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    Compounds which have activity at M1 receptor and their uses in medicine
    4.
    发明授权
    Compounds which have activity at M1 receptor and their uses in medicine 失效
    具有M1受体活性的化合物及其在药物中的用途

    公开(公告)号：US08288412B2

    公开(公告)日：2012-10-16

    申请号：US12088451

    申请日：2006-09-27

    申请人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    发明人： Brian Budzik ,  David Gwyn Cooper ,  Ian Thomson Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Paul William Smith ,  Graham Walker

    IPC分类号： A61K31/454 ,  C07D405/04

    CPC分类号： C07D401/14

    摘要： Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）和盐的化合物：其中R 5选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基，被一个或多个氟原子取代的C 1-6烷氧基， 和氰基; R 6选自卤素，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基，被一个或多个 氟原子和氰基; Q是氢或C 1-6烷基。 化合物是M1激动剂，可用于治疗，例如治疗精神病和认知障碍。

    Compounds which have activity at M1 receptor and their uses in medicine.
    6.
    发明申请
    Compounds which have activity at M1 receptor and their uses in medicine. 失效
    具有M1受体活性的化合物及其在药物中的用途。

    公开(公告)号：US20080058378A1

    公开(公告)日：2008-03-06

    申请号：US11852455

    申请日：2007-09-10

    申请人： Brian Budzik ,  David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

    发明人： Brian Budzik ,  David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Jian Jin ,  Dongchuan Shi ,  Graham Walker

    IPC分类号： A61K31/445 ,  A61P43/00

    CPC分类号： C07D405/12 ,  C07D235/26

    摘要： Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

    摘要翻译： 提供式（I）化合物和盐和溶剂化物：其中R 4是氟，R 5选自氢，卤素，氰基，C 1〜 C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基和C 1-6 - 被一个或多个氟原子取代的烷氧基; 和R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基， C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和C 1-6烷基， 1-6个被一个或多个氟原子取代的烷氧基，Q是氢或C 1-6烷基。 预期化合物可用于治疗，例如治疗精神病和认知障碍。