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    Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
    1.
    发明授权
    Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase 失效
    杂芳基杂烷基胺衍生物及其作为一氧化氮合酶抑制剂的用途

    公开(公告)号：US07119109B2

    公开(公告)日：2006-10-10

    申请号：US10484960

    申请日：2002-07-26

    申请人： Deborah Chen ,  David Cheshire ,  Stephen Connolly ,  Antonio Mete

    发明人： Deborah Chen ,  David Cheshire ,  Stephen Connolly ,  Antonio Mete

    IPC分类号： A61K31/44 ,  C07D211/78

    CPC分类号： A61K31/44 ,  C07D213/85

    摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease, CNS disorders and pain.

    摘要翻译： 提供了新的式（I）化合物，其中R 1，R 2，R 3，T，U，X，Y，V 和W如说明书中所定义，及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎症性疾病，中枢神经系统疾病和疼痛。

    Novel 6-substituted 2-aminopyridine derivatives
    6.
    发明申请
    Novel 6-substituted 2-aminopyridine derivatives 审中-公开
    新的6-取代的2-氨基吡啶衍生物

    公开(公告)号：US20060194847A1

    公开(公告)日：2006-08-31

    申请号：US10551494

    申请日：2004-03-30

    申请人： David Cheshire ,  Stephen Connolly ,  Timothy Luker

    发明人： David Cheshire ,  Stephen Connolly ,  Timothy Luker

    IPC分类号： C07D213/75 ,  A61K31/44

    CPC分类号： C07D213/73

    摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, L1, L2, L3 and Q are are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

    摘要翻译： 提供了新的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9， ，L 1，L 2，L 3和Q如说明书中所定义，及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病和疼痛。

    Novel n-substituted 2-aminopyridine derivatives
    8.
    发明申请
    Novel n-substituted 2-aminopyridine derivatives 审中-公开
    新的n-取代的2-氨基吡啶衍生物

    公开(公告)号：US20060270714A1

    公开(公告)日：2006-11-30

    申请号：US10551495

    申请日：2004-03-30

    申请人： David Cheshire ,  Stephen Connolly ,  Timothy Luker ,  Jeffrey Stonehouse

    发明人： David Cheshire ,  Stephen Connolly ,  Timothy Luker ,  Jeffrey Stonehouse

    IPC分类号： C07D213/78 ,  A61K31/44

    CPC分类号： C07D213/74

    摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R17, L1, L2, L3 and Q are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

    摘要翻译： 提供了新的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9， R 17，L 1，L 2，L 3和Q如说明书中所定义，和 其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病和疼痛。