公开(公告)号：US20090145576A1

公开(公告)日：2009-06-11

申请号：US11719520

申请日：2006-08-10

申请人： David W. Wyrick ,  Daniel M. Hartmann ,  Joshua T. Nevill ,  Mehul Patell ,  Michael G. Pollack ,  Gregory A. Votaw ,  Hugh C. Crenshaw

发明人： David W. Wyrick ,  Daniel M. Hartmann ,  Joshua T. Nevill ,  Mehul Patell ,  Michael G. Pollack ,  Gregory A. Votaw ,  Hugh C. Crenshaw

IPC分类号： F28F27/00 ,  B01J19/00

CPC分类号： B01L3/502715 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01J2219/00961 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/565 ,  B01L7/00 ,  B01L9/527 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0487 ,  F28F3/02

摘要： An actively temperature regulated microfluidic chip assembly includes a first thermally conductive body, a second thermally conductive body attached to the first thermally conductive body, a microfluidic chip encapsulated between the first and second thermally conductive bodies, and a temperature regulating element mounted to the first thermally conductive body for adding heat to or alternately removing heat from the chip. The temperature of the chip and thus the liquid contained and/or flowing therein can be regulated by measuring the temperature of the liquid and operating the temperature regulating element to establish a thermal gradient toward or alternately away from the liquid based on the measured temperature and in comparison with a desired set point temperature.

摘要翻译： 主动温度调节的微流体芯片组件包括第一导热体，连接到第一导热体的第二导热体，封装在第一和第二导热体之间的微流体芯片，以及安装在第一导热体上的温度调节元件 导电体，用于向芯片加热或交替地从芯片中去除热量。 可以通过测量液体的温度和操作温度调节元件来调节芯片的温度，从而使其中含有和/或流过的液体的温度基于测量的温度和/或在 与所需设定点温度进行比较。

公开(公告)号：US20090142198A1

公开(公告)日：2009-06-04

申请号：US11719518

申请日：2006-08-10

申请人： Gregory A. Votaw ,  Charles A. Buckner ,  Daniel M. Hartmann ,  William Karsh ,  Frank Anthony Montefusco ,  Joshua T. Nevill ,  Mehul Patel ,  David W. Wyrick ,  Hugh C. Crenshaw

发明人： Gregory A. Votaw ,  Charles A. Buckner ,  Daniel M. Hartmann ,  William Karsh ,  Frank Anthony Montefusco ,  Joshua T. Nevill ,  Mehul Patel ,  David W. Wyrick ,  Hugh C. Crenshaw

IPC分类号： F04B49/06 ,  F04B35/04 ,  A61M1/00

CPC分类号： F04B19/006 ,  B01J2219/0081 ,  B01J2219/00891 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/565 ,  B01L7/52 ,  B01L2300/0896 ,  B01L2400/0478 ,  B82Y30/00 ,  F04B9/02 ,  F04B23/06 ,  G01N2035/00158

摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.

摘要翻译： 以纳米级速率处理流体的装置和方法。 线性位移泵产生低至nl / mm范围的非脉动液体流速。 泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。 微流体互连装置可以联接到枪管。 这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置 在与泵的桶或桶相对的一侧与导热体接触。

公开(公告)号：US08021130B2

公开(公告)日：2011-09-20

申请号：US11719518

申请日：2006-08-10

申请人： Gregory A. Votaw ,  Charles A. Buckner ,  Daniel M. Hartmann ,  William Karsh ,  Frank Anthony Montefusco ,  Joshua T. Nevill ,  Mehul Patel ,  David W. Wyrick ,  Hugh C. Crenshaw

发明人： Gregory A. Votaw ,  Charles A. Buckner ,  Daniel M. Hartmann ,  William Karsh ,  Frank Anthony Montefusco ,  Joshua T. Nevill ,  Mehul Patel ,  David W. Wyrick ,  Hugh C. Crenshaw

IPC分类号： F04B17/00

CPC分类号： F04B19/006 ,  B01J2219/0081 ,  B01J2219/00891 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/565 ,  B01L7/52 ,  B01L2300/0896 ,  B01L2400/0478 ,  B82Y30/00 ,  F04B9/02 ,  F04B23/06 ,  G01N2035/00158

摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.

摘要翻译： 以纳米级速率处理流体的装置和方法。 线性位移泵产生低至nl / mm范围的非脉动液体流速。 泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。 微流体互连装置可以联接到枪管。 这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置 在与泵的桶或桶相对的一侧与导热体接触。

公开(公告)号：US20090139576A1

公开(公告)日：2009-06-04

申请号：US11719524

申请日：2006-08-10

申请人： Hugh C. Crenshaw ,  Jennifer Colonell ,  Daniel M. Hartmann ,  Joshua T. Nevill ,  David W. Wyrick

发明人： Hugh C. Crenshaw ,  Jennifer Colonell ,  Daniel M. Hartmann ,  Joshua T. Nevill ,  David W. Wyrick

IPC分类号： G05D11/03 ,  B81B7/04

CPC分类号： B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/5027 ,  Y10T137/0329 ,  Y10T137/86131 ,  Y10T137/87249

摘要： Microfluidic Systems, Devices and Methods for Reducing Noise Generated by Mechanical Instabilities. According to one embodiment, a microfluidic device is provided for reducing noise in a fluid mix. The microfluidic device can include microscale channels for passage of fluids to a mixing junction. The mixing channel can be adapted to combine the fluids into a common fluid flow. The microfluidic device can also include a connector channel including first and second ends. The first end of the connector channel can be connected to the mixing junction. The microfluidic device can also include an expansion channel having connection to the second end of the connector channel. The expansion channel can be adapted for passage of the fluid mix through the expansion channel to reduce concentration gradient noise of the fluid mix by dispersion of the fluid mix as the fluid mix passes through the expansion channel.

摘要翻译： 微流控系统，降低机械不稳定噪声的设备和方法。 根据一个实施例，提供了用于减少流体混合物中的噪声的微流体装置。 微流体装置可以包括用于将流体通过混合结的微量通道。 混合通道可适于将流体组合成公共的流体流。 微流体装置还可以包括包括第一端和第二端的连接器通道。 连接器通道的第一端可以连接到混合连接点。 微流体装置还可以包括具有连接到连接器通道的第二端的扩张通道。 膨胀通道可适于使流体混合物通过膨胀通道，以在流体混合物通过膨胀通道时通过流体混合物的分散来减小流体混合物的浓度梯度噪声。

公开(公告)号：US20100199750A1

公开(公告)日：2010-08-12

申请号：US12367407

申请日：2009-02-06

申请人： Don W. Arnold ,  Nicole E. Hebert ,  Patrick Leung ,  David W. Wyrick ,  Phillip H. Paul

发明人： Don W. Arnold ,  Nicole E. Hebert ,  Patrick Leung ,  David W. Wyrick ,  Phillip H. Paul

IPC分类号： G01N30/02 ,  G01N27/26

CPC分类号： B01L3/502715 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2300/021 ,  B01L2300/18

摘要： A microfluidic processing system having a manifold with at least one inlet; at least one outlet; and a plurality of microfluidic chip holders. A fluidic jumper is coupled to one of the chip holders and at least two fluidic elements are coupled to at least one of the chip holders. The fluidic jumper controls the fluidic path through the system.

摘要翻译： 一种具有至少一个入口的歧管的微流体处理系统; 至少一个出口; 和多个微流体芯片保持器。 流体跳线耦合到芯片保持器中的一个，并且至少两个流体元件耦合到至少一个芯片保持器。 流体跳线控制通过系统的流体路径。