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公开(公告)号：US5342646A
公开(公告)日：1994-08-30
申请号：US979425
申请日：1992-11-19
CPC分类号： G01N33/545 , C07K17/08 , C12N11/08
摘要： What is disclosed is a method for preparing carrier systems, adaptable to the covalent bonding thereto of biologically active materials, consisting of a known solid support material having a surface coated with a polymer containing functional groups suitable for covalent bonding, by coating the support material with a film-forming polymer dispersion and a non-film-forming polymer dispersion, suitably in admixture, at least one of the two polymer dispersions containing a polymer having functional groups suitable for covalent bonding with a biologically active material.
摘要翻译： 公开的是一种制备载体系统的方法，其适用于生物活性材料的共价键合，其由已知的固体支持材料组成，所述固体支持材料具有涂覆有包含适于共价键合的官能团的聚合物的表面，通过用 一种成膜聚合物分散体和一种非成膜聚合物分散体，适当地混合两种聚合物分散体中的至少一种，其含有具有适于与生物活性材料共价键合的官能团的聚合物。
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2.发明授权
公开(公告)号：US4829101A
公开(公告)日：1989-05-09
申请号：US75416
申请日：1987-07-20
IPC分类号： C08F2/00 , A61K39/00 , C08F2/22 , C08F291/00 , C08J3/05 , C08L33/00 , C08L33/02 , C08L33/24 , C08L33/26 , C08L51/00 , C08L51/02 , C08L57/00 , C08L101/00 , C12N11/02 , G01N33/535 , G01N33/543 , G01N33/545 , G01N33/546 , G01N33/547
CPC分类号： G01N33/54313 , C08F291/00 , C12N11/02 , Y10S525/902
摘要： Polymer particles dispersible to form a latex and latices of such polymer particles, said particles being adaptable to the fixing or bonding thereto of a biologically active substance and having a core-shell construction wherein the polymer material of the core determines the stability of the form of the latex particles and their redispersibility, and the material of the shell(1) is so hydrophilic that it would be completely or largely water soluble if it were not anchored to the core material and/or crosslinked,(2) contains functional groups which are suitable for the covalent fixation or bonding of biological active substances, and(3) in an anhydrous condition has a T.sub..lambda.max from 20.degree.-250.degree. C., depending on its composition, and methods for bonding a biologically active substance to such particles, for example to prepare a diagnostic reagent.
摘要翻译： 可分散以形成胶乳的聚合物颗粒和这种聚合物颗粒的胶乳，所述颗粒适于固定或粘合生物活性物质并具有核 - 壳结构，其中芯的聚合物材料决定了 胶乳颗粒及其再分散性，并且壳（1）的材料是亲水性的，如果它不被锚定到芯材料和/或交联的话，它将完全或大部分是水溶性的，（2）包含官能团 适用于生物活性物质的共价固定或结合，（3）在无水状态下，根据其组成，T值为20〜250℃，以及将生物活性物质与该颗粒结合的方法 ，例如制备诊断试剂。
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3.发明授权High surface area support having bound latex particles containing oxirane groups for immobilization of substances 失效具有结合的胶体颗粒的高表面积载体含有用于固定物质的环氧乙烷基团
公开(公告)号：US5976527A
公开(公告)日：1999-11-02
申请号：US990554
申请日：1992-12-14
申请人： Werner Siol , Dieter Kraemer , Norbert Suetterlin , Cornelia Scordialo , Gerhard Markert , Erwin Schuster
发明人： Werner Siol , Dieter Kraemer , Norbert Suetterlin , Cornelia Scordialo , Gerhard Markert , Erwin Schuster
IPC分类号： C08F220/18 , A61K38/43 , B01J20/32 , C08F8/30 , C08J9/26 , C08J9/28 , C12N9/00 , C12N11/00 , C12N11/08 , C12Q1/00 , G01N33/543 , C12N11/14 , C07K17/14 , G01N33/551
CPC分类号： G01N33/543 , A61K38/465 , A61K38/47 , A61K38/4826 , B01J20/3204 , B01J20/3208 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08J9/26 , C08J9/28 , C12N11/00 , C12N11/08 , C12N9/00 , C12Q1/00 , G01N33/54353 , Y10S530/811 , Y10S530/815
摘要： A high surface area system is provided with latex particles for immobilization of substances containing nucleophilic groups. The high surface area system is formed by aggregating the latex particles or by bonding the latex particles to a porous support of high surface area. The latex particles contain groups such as oxirane groups that react with the nucleophilic groups. The substances containing nucleophilic groups may be enzymes or proteins such as albumin, immunoglobulins, blood-clotting factors, cell-membrane proteins or peptide hormones. The high surface area system may be used as a sorbent in removing pollutants, as a stationary phase in organic synthesis such as peptide synthesis, and in the therapeutic treatment of a patient.
摘要翻译： 高表面积系统提供了用于固定含有亲核基团的物质的胶乳颗粒。 通过聚集胶乳颗粒或通过将胶乳颗粒粘合到高表面积的多孔载体上而形成高表面积体系。 胶乳颗粒含有与亲核基团反应的基团如环氧乙烷基团。 含有亲核基团的物质可以是酶或蛋白质，例如白蛋白，免疫球蛋白，凝血因子，细胞膜蛋白或肽激素。 高表面积系统可用作吸附剂，用于除去有机合成如肽合成中的污染物，以及在患者的治疗中作为固定相。
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4.发明授权
公开(公告)号：US4710525A
公开(公告)日：1987-12-01
申请号：US930023
申请日：1986-11-07
IPC分类号： C08F2/00 , A61K39/00 , C08F2/22 , C08F291/00 , C08J3/05 , C08L33/00 , C08L33/02 , C08L33/24 , C08L33/26 , C08L51/00 , C08L51/02 , C08L57/00 , C08L101/00 , C12N11/02 , G01N33/535 , G01N33/543 , G01N33/545 , G01N33/546 , G01N33/547 , C08L83/00
CPC分类号： G01N33/54313 , C08F291/00 , C12N11/02 , Y10S525/902
摘要： Polymer particles dispersible to form a latex and latices of such polymer particles, said particles being adaptable to the fixing or bonding thereto of a biologically active substance and having a core-shell construction wherein the polymer material of the core determines the stability of the form of the latex particles and their redispersibility, and the material of the shell(1) is so hydrophilic that it would be completely or largely water soluble if it were not anchored to the core material and/or crosslinked,(2) contains functional groups which are suitable for the covalent fixation or bonding of biological active substances, and(3) in an anhydrous condition has a T.sub..lambda.max from 20.degree.-250.degree. C., depending on its composition, and methods for bonding a biologically active substance to such particles, for example to prepare a diagnostic reagent.
摘要翻译： 可分散以形成胶乳的聚合物颗粒和这种聚合物颗粒的胶乳，所述颗粒适于固定或粘合生物活性物质并具有核 - 壳结构，其中芯的聚合物材料决定了 胶乳颗粒及其再分散性，并且壳（1）的材料是亲水性的，如果它不被锚定到芯材料和/或交联的话，它将完全或大部分是水溶性的，（2）包含官能团 适用于生物活性物质的共价固定或结合，（3）在无水状态下，根据其组成，T值为20〜250℃，以及将生物活性物质与该颗粒结合的方法 ，例如制备诊断试剂。
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公开(公告)号：US4070348A
公开(公告)日：1978-01-24
申请号：US544830
申请日：1975-01-28
CPC分类号： C08F2/14 , C12N11/08 , Y10S435/897 , Y10S526/909 , Y10S526/91
摘要： Water-swellable, cross-linked, bead copolymers of (A) an ethylenically unsaturated monomer having a carboxylic acid anhydride, glycidyl or succinimide group, (B) a comonomer having at least two radical-polymerizable carbon double bonds, and (C) a radical-polymerizable water-soluble comonomer are disclosed to be excellent carriers capable of bonding with biologically active substances such as enzymes, enzyme substrates, inhibitors, hormones, antibiotics, antigens, and peptides.
摘要翻译： （A）具有羧酸酐的烯键式不饱和单体，缩水甘油基或琥珀酰亚胺基，（B）具有至少两个可自由基聚合的碳双键的共聚单体的水溶胀性，交联的珠粒共聚物，（C） 可自由基聚合的水溶性共聚单体被公开为能够与酶，酶底物，抑制剂，激素，抗生素，抗原和肽等生物活性物质结合的优异载体。
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公开(公告)号：US4388271A
公开(公告)日：1983-06-14
申请号：US300899
申请日：1981-09-10
申请人： Dieter Kraemer , Klaus Lehmann , Roland Hartl
发明人： Dieter Kraemer , Klaus Lehmann , Roland Hartl
CPC分类号： G01N33/725 , C12Q1/28 , Y10S436/904
摘要： The invention relates to diagnostic agents for the rapid diagnostic detection of blood in excretions and body fluids, consisting essentially of a solid support which is charged with a chromogenic substance as indicator and impregnated with an acrylic and/or methacrylic resin.
摘要翻译： 本发明涉及用于快速诊断检测排泄物和体液中的血液的诊断剂，其基本上由固体支持物组成，所述固体支持物装载有显色物质作为指示剂并用丙烯酸和/或甲基丙烯酸树脂浸渍。
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7.发明授权Method of bonding a polypeptide to a macromolecular polymeric carrier by irradiation with light 失效通过光照射将多肽与大分子聚合物载体结合的方法
公开(公告)号：US4039413A
公开(公告)日：1977-08-02
申请号：US426317
申请日：1973-12-19
申请人： Dieter Kraemer , Klaus Lehmann , Hermann Plainer
发明人： Dieter Kraemer , Klaus Lehmann , Hermann Plainer
IPC分类号： A61K39/44 , A61K41/00 , C07C67/00 , C07C231/00 , C07C231/12 , C07K17/08 , C12N11/08 , C12N11/12 , C12P21/04 , C08L1/00 , C08L3/00
CPC分类号： C12N11/08 , A61K39/44 , A61K41/0023
摘要： Methods for bonding a polypeptide to a macro-molecular carrier compound by irradiating an aqueous solution of the polypeptide, in the absence of oxygen and in the presence of said carrier compound, with ultraviolet light in the optional presence of a photosensitizer or with visible light in the presence of a photosensitizer and an organic peroxide.
摘要翻译： 将多肽与大分子载体化合物结合的方法，其中在无氧的情况下，在所述载体化合物的存在下，在任选的光敏剂存在下，或在可见光下，用紫外光照射多肽的水溶液 光敏剂和有机过氧化物的存在。
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8.发明授权Gathering configuration settings from a source system to apply to a target system 失效从源系统收集配置设置以应用于目标系统公开(公告)号：US07865707B2
公开(公告)日：2011-01-04
申请号：US11378096
申请日：2006-03-16
申请人： Sven Bittlingmayer , Oliver Goos , Dieter Kraemer , Martin Schwarz , Christopher Seiwert , Axel Westphal , Jens Wissenbach
发明人： Sven Bittlingmayer , Oliver Goos , Dieter Kraemer , Martin Schwarz , Christopher Seiwert , Axel Westphal , Jens Wissenbach
IPC分类号： G06F9/24
CPC分类号： G06F9/44505
摘要： Provided are a method, system and program for gathering configuration settings from a source system to apply to a target system. A source system is queried to determine configuration settings in the source system. A target system is queried to determine configuration settings in the target system. A user is enabled to enter configuration settings. The determined and user entered configuration settings are processed to generate commands to configure the target system to implement the configuration settings in the source system. The generated commands are executed to configure the target system.
摘要翻译： 提供了一种用于从源系统收集配置设置以应用于目标系统的方法，系统和程序。 查询源系统以确定源系统中的配置设置。 查询目标系统以确定目标系统中的配置设置。 启用用户进入配置设置。 处理确定的用户输入的配置设置以生成命令以配置目标系统来实现源系统中的配置设置。 执行生成的命令来配置目标系统。
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公开(公告)号：US4839419A
公开(公告)日：1989-06-13
申请号：US161204
申请日：1988-02-16
IPC分类号： A23C9/12 , B01F17/52 , C07K14/37 , C07K14/41 , C07K14/575 , C07K16/00 , C07K17/00 , C08H1/00 , C09H1/00 , C12N11/00 , C12P13/04 , C12P19/24
CPC分类号： A23C9/1206 , B01J20/3274 , B01J20/3282 , C12N11/00 , C12P13/04 , C12P19/24 , A23C2220/104
摘要： Methods for adsorbing a protein, for example an enzyme, onto an insoluble, solid, macroporous, small-particle support by washing said support with an aqueous solution of the protein containing an electrolyte in an ionic strength of at least 0.15 mole/liter and crosslinking said protein, before, during, or after such adsorption, with a coupling component present in aqueous electrolyte-containing solution.
摘要翻译： 通过用离子强度至少为0.15摩尔/升的含有电解质的蛋白质的水溶液洗涤所述载体，将蛋白质例如酶吸附到不溶性，固体，大孔的小颗粒载体上的方法和交联 所述蛋白质，在这种吸附之前，期间或之后，存在于含水电解质溶液中的偶联组分。
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公开(公告)号：USD297137S
公开(公告)日：1988-08-09
申请号：US890698
申请日：1986-07-28
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