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    MATERIALS AND METHODS FOR ASSAY OF ANTI-HEPATITIS C VIRUS (HCV) ANTIBODIES
    3.
    发明申请
    MATERIALS AND METHODS FOR ASSAY OF ANTI-HEPATITIS C VIRUS (HCV) ANTIBODIES 有权
    用于测定抗病毒C型病毒（HCV）抗体的材料和方法

    公开(公告)号：US20120202295A1

    公开(公告)日：2012-08-09

    申请号：US13168373

    申请日：2011-06-24

    申请人： Thomas P. Leary ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  George J. Dawson ,  Suresh M. Desai ,  Dinesh Shah

    发明人： Thomas P. Leary ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  George J. Dawson ,  Suresh M. Desai ,  Dinesh Shah

    IPC分类号： G01N33/576 ,  C12N1/21 ,  C12N15/70 ,  C07K14/18 ,  C12N15/51

    CPC分类号： G01N33/5767 ,  C07K14/005 ,  C12N2770/24222 ,  G01N2333/186 ,  G01N2469/20

    摘要： A polypeptide comprising the contiguous amino acids 1-198 of SEQ ID NO: 2; a polypeptide, which comprises a contiguous amino acid sequence that is at least about 95% identical to the contiguous amino acids 1-198 of SEQ ID NO: 2, an epitope that is immunoreactive with an antibody that specifically binds to the core protein of hepatitis C virus (HCV), and an epitope that is immunoreactive with an antibody that specifically binds to the NS4 region of HCV; a nucleic acid encoding such a polypeptide; a host cell comprising such a nucleic acid; an immunodiagnostic reagent comprising such a polypeptide; a kit comprising such an immunodiagnostic reagent; and a method of determining the presence, amount, or concentration of anti-HCV antibodies in a test sample.

    摘要翻译： 包含SEQ ID NO：2的连续氨基酸1-198的多肽; 一种多肽，其包含与SEQ ID NO：2的连续氨基酸1-198至少约95％相同的连续氨基酸序列，与特异性结合肝炎核心蛋白的抗体具有免疫反应性的表位 C病毒（HCV）和与特异性结合HCV的NS4区域的抗体免疫反应的表位; 编码这种多肽的核酸; 包含这种核酸的宿主细胞; 包含这种多肽的免疫诊断试剂; 包含这种免疫诊断试剂的试剂盒; 以及确定测试样品中抗HCV抗体的存在，量或浓度的方法。

    Materials and methods for assay of anti-hepatitis C virus (HCV) antibodies
    4.
    发明授权
    Materials and methods for assay of anti-hepatitis C virus (HCV) antibodies 有权
    用于测定抗丙型肝炎病毒（HCV）抗体的材料和方法

    公开(公告)号：US09551714B2

    公开(公告)日：2017-01-24

    申请号：US13168373

    申请日：2011-06-24

    申请人： Thomas P. Leary ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  George J. Dawson ,  Suresh M. Desai ,  Dinesh Shah

    发明人： Thomas P. Leary ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  George J. Dawson ,  Suresh M. Desai ,  Dinesh Shah

    IPC分类号： C07K14/005 ,  G01N33/576

    CPC分类号： G01N33/5767 ,  C07K14/005 ,  C12N2770/24222 ,  G01N2333/186 ,  G01N2469/20

    摘要： A polypeptide comprising the contiguous amino acids 1-198 of SEQ ID NO: 2; a polypeptide, which comprises a contiguous amino acid sequence that is at least about 95% identical to the contiguous amino acids 1-198 of SEQ ID NO: 2, an epitope that is immunoreactive with an antibody that specifically binds to the core protein of hepatitis C virus (HCV), and an epitope that is immunoreactive with an antibody that specifically binds to the NS4 region of HCV; a nucleic acid encoding such a polypeptide; a host cell comprising such a nucleic acid; an immunodiagnostic reagent comprising such a polypeptide; a kit comprising such an immunodiagnostic reagent; and a method of determining the presence, amount, or concentration of anti-HCV antibodies in a test sample.

    摘要翻译： 包含SEQ ID NO：2的连续氨基酸1-198的多肽; 一种多肽，其包含与SEQ ID NO：2的连续氨基酸1-198至少约95％相同的连续氨基酸序列，与特异性结合肝炎核心蛋白的抗体具有免疫反应性的表位 C病毒（HCV）和与特异性结合HCV的NS4区域的抗体免疫反应的表位; 编码这种多肽的核酸; 包含这种核酸的宿主细胞; 包含这种多肽的免疫诊断试剂; 包含这种免疫诊断试剂的试剂盒; 以及确定测试样品中抗HCV抗体的存在，量或浓度的方法。

    INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME
    5.
    发明申请
    INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME 审中-公开
    不同标记的测定结合物及其制备方法和使用方法

    公开(公告)号：US20090068635A1

    公开(公告)日：2009-03-12

    申请号：US11851050

    申请日：2007-09-06

    申请人： Anthony S. Muerhoff ,  Suresh M. Desai ,  Thomas P. Leary ,  George J. Dawson ,  Robin A. Gutierrez

    发明人： Anthony S. Muerhoff ,  Suresh M. Desai ,  Thomas P. Leary ,  George J. Dawson ,  Robin A. Gutierrez

    IPC分类号： C12Q1/70 ,  C07K1/107 ,  C07K14/765 ,  G01N33/53

    CPC分类号： G01N33/56983 ,  C07K1/13 ,  G01N33/532 ,  G01N2333/186

    摘要： Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided.

    摘要翻译： 间接标记的测定缀合物，其通过包括将缀合物包含的结合成员在标记结合成员之前提交至变性条件的方法制备。 间接标记的测定缀合物在用于诊断测定中的灵敏度增加，与通过不包括在标记之前将结合成员提交至变性条件的步骤的方法制备的测定缀合物相比较。 还提供了用于制备间接标记的测定缀合物的方法，检测包括使用间接标记的测定缀合物的分析物的方法和包含间接标记的缀合物的试剂盒。

    INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME
    6.
    发明申请
    INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME 审中-公开
    不同标记的测定结合物及其制备方法和使用方法

    公开(公告)号：US20120329176A1

    公开(公告)日：2012-12-27

    申请号：US13600979

    申请日：2012-08-31

    申请人： Anthony S. Muerhoff ,  Suresh M. Desai ,  Thomas P. Leary ,  George J. Dawson ,  Robin A. Gutierrez

    发明人： Anthony S. Muerhoff ,  Suresh M. Desai ,  Thomas P. Leary ,  George J. Dawson ,  Robin A. Gutierrez

    IPC分类号： C07K1/13 ,  G01N21/76 ,  C07K19/00

    CPC分类号： G01N33/56983 ,  C07K1/13 ,  G01N33/532 ,  G01N2333/186

    摘要： Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided.

    摘要翻译： 间接标记的测定缀合物，其通过包括将缀合物包含的结合成员在标记结合成员之前提交至变性条件的方法制备。 间接标记的测定缀合物在用于诊断测定中的灵敏度增加，与通过不包括在标记之前将结合成员提交至变性条件的步骤的方法制备的测定缀合物相比较。 还提供了用于制备间接标记的测定缀合物的方法，检测包括使用间接标记的测定缀合物的分析物的方法和包含间接标记的缀合物的试剂盒。

    INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME
    7.
    发明申请
    INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME 审中-公开
    不同标记的测定结合物及其制备方法和使用方法

    公开(公告)号：US20100279432A1

    公开(公告)日：2010-11-04

    申请号：US12832262

    申请日：2010-07-08

    申请人： Anthony S. Muerhoff ,  Suresh M. Desai ,  Thomas P. Leary ,  George J. Dawson ,  Robin A. Gutierrez

    发明人： Anthony S. Muerhoff ,  Suresh M. Desai ,  Thomas P. Leary ,  George J. Dawson ,  Robin A. Gutierrez

    IPC分类号： G01N33/53 ,  C07K1/13 ,  C07K14/765 ,  C07K14/435 ,  C07K14/77

    CPC分类号： G01N33/56983 ,  C07K1/13 ,  G01N33/532 ,  G01N2333/186

    摘要： Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided.

    摘要翻译： 间接标记的测定缀合物，其通过包括将缀合物包含的结合成员在标记结合成员之前提交至变性条件的方法制备。 间接标记的测定缀合物在用于诊断测定中的灵敏度增加，与通过不包括在标记之前将结合成员提交至变性条件的步骤的方法制备的测定缀合物相比较。 还提供了用于制备间接标记的测定缀合物的方法，检测包括使用间接标记的测定缀合物的分析物的方法和包含间接标记的缀合物的试剂盒。