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公开(公告)号：US09669091B2
公开(公告)日：2017-06-06
申请号：US14775087
申请日：2014-03-13
申请人： David B. Weiner , Jian Yan , Matthew Morrow , Bernadette Ferraro , David Hokey
发明人： David B. Weiner , Jian Yan , Matthew Morrow , Bernadette Ferraro , David Hokey
IPC分类号： C12P21/02 , C12N15/03 , A61K39/39 , C07K14/54 , A61K9/00 , A61K39/015 , A61K39/12 , C12N7/00 , C12P21/00 , C12N15/09 , C12N15/10 , A61K39/00
CPC分类号： A61K39/39 , A61K9/0009 , A61K39/015 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/55527 , C07K14/54 , C12N7/00 , C12N15/03 , C12N2710/20033 , C12N2710/20034 , C12P21/02 , Y02A50/412
摘要： Disclosed herein is a vaccine comprising an antigen and IL-23. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
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2.发明申请FOOT AND MOUTH DISEASE VIRUS (FMDV) CONSENSUS PROTEINS, CODING SEQUENCES THEREFOR AND VACCINES MADE THEREFROM 有权FOOD和MOUD疾病病毒（FMDV）共识蛋白，其编码序列及其制备的疫苗公开(公告)号：US20120282217A1
公开(公告)日：2012-11-08
申请号：US13503828
申请日：2010-11-02
申请人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
发明人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
IPC分类号： A61K39/135 , C12N15/62 , C12N15/57 , C12N15/63 , A61M37/00 , C07K14/09 , C07K19/00 , C12N9/50 , C12Q1/70 , G01N33/569 , C12N15/42 , A61K38/20
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译： 本文提供的是包含FMDV亚型A，亚洲1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP1-4外壳蛋白的共有氨基酸序列的核酸，以及表达 序列。 本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法以及用疫苗接种的哺乳动物和用FMDV感染的哺乳动物之间进行解密的方法。
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3.发明申请CONSENSUS ANTIGEN CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING THE SAME TO TREAT MALARIA 审中-公开共同抗原构建物及其制备方法及其使用方法治疗疟疾公开(公告)号：US20130273112A1
公开(公告)日：2013-10-17
申请号：US13876148
申请日：2011-09-27
IPC分类号： A61K39/015 , A61K38/20
摘要： Provided herein is consensus amino acid sequences of P. falciparum (P.f.) proteins and their encoding sequences, as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against P. falciparum using the expression constructs provided herein.
摘要翻译： 本文提供恶性疟原虫（P.f.）蛋白及其编码序列的共有氨基酸序列以及表达序列的表达构建体。 本文还提供了使用本文提供的表达构建体来产生针对恶性疟原虫的免疫应答的方法。
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公开(公告)号：US10799572B2
公开(公告)日：2020-10-13
申请号：US13876148
申请日：2011-09-27
IPC分类号： A61K39/015 , C07K14/445 , A61K38/19 , A61K38/20 , A61K39/00
摘要： Provided herein is consensus amino acid sequences of P. falciparum (P.f.) proteins and their encoding sequences, as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against P. falciparum using the expression constructs provided herein.
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5.发明申请CONSENSUS PROSTATE ANTIGENS, NUCLEIC ACID MOLECULE ENCODING THE SAME AND VACCINE AND USES COMPRISING THE SAME 有权共识前列腺抗原，编码其的核酸分子和疫苗，并使用它们公开(公告)号：US20130302361A1
公开(公告)日：2013-11-14
申请号：US13883978
申请日：2011-11-14
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/485 , C12N9/6424 , C12Y116/01 , C12Y304/17021 , C12Y304/21077
摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
摘要翻译： 本文提供了能够在目标物种（包括PSA，PSMA，STEAP和PSCA抗原）中破坏耐受性的前列腺抗原的共有氨基酸序列。 还提供编码前列腺抗原PSA，PSMA，STEAP和PSCA的一个或多个共有氨基酸序列的核酸序列，以及表达序列的遗传构建体/载体和疫苗。 本文还提供了通过施用提供的一种或多种疫苗，蛋白质和/或核酸序列来产生针对前列腺癌细胞的自身免疫应答的方法。
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公开(公告)号：US10022434B2
公开(公告)日：2018-07-17
申请号：US14774241
申请日：2014-03-12
申请人： David B. Weiner , Jian Yan , Matthew Morrow
发明人： David B. Weiner , Jian Yan , Matthew Morrow
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
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公开(公告)号：US11851477B2
公开(公告)日：2023-12-26
申请号：US16098921
申请日：2017-05-05
申请人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
发明人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
CPC分类号： C07K16/1018 , A61P31/16 , A61K2039/505 , A61K2039/545 , C07K16/248 , C07K16/2866 , C07K2317/76
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.
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公开(公告)号：US20190135899A1
公开(公告)日：2019-05-09
申请号：US16098921
申请日：2017-05-05
申请人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
发明人： David B. Weiner , Ami Patel , Jian Yan , Sarah Elliott
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.
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9.发明授权Nucleic acid molecule encoding hepatitis B virus core protein and vaccine comprising the same 有权编码乙型肝炎病毒核心蛋白的核酸分子和包含其的疫苗公开(公告)号：US09403879B2
公开(公告)日：2016-08-02
申请号：US13984771
申请日：2012-02-13
申请人： David B. Weiner , Jian Yan , Nyamekye Obeng-Adjei
发明人： David B. Weiner , Jian Yan , Nyamekye Obeng-Adjei
CPC分类号： A61K39/292 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/57 , A61K2039/572 , C07K14/005 , C07K14/02 , C12N7/00 , C12N2730/10134 , C12N2730/10171
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequence of HBV core protein, as well as genetic constructs/vectors and vaccines that express said protein sequences. Also provided herein are methods for generating an immune response against HBV using the nucleic acid sequences that are provided.
摘要翻译： 本文提供了编码HBV核心蛋白的新的共有氨基酸序列的核酸序列，以及表达所述蛋白质序列的遗传构建体/载体和疫苗。 本文还提供了使用提供的核酸序列产生针对HBV的免疫应答的方法。
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公开(公告)号：US20110182938A1
公开(公告)日：2011-07-28
申请号：US12694238
申请日：2010-01-26
申请人： David B. Weiner , Jian Yan , Matthew P. Morrow
发明人： David B. Weiner , Jian Yan , Matthew P. Morrow
IPC分类号： A61K39/145 , C07H21/04 , C12N15/63 , A61K31/7088 , A61K39/00
CPC分类号： A61K39/145 , A61K31/7088 , A61K39/12 , A61K45/06 , A61K2039/53 , A61K2039/54 , C12N2760/16134
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotypes using the vaccines that are provided.
摘要翻译： 本文提供了编码HA血凝素的新的共有氨基酸序列以及表达序列的遗传构建体/载体和疫苗的核酸序列。 本文还提供了使用所提供的疫苗产生针对一种或多种流感A血清型的免疫应答的方法。
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