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    Method for diagnosis and therapy of Hodgkin's lymphomas
    6.
    发明授权
    Method for diagnosis and therapy of Hodgkin's lymphomas 失效
    霍奇金淋巴瘤的诊断和治疗方法

    公开(公告)号：US06372441B1

    公开(公告)日：2002-04-16

    申请号：US09331254

    申请日：1999-12-21

    申请人： Karl-Heinz Heider ,  Kurt Zatloukal ,  Christine Beham-Schmid

    发明人： Karl-Heinz Heider ,  Kurt Zatloukal ,  Christine Beham-Schmid

    IPC分类号： G01N3353

    CPC分类号： C07K16/2884 ,  G01N33/57492 ,  G01N33/6878

    摘要： The invention relates to a method for diagnosing and treating Hodgkin's lymphomas (lymphogranulomatosis) which is based on the expression of the variant exon v10 of the CD44 gene as a molecular marker or target. There is a significant correlation between v10 expression and the stage and prognosis of the disease. In a preferred embodiment, v10-specific antibody molecules are used to measure the expression of the exon in samples. In another preferred embodiment, radiolabelled v10-specific antibodies are used to treat Hodgkin's lymphomas.

    摘要翻译： 本发明涉及一种用于诊断和治疗霍奇金淋巴瘤（淋巴肉芽肿病）的方法，其基于CD44基因的变体外显子v10作为分子标记或靶标的表达。 v10表达与疾病的阶段和预后有显着的相关性。 在优选的实施方案中，使用v10特异性抗体分子来测量样品中外显子的表达。 在另一个优选的实施方案中，放射性标记的v10特异性抗体用于治疗霍奇金淋巴瘤。

    Biopsy device
    8.
    发明授权
    Biopsy device 失效
    活检装置

    公开(公告)号：US4850373A

    公开(公告)日：1989-07-25

    申请号：US173632

    申请日：1988-03-25

    申请人： Kurt Zatloukal ,  Hans P. Dinges

    发明人： Kurt Zatloukal ,  Hans P. Dinges

    IPC分类号： A61B10/02 ,  A61B10/00 ,  A61M5/00 ,  A61M5/158 ,  A61M25/00

    CPC分类号： A61B10/0283 ,  A61M25/0032 ,  A61M5/1582

    摘要： A biopsy device including a two- or multi-lumen biopsy cannula has a biopsy channel of constant cross section over its entire length and at least one application channel. On its proximal end, it is provided with connection facilities for an aspiration device and at least one application device. In order to enable the collection of tissue specimens of an unchanged structure with the most careful handling possible of the tissue and the application of auxiliary substances into the puncture channel without tissue specimens getting into the application cannula and obstructing the same, the cutting edge is formed by an acute-angularly designed end of the biopsy channel wall alone. At least one application channel is formed by a tube eccentrically slipped over the biopsy channel wall. The biopsy channel wall projects out of the tube with its cutting edge and the tube end encloses an obtuse angle with the biopsy channel.

    摘要翻译： 包括二腔或多腔活检插管的活检装置具有在其整个长度上恒定横截面的活检通道和至少一个施加通道。 在其近端设置有用于抽吸装置和至少一个施用装置的连接装置。 为了能够收集不变结构的组织标本，尽可能仔细地处理组织和将辅助物质施用到穿刺通道中，而组织样本不会进入施加套管并阻塞，从而形成切割边缘 通过活检通道壁单独的锐角设计的端部。 至少一个应用通道由偏心地滑过活检通道壁的管形成。 活检通道壁从切割边缘突出出管，管端与活检通道封闭钝角。

    METHOD AND DEVICE FOR AUTOMATICALLY ANALYZING BIOLOGICAL SAMPLES
    9.
    发明申请
    METHOD AND DEVICE FOR AUTOMATICALLY ANALYZING BIOLOGICAL SAMPLES 审中-公开
    用于自动分析生物样品的方法和装置

    公开(公告)号：US20100208955A1

    公开(公告)日：2010-08-19

    申请号：US12095596

    申请日：2006-11-29

    申请人： Gabor Méhes ,  Wolfgang Schmidt ,  Christopher Wrighton ,  Kurt Zatloukal ,  Harald Zobl ,  Peter Hecht

    发明人： Gabor Méhes ,  Wolfgang Schmidt ,  Christopher Wrighton ,  Kurt Zatloukal ,  Harald Zobl ,  Peter Hecht

    IPC分类号： G06K9/00

    CPC分类号： G01N21/6452 ,  G01N21/6458 ,  G01N21/6486 ,  G06K9/00134 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024 ,  G06T2207/30072

    摘要： The invention relates to a method for automatic analysis of biological samples, in particular tissue samples, comprising a device (11) for scanning the samples (1) for forming data sets (4) of the samples (1). To produce a method or a device (10) by which the regions of interest (ROI) of the sample (1) can be determined as quickly as possible and as much as possible without destroying the samples (1), at least one parameter (P) is selected without destroying the sample (1) from a data set (4) of the sample (1) that is formed by using autofluorescence, and this parameter or a value derived therefrom or a combination of parameters (P) or values derived therefrom is compared to at least one threshold value (S), and the comparison value is used as a criterion for determining regions of interest (ROI) of the sample (1) and stored together with a unique identification (ID) of the sample (1).

    摘要翻译： 本发明涉及用于自动分析生物样品，特别是组织样品的方法，其包括用于扫描样品（1）以形成样品（1）的数据集（4）的装置（11）。 为了产生方法或装置（10），通过该方法或装置（10）可以尽可能快地尽可能快地确定样本（1）的感兴趣区域（ROI）而不破坏样本（1），至少一个参数（ P）被选择，而不会从通过使用自发荧光形成的样品（1）的数据集（4）中破坏样品（1），并且该参数或其衍生的值或参数（P）或值的组合 将其与至少一个阈值（S）进行比较，并将比较值用作用于确定样本（1）的感兴趣区域（ROI）的标准并与样本的唯一标识（ID）一起存储 1）。