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公开(公告)号：US07091204B2
公开(公告)日：2006-08-15
申请号：US10477067
申请日：2002-05-07
IPC分类号： A61K31/404 , A61K31/495 , C07D239/02 , C07D207/04
CPC分类号： C07D207/12 , C07D333/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
摘要翻译： 本发明涉及磺酰胺，含有它们的药物组合物，以及它们作为尿素调节素II拮抗剂的用途。
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公开(公告)号：US06849635B2
公开(公告)日：2005-02-01
申请号：US10477053
申请日：2002-05-07
IPC分类号： C07D317/50 , A61K31/18 , A61K31/277 , A61K31/36 , A61K31/381 , A61K31/506 , A61P1/00 , A61P1/04 , A61P3/06 , A61P3/10 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/00 , A61P15/10 , A61P19/00 , A61P19/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P43/00 , C07C311/14 , C07C311/21 , C07C311/29 , C07D333/34 , C07D409/04 , A61K31/275 , A61K31/38
CPC分类号： C07D409/04 , C07C311/14 , C07C311/29 , C07D333/34
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
摘要翻译： 本发明涉及磺酰胺，含有它们的药物组合物，以及它们作为尿素调节素II的拮抗剂的用途。
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公开(公告)号：US07026349B2
公开(公告)日：2006-04-11
申请号：US10477068
申请日：2002-05-07
IPC分类号： A61K31/40 , C07D207/12
CPC分类号： C07D207/12 , C07D333/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
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公开(公告)号：US20120283287A1
公开(公告)日：2012-11-08
申请号：US13442688
申请日：2012-04-09
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US08207340B2
公开(公告)日：2012-06-26
申请号：US12350094
申请日：2009-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： C07D471/02 , A61K31/47
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US07618981B2
公开(公告)日：2009-11-17
申请号：US11121709
申请日：2005-05-03
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： C07D471/02 , A61K31/4439
CPC分类号： C07D403/12 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D233/62 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D471/04 , C07F9/6506 , C07F9/6561
摘要： Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要翻译： 提供式V的化合物及其药学上可接受的盐，其可用于治疗癌症或其它增殖性疾病。
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公开(公告)号：US07582668B2
公开(公告)日：2009-09-01
申请号：US11598250
申请日：2006-11-08
申请人： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/4178 , C07D403/10
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要翻译： 提供了可用于治疗癌症或其它增殖性疾病的式I化合物及其药学上可接受的盐。
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公开(公告)号：US20080255182A1
公开(公告)日：2008-10-16
申请号：US12007143
申请日：2008-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US07019008B2
公开(公告)日：2006-03-28
申请号：US11119026
申请日：2005-04-29
IPC分类号： A61K31/496 , C07D409/14
CPC分类号： C07D409/12
摘要： A compound of Formula (I): wherein: R1 is C1-6 alkyl, benzyl, or (CH2)n—C(O)NH2; wherein the benzyl may be unsubstituted or substituted by one or two C1-6 alkyl, halogen, C1-6 alkoxy, or methylenedioxy groups; R2 is benzimidazolyl, quinolinyl, benzofuranyl, napthyl, indolyl, benzothiophenyl, phenyl, furanyl, thienyl, or pyridyl substituted or unsubstituted by one, two or three halogen, C1-3 alkyl, C1-3 alkoxy, or methylenedioxy groups; X1 and X2 are independently hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, nitro, CF3, or CN; n is 1, 2, or 3; m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.
摘要翻译： 式（I）的化合物：其中：R 1是C 1-6烷基，苄基或（CH 2 CH 2） -C（O）NH 2; 其中苄基可以是未取代的或被一个或两个C 1-6烷基，卤素，C 1-6烷氧基或亚甲二氧基取代; R 2是苯并咪唑基，喹啉基，苯并呋喃基，萘基，吲哚基，苯并噻吩基，苯基，呋喃基，噻吩基或被1,2或3个卤素取代或未取代的吡啶基， 亚烷基，C 1-3烷氧基或亚甲二氧基; X 1和X 2独立地是氢，卤素，C 1-3烷基，C 1-3烷氧基 ，硝基，CF 3或CN; n为1,2或3; m为1,2或3; 或其药学上可接受的盐。
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公开(公告)号：US07795448B2
公开(公告)日：2010-09-14
申请号：US11124608
申请日：2005-05-06
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： C07D233/64 , C07D231/12 , A61K31/415 , A61K31/4164
CPC分类号： C07D403/12 , A61K31/4172 , A61K31/421 , A61K31/426 , A61K31/4745 , A61K31/538 , A61K31/66 , A61K45/06 , C07C235/48 , C07C235/50 , C07C237/22 , C07C255/44 , C07C255/57 , C07C255/60 , C07C271/28 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D231/12 , C07D235/18 , C07D239/22 , C07D261/08 , C07D271/06 , C07D277/42 , C07D285/12 , C07D295/15 , C07D333/38 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要翻译： 提供式V的化合物及其药学上可接受的盐，其可用于治疗癌症或其它增殖性疾病。
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