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公开(公告)号:US20070148655A1
公开(公告)日:2007-06-28
申请号:US10589305
申请日:2005-02-14
CPC分类号: C07K14/705
摘要: This invention relates to the novel protein, termed INSP (179), herein identified as a secreted protein, in particular as a member of the leucine rich repeat containing protein family and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP(179)的新型蛋白质,其在本文中被鉴定为分泌蛋白质,特别是作为含有富含亮氨酸重复序列的蛋白质家族的成员,以及来自编码基因的该蛋白质和核酸序列的用途 诊断,预防和治疗疾病。
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公开(公告)号:US08222371B2
公开(公告)日:2012-07-17
申请号:US11718183
申请日:2005-10-28
CPC分类号: C07K14/70503 , A61K38/00 , Y02A50/469
摘要: Proteins (INSP141, INSP142, INSP143, and INSP144) identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease are described.
摘要翻译: 鉴定为蛋白质(INSP141,INSP142,INSP143和INSP144),其被鉴定为含有血管性血友病因子A(vWFA)和炭疽芽孢杆菌受体胞外(ANT_IG)结构域的炭疽受体样蛋白,并且使用来自编码基因的这些蛋白质和核酸序列 描述了疾病的诊断,预防和治疗。
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公开(公告)号:US20090214548A1
公开(公告)日:2009-08-27
申请号:US11721291
申请日:2005-12-08
IPC分类号: A61K39/395 , A61K39/00 , A61K35/00 , A61K38/43 , C12Q1/68 , G01N33/53 , C40B40/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K31/7088 , C07K14/435 , A01K67/00
CPC分类号: C07K14/71 , A61K38/00 , G01N33/74 , G01N2333/71
摘要: There are provided proteins containing a domain corresponding to the C-terminal half of a ZP domain similar to that identified in TGF-beta Receptor III and the use of the proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of diseases. In particular, the present invention relates to the use of the disclosed proteins for modulating the activity of proteins belonging to the TGF-beta superfamily.
摘要翻译: 提供的蛋白质含有对应于与TGF-β受体III中鉴定的ZP结构域的C末端半部分相关的结构域,以及来自编码基因的蛋白质和核酸序列在诊断,预防和治疗中的用途 疾病 特别地,本发明涉及所公开的蛋白质用于调节属于TGF-β超家族的蛋白质的活性的用途。
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公开(公告)号:US20090104197A1
公开(公告)日:2009-04-23
申请号:US11718183
申请日:2005-10-28
IPC分类号: A61K39/395 , C12Q1/68 , A61K39/02 , C40B40/08 , G01N33/53 , C07K14/00 , A61K35/00 , A61K31/7088 , A61K38/16
CPC分类号: C07K14/70503 , A61K38/00 , Y02A50/469
摘要: This invention relates to novel proteins (herein termed INSP141, INSP142, INSP143, and INSP144), herein identified as anthrax receptor-like proteins containing von Willebrand factor A (vWFA) and Anthrax receptor extracellular (ANT_IG) domains and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及新型蛋白质(本文称为INSP141,INSP142,INSP143和INSP144),其被鉴定为含有血管性血友病因子A(vWFA)和炭疽芽孢杆菌受体胞外(ANT_IG)结构域的炭疽受体样蛋白质,以及这些蛋白质的使用 和来自编码基因的核酸序列在疾病的诊断,预防和治疗中。
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公开(公告)号:US20090042775A1
公开(公告)日:2009-02-12
申请号:US10539656
申请日:2004-01-13
CPC分类号: C07K14/4723
摘要: This invention relates to novel proteins, termed INSP 108 and INSP 109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP 108和INSP 109的新型蛋白质,其在本文中被鉴定为蛋白质防卫素家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20070274992A1
公开(公告)日:2007-11-29
申请号:US10554816
申请日:2004-04-30
CPC分类号: C07K14/47 , A61K38/00 , Y02A90/26 , Y10T436/143333
摘要: This invention relates to a new family of secreted proteins, termed the SECFAM3 family, its family members including the novel human proteins INSP123, INSP124, and INSP125, herein identified as secreted proteins containing a von Willebrand Factor type C (vWFC) domain, and to the use to these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及称为SECFAM3家族的新型分泌蛋白家族,其家族成员包括新型人蛋白质INSP123,INSP124和INSP125,其鉴定为含有von Willebrand因子C型(vWFC)结构域的分泌蛋白质,以及 用于这些蛋白质和核酸序列的编码基因的诊断,预防和治疗疾病。
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公开(公告)号:US20090324562A1
公开(公告)日:2009-12-31
申请号:US12494875
申请日:2009-06-30
CPC分类号: C07K14/4723
摘要: This invention relates to the novel proteins, termed INSP108 and INSP109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP108和INSP109的新型蛋白质,其在本文中被鉴定为蛋白防御素家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20090215672A1
公开(公告)日:2009-08-27
申请号:US12096135
申请日:2006-12-07
IPC分类号: A61K38/17 , C07K14/47 , C12N15/12 , C12N15/85 , C12N5/10 , C07K16/18 , C12Q1/68 , A61K31/711 , A01K67/027 , A61B10/00 , G01N33/566 , A61P35/00 , A61P35/02 , A61P15/08 , A61P11/00 , A61P19/02 , A61P19/10 , A61P37/00 , A61P17/06 , A61P11/06 , A61P9/10 , A61P9/12 , A61P25/28 , A61P29/00 , A61P3/04 , A61P25/00 , A61P31/04 , A61P31/18 , A61P31/10 , A61P33/00
CPC分类号: C07K14/705
摘要: This invention relates to novel proteins, termed INSP206 and INSP208 herein identified as Cys-rich, cell surface glycoproteins, and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP206和INSP208的新型蛋白质,其被鉴定为富含Cys的细胞表面糖蛋白,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US07563767B2
公开(公告)日:2009-07-21
申请号:US10539656
申请日:2004-01-13
IPC分类号: A61K38/17 , C07K14/435 , C12P21/02
CPC分类号: C07K14/4723
摘要: This invention relates to novel proteins, termed INSP 108 and INSP 109, herein identified as members of the defensin family of proteins and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为INSP 108和INSP 109的新型蛋白质,其在本文中被鉴定为蛋白质防卫素家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20060263776A1
公开(公告)日:2006-11-23
申请号:US10538197
申请日:2003-12-11
CPC分类号: C12N9/6424
摘要: This invention relates to a novel protein, termed INTP039, herein identified as a serine protease, in particular, as a member of the trypsin family of proteins and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及一种称为INTP039的新型蛋白质,本文鉴定为丝氨酸蛋白酶,特别是作为蛋白质胰蛋白酶家族的成员,以及来自编码基因的该蛋白质和核酸序列在诊断,预防中的用途 ,治疗疾病。
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