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    COMPRESSION ASSEMBLY
    2.
    发明申请
    COMPRESSION ASSEMBLY 审中-公开
    压缩装配

    公开(公告)号：US20130085428A1

    公开(公告)日：2013-04-04

    申请号：US13249338

    申请日：2011-09-30

    申请人： Manish Deshpande

    发明人： Manish Deshpande

    IPC分类号： A61H7/00

    CPC分类号： A61H9/0092 ,  A61H2201/0107 ,  A61H2201/0192 ,  A61H2201/165 ,  A61H2201/5002 ,  A61H2205/06 ,  A61H2205/10 ,  A61H2209/00

    摘要： A compression assembly is adapted for placement on a body part for imparting compression therapy to the body part. The compression assembly includes a bladder and a bladder support. The bladder support and bladder have corresponding connection structure for mounting the bladder on the bladder support. In certain embodiments, the bladder is held in tension when mounted on the bladder support. In certain embodiments, the bladder support includes protrusions adapted for push-in reception in openings on the bladder for mounting the bladder on the bladder support, the bladder support is adjustable in length, and the bladder is foldable for adjusting the length of the bladder. Removable mounting of the bladder on the bladder support enables selective disposal of the bladders and bladder supports and interchangeability of different types of bladders with particular bladder supports.

    摘要翻译： 压缩组件适于放置在身体部分上以对身体部分进行压缩治疗。 压缩组件包括气囊和气囊支撑件。 膀胱支架和囊具有相应的连接结构，用于将膀胱安装在膀胱支撑上。 在某些实施例中，当安装在膀胱支撑体上时，膀胱保持张力。 在某些实施例中，气囊支撑件包括适于在气囊上的开口中进行推入接收的突起，用于将气囊安装在气囊支撑件上，气囊支撑件可在长度上调节，并且气囊可折叠以调节膀胱的长度。 膀胱可拆卸地安装在膀胱支架上，可以选择性地处理膀胱和膀胱支架以及不同类型的气囊与特定膀胱支架的互换性。

    OPTICAL DETECTOR FOR A PARTICLE SORTING SYSTEM
    4.
    发明申请
    OPTICAL DETECTOR FOR A PARTICLE SORTING SYSTEM 有权
    用于颗粒分选系统的光学检测器

    公开(公告)号：US20110168871A1

    公开(公告)日：2011-07-14

    申请号：US12966654

    申请日：2010-12-13

    申请人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    发明人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G01N23/12 ,  G01J1/58 ,  H01L27/14 ,  G02B27/14

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6452 ,  G01N2015/1081

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    摘要翻译： 用于从空间通道阵列获取快速光谱的光学系统包括用于产生穿过微流体芯片或待监测通道的光束的光源，用于在相互作用之后捕获来自光源的光的一个或多个透镜或光纤 微流体通道中的颗粒或化学物质，以及一个或多个检测器。 可以包括光放大元件的检测器检测每个光信号并将光信号转换成电子信号。 每个表示光信号强度的电子信号从每个检测器传递到电子数据采集系统进行分析。 光放大元件可以包括耦合到光电二极管检测器阵列的光管阵列，多子光电管或基于多通道板的图像增强器。

    METHOD AND APPARATUS FOR SORTING PARTICLES
    5.
    发明申请
    METHOD AND APPARATUS FOR SORTING PARTICLES 审中-公开
    分离颗粒的方法和装置

    公开(公告)号：US20110005978A1

    公开(公告)日：2011-01-13

    申请号：US12821790

    申请日：2010-06-23

    申请人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    发明人： Sebastian Böhm ,  John R. Gilbert ,  Manish Deshpande

    IPC分类号： B03B5/00

    CPC分类号： G01N15/1459 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01N2015/149

    摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

    摘要翻译： 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀，用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块，其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置，以便降低误差率。

    Optical detector for a particle sorting system
    7.
    发明授权
    Optical detector for a particle sorting system 有权

    公开(公告)号：US07492522B2

    公开(公告)日：2009-02-17

    申请号：US11906621

    申请日：2007-10-03

    申请人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    发明人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G02B27/10 ,  C12M3/00 ,  G01N21/00

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6452 ,  G01N2015/1081

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    ON CHIP DILUTION SYSTEM
    8.
    发明申请
    ON CHIP DILUTION SYSTEM 审中-公开
    在芯片稀释系统

    公开(公告)号：US20080277615A1

    公开(公告)日：2008-11-13

    申请号：US12176901

    申请日：2008-07-21

    申请人： John Gilbert ,  Manish Deshpande

    发明人： John Gilbert ,  Manish Deshpande

    IPC分类号： F16K7/16 ,  B65D90/56

    CPC分类号： B01F3/088 ,  B01F13/0059 ,  B01F15/00019 ,  B01F15/00064 ,  B01F2003/0896 ,  B01L3/502738 ,  B01L2200/148 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0655 ,  B01L2400/082 ,  Y10T137/2499 ,  Y10T137/7736 ,  Y10T137/87676 ,  Y10T137/87684 ,  Y10T436/10 ,  Y10T436/25625

    摘要： An on-chip chemical compound dilution system for providing dilution of a chemical compound in a microfluidic application includes at least one sample well for providing a selected chemical compound to be diluted, a dilution well for providing a diluent for diluting the chemical compound, a network of channels for carrying the chemical compound and diluent, a first syringe pump for effecting dilution, a second syringe pump, a detector and a plurality of valves for selectively controlling the flow of liquid through the channels. The dilution system may be a multiple-stage dilution system for precisely mixing a plurality of chemical compounds in a diluent. The dilution system allows for accurate calibration to compensate for variations due to manufacturing, thereby providing precise dilution ratios. The dilution system further enables flushing to allow re-use of the system with another chemical compound.

    摘要翻译： 用于在微流体应用中提供化学化合物稀释的片上化学稀释系统包括至少一个用于提供所要稀释的化学化合物的样品孔，用于提供用于稀释化合物的稀释剂的稀释液，网络 用于运送化合物和稀释剂的通道，用于稀释的第一注射泵，第二注射器泵，检测器和用于选择性地控制通过通道的液体流动的多个阀。 稀释系统可以是用于在稀释剂中精确混合多种化合物的多级稀释系统。 稀释系统允许精确的校准来补偿由于制造造成的变化，从而提供精确的稀释比。 稀释系统还可以冲洗以允许再次使用另一种化合物的系统。

    Optical detector for a particle sorting system
    9.
    发明授权
    Optical detector for a particle sorting system 有权

    公开(公告)号：US07355699B2

    公开(公告)日：2008-04-08

    申请号：US11506522

    申请日：2006-08-18

    申请人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    发明人： John R. Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G01N21/00

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6452 ,  G01N2015/1081

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    Method and apparatus for sorting particles
    10.
    发明申请
    Method and apparatus for sorting particles 审中-公开
    颗粒分选方法和装置

    公开(公告)号：US20070065808A1

    公开(公告)日：2007-03-22

    申请号：US11603444

    申请日：2006-11-22

    申请人： Sebastian Bohm ,  John Gilbert ,  Manish Deshpande

    发明人： Sebastian Bohm ,  John Gilbert ,  Manish Deshpande

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  C12M1/34

    CPC分类号： G01N15/1459 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01N2015/149

    摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

    摘要翻译： 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀，用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块，其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置，以便降低误差率。