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    Diagnostic method for stroke
    6.
    发明申请
    Diagnostic method for stroke 审中-公开
    中风诊断方法

    公开(公告)号：US20050153360A1

    公开(公告)日：2005-07-14

    申请号：US10909761

    申请日：2004-08-02

    申请人： Denis Hochstrasser ,  Jean-Charles Sanchez ,  Elisabeth Guillaume ,  Laure Allard

    发明人： Denis Hochstrasser ,  Jean-Charles Sanchez ,  Elisabeth Guillaume ,  Laure Allard

    IPC分类号： G01N33/00 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  G01N33/6848 ,  G01N2800/2871

    摘要： The present invention provides a method of diagnosis of stroke or the possibility thereof in a subject suspected of suffering from stroke, comprising subjecting a sample of body fluid taken from the subject to mass spectrometry to determine a test amount of a polypeptide in the sample, wherein the polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000 Da; and determining whether the test amount is consistent with a diagnosis of stroke. The test amount can also be used to determine the type of stroke that is diagnosed, in particular whether it is of the ischemic or hemorrhagic type. The invention also provides use of the polypeptides for diagnostic, prognostic and therapeutic applications. The invention further provides a kit for use in diagnosis of stroke, comprising a probe for receiving a sample of body fluid, and for placement in a mass spectrometer, thereby to determine a test amount of a polypeptide in the sample, wherein the polypeptide is differentially contained in the body fluid of stroke-affected subjects and non-stroke-affected subjects, and has a molecular weight in the range of from 3000 to 30000 Da.

    摘要翻译： 本发明提供了一种诊断中风的方法或其在怀疑患有中风的受试者中的可能性，包括使得自受试者取得的体液样品进行质谱以确定样品中多肽的检测量，其中 该多肽差异包含在中风受影响的受试者和非中风受试者的体液中，分子量在3000至30000Da的范围内; 并确定测试量是否与中风的诊断一致。 测试量也可用于确定被诊断的中风的类型，特别是是否是缺血性或出血型。 本发明还提供了多肽用于诊断，预后和治疗应用的用途。 本发明还提供了一种用于卒中诊断的试剂盒，其包括用于接收体液样品的探针，并用于放置在质谱仪中，由此确定样品中多肽的检测量，其中多肽是差异的 包含在中风影响的受试者和非中风受试者的体液中，分子量在3000至30000Da的范围内。

    Diagnostic Methods
    9.
    发明申请
    Diagnostic Methods 审中-公开
    诊断方法

    公开(公告)号：US20130252834A1

    公开(公告)日：2013-09-26

    申请号：US13699444

    申请日：2011-05-23

    申请人： Loic Gerard Dayon ,  Jean-Charles Sanchez ,  Joan Montaner Villalonga

    发明人： Loic Gerard Dayon ,  Jean-Charles Sanchez ,  Joan Montaner Villalonga

    IPC分类号： G01N33/68 ,  C12N9/00 ,  C12N9/10 ,  C12Q1/26 ,  C12Q1/48

    CPC分类号： G01N33/6896 ,  C12N9/0065 ,  C12N9/1088 ,  C12Q1/26 ,  C12Q1/48 ,  G01N2800/2871 ,  G01N2800/50

    摘要： The invention relates to a method of aiding the diagnosis of acute brain damage in a subject, said method comprising (i) assaying the concentration of at least one oxidative stress polypeptide selected from the group consisting of: PRDX1, PRDX6 and GSTP1 in a sample from said subject; and (ii) assaying the concentration of at least one further polypeptide selected from Panel A; (Hi) comparing the concentrations of (i) and (ii) to the concentrations of the polypeptides in a reference standard and determining quantitative ratios for said polypeptides; (iv) wherein a finding of a quantitative ratio of each of the assayed polypeptides in the sample to the polypeptides in the reference standard of greater than 1.3 indicates an increased likelihood of acute brain damage having occurred in said subject.

    摘要翻译： 本发明涉及一种帮助受试者急性脑损伤诊断的方法，所述方法包括（i）测定至少一种选自以下的氧化应激多肽的浓度：PRDX1，PRDX6和GSTP1 主题; 和（ii）测定选自A组的至少一种其他多肽的浓度; （Hi）将参考标准中的（i）和（ii）的浓度与多肽的浓度进行比较并确定所述多肽的定量比例; （iv）其中样品中每个测定的多肽与参考标准中的多肽的定量比例大于1.3的发现表明在所述受试者中发生急性脑损伤的可能性增加。