类异戊二烯。 这样的转化可以在等于或低于晶粒中存在的淀粉的初始糊化温度的温度下进行，并且可以利用存在于某些未精制谷物中的一种或多种可分离的内源性酶。
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5.发明申请EXPRESSION OF GRANULAR STARCH HYDROLYZING ENZYMES IN TRICHODERMA AND PROCESS FOR PRODUCING GLUCOSE FROM GRANULAR STARCH SUSTRATES 有权三倍体中颗粒淀粉酶水解酶的表达及从颗粒淀粉辅助制备葡萄糖的方法公开(公告)号：US20150284756A1
公开(公告)日：2015-10-08
申请号：US14688283
申请日：2015-04-16
Applicant: Danisco US Inc.
Inventor： Toby M. Baldwin , Benjamin S. Bower , Gopal K. Chotani , Nigel Dunn-Coleman , Oreste J. Lantero , Suzanne Lantz , Michael J. Pepsin , Jayarama K. Shetty , Bruce A. Strohm
CPC classification number: C12P19/14 , C12N1/14 , C12N9/242 , C12N9/2428 , C12P19/02 , C12P19/04 , C12P19/20 , C12P19/24 , Y02E50/17 , Y02P20/52
Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular starch substrate simultaneously with an alpha amylase and a GSHE at a temperature equal to or below the gelatinization temperature of the granular starch to obtain a composition of a glucose syrup.
Abstract translation: 本发明涉及丝状真菌宿主细胞，特别涉及可用于生产具有葡糖淀粉酶活性的异源粒状淀粉水解酶（GSHE）的木霉宿主细胞。 此外，本发明涉及一种葡萄糖浆的制造方法，其特征在于，使粒状淀粉底物获得的粒状淀粉浆料与α淀粉酶和GSHE同时等于或低于所述粒状淀粉的凝胶化温度，得到组合物 的葡萄糖浆。
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Patent Agency Ranking
公开(公告)号：US09121039B2
公开(公告)日：2015-09-01
申请号：US14028342
申请日：2013-09-16
Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
Inventor： Gopal K. Chotani , Joseph C. McAuliffe , Caroline M. Peres , Gregory M. Whited
Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity. Additionally, the invention provides methods of producing isoprene by culturing cells under conditions suitable for isoprene production while maintaining cell viability and/or metabolic activity.
Abstract translation: 本发明的特征在于从培养细胞产生异戊二烯的方法。 本发明还提供包括这些培养细胞的组合物。 本发明提供异戊二烯组合物，例如具有增加的异戊二烯量或增加的纯度的组合物。 另外，本发明提供了通过在适合异戊二烯生产的条件下培养细胞同时维持细胞活力和/或代谢活性来生产异戊二烯的方法。
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公开(公告)号：US20130253141A1
公开(公告)日：2013-09-26
申请号：US13792832
申请日：2013-03-11
Applicant: THE GOODYEAR TIRE & RUBBER COMPANY , DANISCO US INC.
Inventor： Frank J. Feher , Gregory M. Whited , Gopal K. Chotani , Fernando Valle , Carol Fioresi , Karl J. Sanford , Joseph McAuliffe , Marguerite Cervin , Aaron S. Puhala , Andrei Miasnikov , Ilana S. Aldor
IPC: C08F136/08 , C08F236/10 , C08F236/08
CPC classification number: C08F236/18 , C08F2/00 , C08F36/04 , C08F136/08 , C08F236/08 , C08F236/10 , C08F236/12 , C08L9/00 , C12P5/007 , Y10T436/24
Abstract: It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has δ13C value of greater than −22‰.
Abstract translation: 已经发现，培养物中的某些细胞可将大于约0.002％的细胞培养基中可用的碳转化为异戊二烯。 这些细胞具有异源核酸，其（i）编码异戊二烯合酶多肽，和（ii）可操作地连接于启动子。 然后可以回收在这种培养基中产生的异戊二烯并聚合成合成橡胶和其它有用的聚合物材料。 本发明的合成含异戊二烯的聚合物提供可证实为从非石化基础资源得到的益处。 它们也可以分析与来自天然来源的橡胶。 本发明更具体地公开了由衍生自异戊二烯单体的重复单元组成的聚异戊二烯聚合物，其中聚异戊二烯聚合物的δ13C值大于-220 / 00。
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8.发明申请Expression of Granular Starch Hydrolyzing Enzymes in Trichoderma and Process for Producing Glucose from Granular Starch Sustrates 审中-公开颗粒状淀粉水解酶在木霉中的表达及从颗粒状淀粉苏糖中生产葡萄糖的方法公开(公告)号：US20130122569A1
公开(公告)日：2013-05-16
申请号：US13664216
申请日：2012-10-30
Applicant: Danisco US Inc.
Inventor： Toby M. Baldwin , Benjamin S. Bower , Gopal K. Chotani , Nigel Dunn-Coleman , Oreste J. Lantero, JR. , Suzanne Lantz , Michael J. Pepsin , Jayarama K. Shetty , Bruce A. Strohm
IPC: C12N9/24
CPC classification number: C12P19/14 , C12N1/14 , C12N9/242 , C12N9/2428 , C12P19/02 , C12P19/04 , C12P19/20 , C12P19/24 , Y02E50/17 , Y02P20/52
Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular starch substrate simultaneously with an alpha amylase and a GSHE at a temperature equal to or below the gelatinization temperature of the granular starch to obtain a composition of a glucose syrup.
Abstract translation: 本发明涉及丝状真菌宿主细胞，特别涉及可用于生产具有葡糖淀粉酶活性的异源粒状淀粉水解酶（GSHE）的木霉宿主细胞。 此外，本发明涉及一种葡萄糖浆的制造方法，其特征在于，使粒状淀粉底物获得的粒状淀粉浆料与α淀粉酶和GSHE同时等于或低于所述粒状淀粉的凝胶化温度，得到组合物 的葡萄糖浆。
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公开(公告)号：US09909144B2
公开(公告)日：2018-03-06
申请号：US14987681
申请日：2016-01-04
Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
Inventor： Marguerite A. Cervin , Gopal K. Chotani , Frank J. Feher , Richard La Duca , Joseph C. McAuliffe , Andrei Miasnikov , Caroline M. Peres , Aaron S. Puhala , Karl J. Sanford , Fernando Valle , Gregory M. Whited
IPC: C12N1/20 , C12N1/00 , C12N15/00 , C12P5/02 , C07H21/04 , C12P5/00 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90 , C12N15/52
CPC classification number: C12P5/007 , C12N9/1022 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y203/01009 , C12Y207/01036 , C12Y401/01033 , C12Y402/03027 , C12Y503/03002 , Y02E50/343
Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
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公开(公告)号：US09777294B2
公开(公告)日：2017-10-03
申请号：US14973485
申请日：2015-12-17
Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
Inventor： Anthony R. Calabria , Marguerite A. Cervin , Gopal K. Chotani , Richard La Duca , Joseph C. McAuliffe , Michael C. Miller , Timothy A. Sabo , Karl J. Sanford , Erin L. Spring , Gregory M. Whited
IPC: C12P5/02 , C12P5/00 , C12N15/52 , C07C11/18 , C12N9/88 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80
CPC classification number: C12P5/007 , C07C11/18 , C12N9/88 , C12N15/52 , C12N15/70 , C12N15/74 , C12N15/75 , C12N15/80 , C12P5/02 , C12Y402/03027 , Y02E50/343
Abstract: The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
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