公开(公告)号：US07358074B2

公开(公告)日：2008-04-15

申请号：US11143984

申请日：2005-06-02

申请人： Donald G. Jackson ,  Chandra S. Ramanathan ,  Liana Lee ,  Nathan Siemers ,  Suzanne J. Suchard ,  Joshua Finger ,  C. Gordon Todderud ,  Dana Banas

发明人： Donald G. Jackson ,  Chandra S. Ramanathan ,  Liana Lee ,  Nathan Siemers ,  Suzanne J. Suchard ,  Joshua Finger ,  C. Gordon Todderud ,  Dana Banas

IPC分类号： C12N9/16 ,  C12N1/20 ,  C12N15/63 ,  C12P21/00 ,  C12P21/04 ,  C12P21/06 ,  C07H21/04

CPC分类号： G06F19/16 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/03048 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/916 ,  G01N2500/00 ,  G01N2500/04 ,  Y02A90/26

摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07153678B2

公开(公告)日：2006-12-26

申请号：US10029345

申请日：2001-12-20

申请人： Donald G. Jackson ,  Chandra S. Ramanathan ,  John N. Feder ,  Liana Lee ,  Thomas C. Nelson ,  Nathan Siemers ,  Suzanne J. Suchard ,  Joshua Finger ,  C. Gordon Todderud ,  Dana Banas

发明人： Donald G. Jackson ,  Chandra S. Ramanathan ,  John N. Feder ,  Liana Lee ,  Thomas C. Nelson ,  Nathan Siemers ,  Suzanne J. Suchard ,  Joshua Finger ,  C. Gordon Todderud ,  Dana Banas

IPC分类号： C12N9/18 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： G06F19/16 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/03048 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/916 ,  G01N2500/00 ,  G01N2500/04 ,  Y02A90/26

摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07198911B2

公开(公告)日：2007-04-03

申请号：US10077111

申请日：2002-02-15

申请人： C. Gordon Todderud ,  Joshua Finger ,  Jill Rillema

发明人： C. Gordon Todderud ,  Joshua Finger ,  Jill Rillema

IPC分类号： C12P12/06 ,  C12Q1/68 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/47

摘要： The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

摘要翻译： 本发明描述了一种新发现的多核苷酸，其编码参与由TNF-α刺激的人微血管内皮细胞以及小鼠和大鼠RET16直系同源物克隆，分离和鉴定的细胞信号级联的称为RET16的蛋白质。 还描述了与本发明的多核苷酸和/或多肽相关的RET16多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 描述了用于筛选人RET16蛋白的调节剂，特别是抑制剂的方法，以及RET16多核苷酸和多肽用于治疗和诊断的用途。