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公开(公告)号:US20070065808A1
公开(公告)日:2007-03-22
申请号:US11603444
申请日:2006-11-22
申请人: Sebastian Bohm , John Gilbert , Manish Deshpande
发明人: Sebastian Bohm , John Gilbert , Manish Deshpande
CPC分类号: G01N15/1459 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0487 , G01N2015/149
摘要: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
摘要翻译: 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀,用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块,其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置,以便降低误差率。
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2.
公开(公告)号:US20060278288A1
公开(公告)日:2006-12-14
申请号:US11433781
申请日:2006-05-12
申请人: John Gilbert , Sebastian Bohm , Manish Deshpande
发明人: John Gilbert , Sebastian Bohm , Manish Deshpande
IPC分类号: F15C1/04
CPC分类号: B01L3/502738 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/06 , B01L2400/0688 , B01L2400/082 , B07C5/34 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0036 , F16K99/004 , F16K99/0046 , F16K99/0048 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N2015/149 , Y10T29/49405 , Y10T137/0318 , Y10T137/0396 , Y10T137/0497 , Y10T137/2076 , Y10T137/2082 , Y10T137/2191 , Y10T137/2196 , Y10T137/2202 , Y10T137/2207 , Y10T137/2213 , Y10T137/2224 , Y10T436/143333 , Y10T436/25375
摘要: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.
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3.
公开(公告)号:US20050109410A1
公开(公告)日:2005-05-26
申请号:US11021251
申请日:2004-12-21
申请人: John Gilbert , Sebastian Bohm , Manish Deshpande
发明人: John Gilbert , Sebastian Bohm , Manish Deshpande
CPC分类号: B01L3/502738 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/06 , B01L2400/0688 , B01L2400/082 , B07C5/34 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0036 , F16K99/004 , F16K99/0046 , F16K99/0048 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N2015/149 , Y10T29/49405 , Y10T137/0318 , Y10T137/0396 , Y10T137/0497 , Y10T137/2076 , Y10T137/2082 , Y10T137/2191 , Y10T137/2196 , Y10T137/2202 , Y10T137/2207 , Y10T137/2213 , Y10T137/2224 , Y10T436/143333 , Y10T436/25375
摘要: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.
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公开(公告)号:US20060285983A1
公开(公告)日:2006-12-21
申请号:US11362411
申请日:2006-02-23
申请人: Bernard Bunner , Manish Deshpande , Sebastian Bohm , Richard Day , John Gilbert
发明人: Bernard Bunner , Manish Deshpande , Sebastian Bohm , Richard Day , John Gilbert
IPC分类号: F04B17/00
CPC分类号: F04B43/025 , F04B43/04 , F04B43/043 , Y10S977/963
摘要: An electromagnetic micropump for pumping small volumes of liquids and gases comprises a magnetic actuator assembly, a flexible membrane and a housing defining a chamber and a plurality of valves. The magnetic actuator assembly comprises a coil and a permanent magnet for deflecting the membrane to effect pumping of the fluid. A plurality of micropumps may be stacked together to increase pumping capacity.
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公开(公告)号:US20070044851A1
公开(公告)日:2007-03-01
申请号:US11591213
申请日:2006-11-01
申请人: John Gilbert , Bernard Bunner , Sebastian Bohm , Manish Deshpande
发明人: John Gilbert , Bernard Bunner , Sebastian Bohm , Manish Deshpande
IPC分类号: F16K27/00
CPC分类号: F16K99/0001 , F15C5/00 , F16K99/0005 , F16K99/0007 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K2099/0069 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T29/49412 , Y10T137/87314
摘要: A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.
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公开(公告)号:US20050092658A1
公开(公告)日:2005-05-05
申请号:US10940143
申请日:2004-09-13
申请人: Sebastian Bohm , John Gilbert , Manish Deshpande
发明人: Sebastian Bohm , John Gilbert , Manish Deshpande
CPC分类号: B03B5/00 , B01L3/5027 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0028 , F16K99/0046 , F16K99/0048 , F16K99/0061 , F16K2099/0084 , G01N15/14 , G01N2015/149 , Y10S209/906 , Y10S209/932
摘要: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
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公开(公告)号:US20080086885A1
公开(公告)日:2008-04-17
申请号:US11973266
申请日:2007-10-05
申请人: John Gilbert , Bernard Bunner , Sebastian Bohm , Manish Deshpande
发明人: John Gilbert , Bernard Bunner , Sebastian Bohm , Manish Deshpande
IPC分类号: B21K1/20
CPC分类号: F16K99/0001 , F15C5/00 , F16K99/0005 , F16K99/0007 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K2099/0069 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T29/49412 , Y10T137/87314
摘要: A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.
摘要翻译: 用于调节微量级液体流动的闭锁微调节器包括具有入口端口和出口端口的基板,限定用于打开和关闭入口端口的阀室的阀元件以及用于致动阀元件的致动器组件。 阀室被构造成容纳一定体积的流体,并且入口端口和出口端口与阀室流体连通以提供通过该腔室的液体流动路径。 致动器组件包括用于在打开位置和关闭位置之间移动阀元件的悬臂梁,用于移动悬臂梁的致动器(例如压电元件)以及用于固定悬臂的闩锁(例如永磁体) 梁处于关闭位置。 流量调节系统包括多个不同流量的流体通道和多个用于选择性地阻塞或允许流过每个流体通道的闭锁微调节器。
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公开(公告)号:US20060266679A1
公开(公告)日:2006-11-30
申请号:US11499953
申请日:2006-08-07
申请人: Sebastian Bohm , John Gilbert , Manish Deshpande
发明人: Sebastian Bohm , John Gilbert , Manish Deshpande
IPC分类号: B07C5/38
CPC分类号: B03B5/00 , B01L3/5027 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0028 , F16K99/0046 , F16K99/0048 , F16K99/0061 , F16K2099/0084 , G01N15/14 , G01N2015/149 , Y10S209/906 , Y10S209/932
摘要: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
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公开(公告)号:US20050166975A1
公开(公告)日:2005-08-04
申请号:US11099014
申请日:2005-04-04
申请人: John Gilbert , Bernard Bunner , Sebastian Bohm , Manish Deshpande
发明人: John Gilbert , Bernard Bunner , Sebastian Bohm , Manish Deshpande
CPC分类号: F16K99/0001 , F15C5/00 , F16K99/0005 , F16K99/0007 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K2099/0069 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T29/49412 , Y10T137/87314
摘要: A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.
摘要翻译: 用于调节微量级液体流动的闭锁微调节器包括具有入口端口和出口端口的基板,限定用于打开和关闭入口端口的阀室的阀元件以及用于致动阀元件的致动器组件。 阀室被构造成容纳一定体积的流体,并且入口端口和出口端口与阀室流体连通以提供通过该腔室的液体流动路径。 致动器组件包括用于在打开位置和关闭位置之间移动阀元件的悬臂梁,用于移动悬臂梁的致动器(例如压电元件)以及用于固定悬臂的闩锁(例如永磁体) 梁处于关闭位置。 流量调节系统包括多个不同流量的流体通道和多个用于选择性地阻塞或允许流过每个流体通道的闭锁微调节器。
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公开(公告)号:US20100133151A1
公开(公告)日:2010-06-03
申请号:US12537802
申请日:2009-08-07
IPC分类号: B03B5/00
CPC分类号: B03B5/00 , B01L3/5027 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0028 , F16K99/0046 , F16K99/0048 , F16K99/0061 , F16K2099/0084 , G01N15/14 , G01N2015/149 , Y10S209/906 , Y10S209/932
摘要: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
摘要翻译: 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀,用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块,其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置,以便降低误差率。
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