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1.发明授权公开(公告)号：US10537661B2
公开(公告)日：2020-01-21
申请号：US15472189
申请日：2017-03-28
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
IPC分类号： A61L27/32 , A61L27/06 , A61L27/56 , A61L27/58 , A61L27/54 , B05D1/18 , B05D3/00 , C23C16/40 , C23C16/455 , C25D9/04
摘要： An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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公开(公告)号：US10537658B2
公开(公告)日：2020-01-21
申请号：US15472186
申请日：2017-03-28
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
IPC分类号： A61L27/04 , A61L27/12 , A61L27/06 , A61L27/32 , A61L31/08 , A61L27/56 , A61L27/50 , A61L27/58 , A61L27/02
摘要： An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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3.发明授权公开(公告)号：US11793910B2
公开(公告)日：2023-10-24
申请号：US17344325
申请日：2021-06-10
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
IPC分类号： A61L27/32 , A61L27/06 , A61L27/56 , A61L27/58 , A61L27/04 , A61L27/50 , A61L27/54 , B05D1/18 , B05D3/00 , C23C16/40 , C23C16/455 , C25D9/04
CPC分类号： A61L27/32 , A61L27/045 , A61L27/06 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2300/412 , A61L2300/606 , A61L2400/12 , A61L2420/02 , A61L2430/02 , B05D1/18 , B05D3/002 , C23C16/405 , C23C16/45525 , C25D9/04
摘要： An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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公开(公告)号：US20210402055A1
公开(公告)日：2021-12-30
申请号：US17474610
申请日：2021-09-14
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
IPC分类号： A61L27/12 , A61L27/06 , A61L27/56 , A61L27/50 , A61L27/04 , A61L27/58 , A61L27/32 , A61L27/02
摘要： An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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5.发明公开公开(公告)号：US20240009347A1
公开(公告)日：2024-01-11
申请号：US18372860
申请日：2023-09-26
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
IPC分类号： A61L27/12 , A61L27/06 , A61L27/56 , A61L27/50 , A61L27/04 , A61L27/58 , A61L27/32 , A61L27/02
CPC分类号： A61L27/12 , A61L27/06 , A61L27/56 , A61L27/50 , A61L27/045 , A61L27/58 , A61L27/32 , A61L27/025 , A61L27/047
摘要： An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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公开(公告)号：US11141505B2
公开(公告)日：2021-10-12
申请号：US16725444
申请日：2019-12-23
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
IPC分类号： A61L27/12 , A61L27/06 , A61L27/56 , A61L27/50 , A61L27/58 , A61L27/32 , A61L27/04 , A61L27/02
摘要： An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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7.发明公开公开(公告)号：US20240024535A1
公开(公告)日：2024-01-25
申请号：US18372863
申请日：2023-09-26
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
CPC分类号： A61L27/32 , A61L27/06 , A61L27/56 , A61L27/58 , A61L27/045 , A61L27/50 , A61L27/54 , A61L2400/12 , A61L2430/02 , A61L2300/112 , A61L2300/412 , A61L2300/606 , A61L2420/02 , B05D1/18
摘要： An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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8.发明申请公开(公告)号：US20210299328A1
公开(公告)日：2021-09-30
申请号：US17344325
申请日：2021-06-10
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
摘要： An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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公开(公告)号：US11793907B2
公开(公告)日：2023-10-24
申请号：US17474610
申请日：2021-09-14
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
IPC分类号： A61L27/12 , A61L27/04 , A61L27/02 , A61L27/06 , A61L27/32 , A61L27/50 , A61L27/56 , A61L27/58
CPC分类号： A61L27/12 , A61L27/025 , A61L27/045 , A61L27/047 , A61L27/06 , A61L27/32 , A61L27/50 , A61L27/56 , A61L27/58
摘要： An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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10.发明授权公开(公告)号：US11058799B2
公开(公告)日：2021-07-13
申请号：US16725466
申请日：2019-12-23
发明人： Rajendra Kasinath , Craig Ernsberger , Stephanie Vass , Steven N. Ginn , Haibo Qu , Weidong Tong
IPC分类号： A61L27/32 , A61L27/06 , A61L27/56 , A61L27/58 , A61L27/04 , A61L27/50 , A61L27/54 , B05D1/18 , B05D3/00 , C23C16/40 , C23C16/455 , C25D9/04
摘要： An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.
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