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21 条记录 (耗时 0.039 秒)

    2,6-diaminopyridine derivatives
    1.
    发明授权
    2,6-diaminopyridine derivatives 失效
    2,6-二氨基吡啶衍生物

    公开(公告)号：US07423051B2

    公开(公告)日：2008-09-09

    申请号：US11165912

    申请日：2005-06-24

    申请人： David Joseph Bartkovitz ,  Xin-Jie Chu ,  Allen John Lovey ,  Peter Michael Wovkulich

    发明人： David Joseph Bartkovitz ,  Xin-Jie Chu ,  Allen John Lovey ,  Peter Michael Wovkulich

    IPC分类号： A61K31/4545 ,  C07D401/12

    CPC分类号： C07D213/73

    摘要： Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

    摘要翻译： 公开了下述新的2,6-二氨基吡啶衍生物，其中R 1和R 2定义如下。 这些化合物抑制细胞周期蛋白依赖性激酶。 这些化合物及其药学上可接受的盐和酯具有抗增殖活性，并且可用于治疗或控制癌症，特别是实体瘤。 本发明还涉及含有这些化合物的药物组合物以及治疗或控制癌症的方法，特别是乳腺癌，肺癌，结肠癌和前列腺肿瘤的治疗或控制。 还公开了可用于制备这些新型2,6-二氨基吡啶衍生物的中间体。

    4-Aminothiazole derivatives
    7.
    发明授权
    4-Aminothiazole derivatives 失效
    4-氨基噻唑衍生物

    公开(公告)号：US07423053B2

    公开(公告)日：2008-09-09

    申请号：US11170636

    申请日：2005-06-29

    申请人： Li Chen ,  Xin-Jie Chu ,  Allen John Lovey ,  Chunlin Zhao

    发明人： Li Chen ,  Xin-Jie Chu ,  Allen John Lovey ,  Chunlin Zhao

    IPC分类号： A61K31/4523 ,  C07D417/02

    CPC分类号： C07D277/20 ,  C07D277/42 ,  C07D417/12

    摘要： Novel 4-aminothiazole derivatives are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminothiazole derivatives.

    摘要翻译： 公开了新的4-氨基噻唑衍生物。 这些化合物抑制细胞周期蛋白依赖性激酶。 这些化合物及其药学上可接受的盐和酯具有抗增殖活性，并且可用于治疗或控制癌症，特别是实体瘤。 本发明还涉及含有这些化合物的药物组合物以及治疗或控制癌症的方法，特别是乳腺癌，肺癌，结肠癌和前列腺肿瘤的治疗或控制。 还公开了可用于制备这些新型4-氨基噻唑衍生物的中间体。