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公开(公告)号：US4388271A
公开(公告)日：1983-06-14
申请号：US300899
申请日：1981-09-10
申请人： Dieter Kraemer , Klaus Lehmann , Roland Hartl
发明人： Dieter Kraemer , Klaus Lehmann , Roland Hartl
CPC分类号： G01N33/725 , C12Q1/28 , Y10S436/904
摘要： The invention relates to diagnostic agents for the rapid diagnostic detection of blood in excretions and body fluids, consisting essentially of a solid support which is charged with a chromogenic substance as indicator and impregnated with an acrylic and/or methacrylic resin.
摘要翻译： 本发明涉及用于快速诊断检测排泄物和体液中的血液的诊断剂，其基本上由固体支持物组成，所述固体支持物装载有显色物质作为指示剂并用丙烯酸和/或甲基丙烯酸树脂浸渍。
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2.发明授权Method of bonding a polypeptide to a macromolecular polymeric carrier by irradiation with light 失效通过光照射将多肽与大分子聚合物载体结合的方法
公开(公告)号：US4039413A
公开(公告)日：1977-08-02
申请号：US426317
申请日：1973-12-19
申请人： Dieter Kraemer , Klaus Lehmann , Hermann Plainer
发明人： Dieter Kraemer , Klaus Lehmann , Hermann Plainer
IPC分类号： A61K39/44 , A61K41/00 , C07C67/00 , C07C231/00 , C07C231/12 , C07K17/08 , C12N11/08 , C12N11/12 , C12P21/04 , C08L1/00 , C08L3/00
CPC分类号： C12N11/08 , A61K39/44 , A61K41/0023
摘要： Methods for bonding a polypeptide to a macro-molecular carrier compound by irradiating an aqueous solution of the polypeptide, in the absence of oxygen and in the presence of said carrier compound, with ultraviolet light in the optional presence of a photosensitizer or with visible light in the presence of a photosensitizer and an organic peroxide.
摘要翻译： 将多肽与大分子载体化合物结合的方法，其中在无氧的情况下，在所述载体化合物的存在下，在任选的光敏剂存在下，或在可见光下，用紫外光照射多肽的水溶液 光敏剂和有机过氧化物的存在。
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公开(公告)号：US4070348A
公开(公告)日：1978-01-24
申请号：US544830
申请日：1975-01-28
CPC分类号： C08F2/14 , C12N11/08 , Y10S435/897 , Y10S526/909 , Y10S526/91
摘要： Water-swellable, cross-linked, bead copolymers of (A) an ethylenically unsaturated monomer having a carboxylic acid anhydride, glycidyl or succinimide group, (B) a comonomer having at least two radical-polymerizable carbon double bonds, and (C) a radical-polymerizable water-soluble comonomer are disclosed to be excellent carriers capable of bonding with biologically active substances such as enzymes, enzyme substrates, inhibitors, hormones, antibiotics, antigens, and peptides.
摘要翻译： （A）具有羧酸酐的烯键式不饱和单体，缩水甘油基或琥珀酰亚胺基，（B）具有至少两个可自由基聚合的碳双键的共聚单体的水溶胀性，交联的珠粒共聚物，（C） 可自由基聚合的水溶性共聚单体被公开为能够与酶，酶底物，抑制剂，激素，抗生素，抗原和肽等生物活性物质结合的优异载体。
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公开(公告)号：US5342646A
公开(公告)日：1994-08-30
申请号：US979425
申请日：1992-11-19
CPC分类号： G01N33/545 , C07K17/08 , C12N11/08
摘要： What is disclosed is a method for preparing carrier systems, adaptable to the covalent bonding thereto of biologically active materials, consisting of a known solid support material having a surface coated with a polymer containing functional groups suitable for covalent bonding, by coating the support material with a film-forming polymer dispersion and a non-film-forming polymer dispersion, suitably in admixture, at least one of the two polymer dispersions containing a polymer having functional groups suitable for covalent bonding with a biologically active material.
摘要翻译： 公开的是一种制备载体系统的方法，其适用于生物活性材料的共价键合，其由已知的固体支持材料组成，所述固体支持材料具有涂覆有包含适于共价键合的官能团的聚合物的表面，通过用 一种成膜聚合物分散体和一种非成膜聚合物分散体，适当地混合两种聚合物分散体中的至少一种，其含有具有适于与生物活性材料共价键合的官能团的聚合物。
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公开(公告)号：US06306428B1
公开(公告)日：2001-10-23
申请号：US09058951
申请日：1998-04-13
IPC分类号： A61K900
CPC分类号： A61K9/2095 , A61K9/2072 , A61K9/2086 , A61K9/7007
摘要： A time-release laminar pharmaceutical composition, comprised of rolled or folded layers of a polymer film, that contain a pharmaceutically active substance, in which the outer surface area of the polymer film which contains the active substance, and which is accessible to the digestive juices, amounts to at most 25% of the entire surface area in the rolled or folded state, and the rolled or folded layers adhere to one another in such a way that the laminar form of medication maintains its rolled or folded form for a period of at least one hour in the release test according to USP 23, Method A, apparatus 2, at 37° C. and 50 rpm, in artificial gastric juice, and at least 30% of the active substance contained in it is released in the rolled or folded state.
摘要翻译： 包含聚合物膜的卷曲或折叠层的时间释放层状药物组合物，其含有药物活性物质，其中含有活性物质的聚合物膜的外表面积并且可被消化液接触 相当于轧制或折叠状态下整个表面积的至多25％，并且卷起或折叠的层彼此粘合，使得层状形式的药物保持其卷曲或折叠形式一段时间 根据USP 23，方法A，装置2在37℃和50rpm，在人造胃液中的释放试验中至少1小时，其中含有的至少30％的活性物质被释放在轧制或 折叠状态。
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6.发明授权Aqueous dispersions containing carboxylic acids and/or resinic acids for deinking printed wastepaper 失效含有羧酸和/或树脂酸的水性分散体用于脱墨印刷废纸
公开(公告)号：US5725730A
公开(公告)日：1998-03-10
申请号：US328335
申请日：1994-10-24
申请人： Heinz-Gerd Smolka , Klaus Lehmann , Hans Hawel , Dieter Schraml , Klaus Hornfeck
发明人： Heinz-Gerd Smolka , Klaus Lehmann , Hans Hawel , Dieter Schraml , Klaus Hornfeck
IPC分类号： D21C5/02
CPC分类号： D21C5/027 , Y02W30/648
摘要： The invention relates to aqueous dispersions containing A. C.sub.6-22 carboxylic acids and/or resinic acids and B. C.sub.6-22 oxoalcohols alkoxylated with 2 to less than 6 mol C.sub.2-4 alkylene oxides for deinking printed wastepaper.
摘要翻译： 本发明涉及含有A.C6-22羧酸和/或树脂酸的水性分散体，以及用2到小于6mol的C2-4烯化氧烷氧基化的用于脱墨印刷废纸的B.C6-22多元醇。
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公开(公告)号：US5177451A
公开(公告)日：1993-01-05
申请号：US736727
申请日：1991-07-26
申请人： Klaus Lehmann
发明人： Klaus Lehmann
IPC分类号： H03F3/30
CPC分类号： H03F3/3076
摘要： A unity gain amplifier of the diamond follower type provides the combination of negligible input offset voltage, high slew rate, and high bandwidth by providing first and second opposite polarity current mirror circuits which respond to currents flowing through first and second input transistors to boost current available to charge parasitic capacitances during fast rise times and fast fall times of an input pulse. The rapid charging and discharging of the parasitic capacitances eliminates degradation in the rise and fall times of an output pulse produced by the unity gain amplifier. The gains of the first and second current mirror circuits have values that result in critically damped high frequency response of the unity gain amplifier in response to high speed transistions of the input signal. Darlington output stages are used to avoid frequency response peaking due to current gain rolloff of the output transistors at high currents and high frequencies. The unity gain amplifier is used in high performance operational transconductance amplifier.
摘要翻译： 金刚石跟随器类型的单位增益放大器通过提供响应于流过第一和第二输入晶体管的电流来提升可用电流的第一和第二相反极性电流镜电路，提供可忽略的输入失调电压，高转换速率和高带宽的组合 以在快速上升时间和输入脉冲的快速下降时间期间对寄生电容进行充电。 寄生电容的快速充电和放电消除了由单位增益放大器产生的输出脉冲的上升和下降时间的劣化。 第一和第二电流镜电路的增益具有响应于输入信号的高速转移导致单位增益放大器的严重衰减的高频响应的值。 达林顿输出级用于避免由于高电流和高频下输出晶体管的电流增益而导致的频率响应峰值。 单位增益放大器用于高性能运算跨导放大器。
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公开(公告)号：US5003269A
公开(公告)日：1991-03-26
申请号：US351406
申请日：1989-05-12
申请人： Klaus Lehmann
发明人： Klaus Lehmann
CPC分类号： H03F3/3076
摘要： A unity gain amplifier of the Diamond follower type provides the combination of negligible input offset voltage, high slew rate, and high bandwidth by providing first and second opposite polarity current mirror circuits which respond to currents flowing through first and second input transistors to boost current available to charge parasitic capacitances during fast rise times and fast fall times of an input pulse. The rapid charging and discharging of the parasitic capacitances eliminates degradation in the rise and fall times of an output pulse produced by the unity gain amplifier.
摘要翻译： 金刚石跟随器类型的单位增益放大器通过提供响应于流经第一和第二输入晶体管的电流来提升可用电流的第一和第二相反极性电流镜电路，提供可忽略的输入失调电压，高转换速率和高带宽的组合 以在快速上升时间和输入脉冲的快速下降时间期间对寄生电容进行充电。 寄生电容的快速充电和放电消除了由单位增益放大器产生的输出脉冲的上升和下降时间的劣化。
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9.发明授权
公开(公告)号：US4488052A
公开(公告)日：1984-12-11
申请号：US328475
申请日：1981-12-08
CPC分类号： H04N5/2173
摘要： To eliminate or suppress amplifier noise in amplifiers (6, 7) connected to a semiconductor light sensor, for example of a charge coupled type, in which the noise introduced by the amplifiers has a frequency spectrum which is low with respect to the clock frequency of operation of the sensor, the minimum value signal from the light sensor, as amplified, is determined; the maximum value of the signal, as amplified, is determined; and a reference is derived based on the minimum value, for example by clamping the minimum value, or utilizing the minimum value as a dynamic reference for subtraction from the maximum value, to thereby eliminate the effect of low-frequency shift of signals due to low-frequency noise of the amplifiers; various circuits may be used, such as clamping circuits (FIG. 3), threshold or non-additive mixing circuits (FIGS. 4, 5) coupled to a subtraction stage (24), band-pass filtering and envelope demodulation (FIG. 6: 28, 29, 30) or synchronous demodulation (FIG. 7: 34, 35) using the scanning clock frequency (36, 37) for synchronous demodulation, coupled with frequency limiting the output to, for example, one-half clock frequency in a low-pass filter (39).
摘要翻译： 为了消除或抑制连接到半导体光传感器（例如电荷耦合型）的放大器（6,7）中的放大器噪声，其中由放大器引入的噪声具有相对于时钟频率低的频谱 传感器的操作，确定来自光传感器的最小值信号，如放大; 确定放大的信号的最大值; 并且基于最小值导出参考，例如通过钳位最小值，或者利用最小值作为用于从最大值减去的动态参考，从而消除由于低的信号引起的低频偏移的影响 放大器的频率噪声; 可以使用各种电路，例如钳位电路（图3），耦合到减法级（24）的阈值或非加性混合电路（图4,5），带通滤波和包络解调（图6 ：28,29,30）或使用用于同步解调的扫描时钟频率（36,37）的同步解调（图7：34,35），并将输出频率限制为例如二分之一时钟频率 低通滤波器（39）。
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公开(公告)号：US4459552A
公开(公告)日：1984-07-10
申请号：US377601
申请日：1982-05-13
申请人： Michael Hausdorfer , Klaus Lehmann
发明人： Michael Hausdorfer , Klaus Lehmann
摘要： For reduction of the relative noise amplitude a modulator or chopper stage is provided in front of the input of a video preamplifier and at the preamplifier output balanced demodulators are provided with a subtraction circuit combining their outputs. Preferably the carrier wave used for chopping or modulation is applied to the demodulators for synchronous demodulation, with a phase shifter if necessary in the carrier supplied to the demodulators for compensation of the signal propogation time through the preamplifier.
摘要翻译： 为了降低相对噪声幅度，在视频前置放大器的输入端前面提供调制器或斩波级，并且在前置放大器输出平衡解调器上设置有组合其输出的减法电路。 优选地，用于斩波或调制的载波用于同步解调的解调器，如果需要，在提供给解调器的载波中使用移相器以补偿通过前置放大器的信号传播时间。
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